DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-C and ada2a

DIOPT Version :9

Sequence 1:	NP_650308.3	Gene:	Adgf-C / 41680	FlyBaseID:	FBgn0038173	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001028889.2	Gene:	ada2a / 373884	ZFINID:	ZDB-GENE-030902-4	Length:	503	Species:	Danio rerio

Alignment Length:	478	Identity:	182/478 - (38%)
Similarity:	253/478 - (52%)	Gaps:	19/478 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RQAVLTAEEELMTGGHTHLNTEEEKVDDIFMEYKLGELAQGFRNAEQNAAALHFFKAKPLIDRSA 93
            |.|::..|....|||...||..|:.:|.     ||.:|.|....|.|...::||||||.|||:|.
Zfish    31 RDALIGLEASRRTGGDITLNEREKLLDG-----KLQKLKQHDMEAGQFPPSMHFFKAKRLIDQSP 90

  Fly    94 IFRFLQKMPKGSVLHVHNTASVSSKWVVDDLSYMPGLLRCTT--ATGQSILSFRRTPKEHKCQSQ 156
            :|..:||||||:.||||:.|.||..|:|.:::|......|.|  .|.|.|.|.........| |.
Zfish    91 VFNLIQKMPKGAALHVHDFAMVSVDWLVKNVTYRENCYVCFTDKQTVQFIFSSGPPASSSHC-SS 154

  Fly   157 YVLVSDERRNSLDRQVYDRNFERLINLYTPVPELEYPTITRVWDRFQGMFDGLSDALIYLPAFRA 221
            :.|:...|....:....|.:|.|.:.|:|..|:..||....||:||:.:|......:.|.|.|:.
Zfish   155 WTLLRSLREKIKNTTELDNSFIRNLTLFTEDPDRAYPNQDTVWERFEQVFLVAYGLVTYAPVFKD 219

  Fly   222 YHWQMLEELYNDNVMYTEIRTSFKTLYDASGRTFPRERTIHELYALNQKFMKLHPDFLGFKVIMA 286
            |.::.|.:.|.||:||.|||......|:..||...::.::.....:..:|.|.||||:|.:||..
Zfish   220 YLYEGLRQFYEDNIMYVEIRALLPQTYELDGRLNDKDWSMAACQEVVNQFKKHHPDFIGARVIFT 284

  Fly   287 VYRGYELDHLKDIVEVFKKLHQALPHFLVGFDLVGQEDKGKPLYSLLPVLR-------DLPPTAR 344
            |:|..........||....|.:..|..:.|||.|||||.|:||:.....|.       :||
Zfish   285 VHRKINATEAVKTVEEAMILRRNFPDVMAGFDFVGQEDLGRPLWYFKDALSLPEDKGFNLP---- 345

  Fly   345 LFLHGGETNWFGASTDINLLDALLMNTTRIGHGYALAKHPILLNAVKSRRIAVELSPISNQVLHL 409
            .|.|.|||:..|...|.||:||||.||||||||:|||:||::....:...:.:|:.|||||||.|
Zfish   346 YFFHAGETDSQGTDVDQNLMDALLFNTTRIGHGFALARHPVVKEMARKMYVPIEVCPISNQVLKL 410

  Fly   410 VWDLRNHPGSQFFALDVPVVICNDDPGFWNAKGLSYDFYYAIMSLAPNNAGLRLLKTLVWNSVRY 474
            |.|||:||.:...|...|:||.:|||..:.|..||:|||.|.|.....:..|..||.|..||:||
Zfish   411 VSDLRDHPAAVLMAEGHPLVISSDDPAVFGATALSHDFYEAFMGFGGMSFNLGTLKELALNSLRY 475

  Fly   475 STLTEEEQTRAFKILELSWSRFI 497
            |||:.:.:..|...|.:.|.:|:
Zfish   476 STLSSQRKEEAIDALLVKWDKFV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-C	NP_650308.3	A_deaminase_N	5..98	CDD:285627	27/68 (40%)
		adm_rel	25..501	CDD:273620	182/478 (38%)
		ADGF	78..493	CDD:238646	164/423 (39%)
ada2a	NP_001028889.2	A_deaminase_N	<29..95	CDD:285627	27/68 (40%)
		adm_rel	30..502	CDD:273620	182/478 (38%)
		ADGF	75..494	CDD:238646	164/423 (39%)
		Substrate binding. /evidence=ECO:0000250	197..204		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595073
Domainoid	1	1.000	49	1.000	Domainoid score	I11796
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81852
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.720