Protein Alignment Adgf-C and AMPD1

DIOPT Version :10

• Sequence 1: NP_650308.3
• Gene: Adgf-C / 41680
• FlyBaseID: FBgn0038173
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000027.3
• Gene: AMPD1 / 270
• HGNCID: 468
• Length: 747
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 118/565 - (20%)
• Similarity: 193/565 - (34%)
• Gaps: 198/565 - (35%)

  Fly     7 FVVLLTAQLQIQAQTALSYEQARQAVLTAEEELMTGGHTHLNTEEEKVDDIFMEYKLGELA---- 67
            |::.|.||..::     :|...|...|:::.::    |..||..:|          |.||.
Human   246 FLLALIAQGPVK-----TYTHRRLKFLSSKFQV----HQMLNEMDE----------LKELKNNPH 291

  Fly    68 QGFRNAEQNAAALHFFKAKPLIDRSAIFRFLQKMPKGSVLHVHNTASVSSKWVVDDLSYMPGLLR 132
            :.|.|..:....:|   |...:::..:.||::|                        ||.....|
Human   292 RDFYNCRKVDTHIH---AAACMNQKHLLRFIKK------------------------SYQIDADR 329

  Fly   133 CTTATGQSILSFRRTPKEHKCQSQYVLVSDERRNSLD----RQVYDRNFERLINLYTPVPELEYP 193
            ...:|.:..|:.:....:.| ...|.|..|    |||    ||.:.| |::..:.|.||
Human   330 VVYSTKEKNLTLKELFAKLK-MHPYDLTVD----SLDVHAGRQTFQR-FDKFNDKYNPV------ 382

  Fly   194 TITRVWDRFQGMFDGLSDALIYLPAFRAYHWQMLEELY--NDNVMYTEIRTSFKTLYDASGRTFP 256
                          |.|:               |.:||  .||.:..|.   |.|:....|....
Human   383 --------------GASE---------------LRDLYLKTDNYINGEY---FATIIKEVGADLV 415

  Fly   257 RERTIH-----ELYALN-QKFMKLHPDFLGFKV-------IMAVYRGYELDHLKDIVEVFKKL-- 306
            ..:..|     .:|..: .::.||...|:..::       ::.|.|.|::...|:.:..|.|:
Human   416 EAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE 480

  Fly   307 ------------HQALPHF------LVGFDLVGQEDK----------GKP--------------- 328
                        .||.|..      :.|||.|..|.|          .||
Human   481 NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYA 545

  Fly   329 --LYSLLPVLRDLPPTARL--FL---HGGETNWFGASTDINLLDALLMNTTRIGHGYALAKHPIL 386
              :|:.:.||..|.....:  ||   |.||.   ||.|  :|:.|.:: ...|.||..|.|.|:|
Human   546 YYMYANIMVLNSLRKERGMNTFLFRPHCGEA---GALT--HLMTAFMI-ADDISHGLNLKKSPVL 604

  Fly   387 LNAVKSRRIAVELSPISNQVLHLVWDLRNHPGSQFFALDVPVVICNDDPGFWNAKGLSYDF---- 447
            .......:|.:.:||:||..|.|  :...:|...|....:.:.:..|||       :.:.|
Human   605 QYLFFLAQIPIAMSPLSNNSLFL--EYAKNPFLDFLQKGLMISLSTDDP-------MQFHFTKEP 660

  Fly   448 ---YYAIMSLAPNNAGLRLLKT-----LVWNSVRYSTLTEEEQTR 484
               .|||.      |.:..|.|     :..|||....::.||:.:
Human   661 LMEEYAIA------AQVFKLSTCDMCEVARNSVLQCGISHEEKVK 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-C	NP_650308.3	A_deaminase_N	4..98	CDD:462481	19/94 (20%)
		ADGF	78..493	CDD:238646	102/490 (21%)
AMPD1	NP_000027.3	AMP_deaminase	113..745	CDD:437158	118/565 (21%)