DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment omd and Ints5

DIOPT Version :9

Sequence 1:	NP_001262542.1	Gene:	omd / 41674	FlyBaseID:	FBgn0038168	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001101046.1	Gene:	Ints5 / 309200	RGDID:	1309370	Length:	1019	Species:	Rattus norvegicus

Alignment Length:	1125	Identity:	262/1125 - (23%)
Similarity:	410/1125 - (36%)	Gaps:	279/1125 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QNLLDQLKHFIETVSN--GHSCPQLLTSPNLIKLALGFLEELPATRDIVFEYFALLAEISVQLYV 66
            |.|..::|.|:.....  ||.    |::....:.:|..|..||..|..|.::...:.:.||:.::
  Rat    29 QELSQEIKAFLTGADPILGHQ----LSAREHARCSLLLLRSLPPARAAVLDHLRGVFDESVRAHL 89

  Fly    67 -----SPEMADPKTGMPVSQVKLAGNRQQQQRAPEYEAFNLVKTALQSLVWKGPPAWSPLIANWS 126
                 ||....|....|.|....||....:....|      |:..|...:...|.||:|:|:.||
  Rat    90 AALEESPVAGPPHLRPPPSSHVPAGGPGLEDVVHE------VQQVLCEFIRANPKAWAPVISAWS 148

  Fly   127 LELVAKLSDKYT---QRRMTITASCN----YWLECSAMHGLMTLINSCFRKLTQPEEEACVEIML 184
            ::|:.:||..|:   ||....|.|.|    .|:.|.|...||.:...|...|.....:|||:.:|
  Rat   149 IDLMGQLSSTYSGQHQRVPHATGSLNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALL 213

  Fly   185 NAFHRFPMTFDWIVARLGGCFPYKIIMQILQCGIKRFVDDYRCH--------------------- 228
            :...:....|||:||.:|..||..||.::|.||:|    |:..|
  Rat   214 DTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLK----DFCVHSGAGGGASACGGSSSQTPSSD 274

  Fly   229 ----------------LDSEAGILDYMTSCHEQHLRAAFREMLR---------EGFAPKKPLDVA 268
                            :.|..|||.::.|.|...:|   ||:||         .|....:|...|
  Rat   275 PFPGSPAIPGEKRVPKIASVVGILGHLASRHGDSIR---RELLRMFHDSLSGGTGGRNGEPSLQA 336

  Fly   269 VVPFLLITTNYSDTILQSLVNVLVEIYTEDMCEVIVQKAPLWLS--NKMFAG-----MQPTLNNA 326
            .|||||.....|..:|.::...||:..          |.|..||  .:...|     :...||.|
  Rat   337 TVPFLLQLAVMSPALLGTVSGELVDCL----------KPPAVLSQLQQHLQGFPREELDNMLNLA 391

  Fly   327 VLRLNERGAT-------LLLTAAKMAEKYVW------------CQDFLDNSMQELEQWVLNQ--- 369
            |..:::...|       .|:..|..|.....            |...:...:..|::.|.::
  Rat   392 VHLVSQASGTGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGS 456

  Fly   370 ------------RNFPLL-------ADLAYE----ETKYMLWKSCLSTNLFEQQTAVRLLLVVSS 411
                        |..|.|       .:|..|    |.|..||          |...:.||.|.:
  Rat   457 PGEGVLGPPPPPRPVPFLDALRNHVGELCGETLRLERKRFLW----------QHQLLGLLSVYT- 510

  Fly   412 QHPNIYYQTISQLLKKSYAQNPNGIGALIRLLGGQSGMVNFPGFTPGFKMVLEDITLDVQVNNRL 476
             .|:...:.:..||  |.|::|..:....:|..|                      |.|.::..|
  Rat   511 -RPSCGPEALGHLL--SRARSPEELSLATQLYAG----------------------LVVSLSGLL 550

  Fly   477 PVPPGTPTEAFNTFSNLNILARMHKSKNVAPYIKAQHLNQALNECLPKILQIFDCTVNKLVLRID 541
            |:       ||.     :.|||:|......|:......|.|                  |::..:
  Rat   551 PL-------AFR-----SCLARVHAGTLQPPFTARLLRNLA------------------LLVGWE 585

  Fly   542 RDAAE---RIADKFRAQQSKNSNNNNELCNGKDYGKRTKLEPGEDKVDDEDATRMRLAHLIVDLL 603
            :...|   .:..:|....|.:.::...|.          |.| |::|.:..|:.:.:.....:.|
  Rat   586 QQGGEGPSTLGARFGESASAHLSDLAPLL----------LHP-EEEVAEAAASLLAICPFPSEAL 639

  Fly   604 NNIEAGSRTTVLRTPLVLKLATLSVKYFFVGLTEKTVIRRAAASHRSYTLLQRQCSARKIARTVC 668
            :..:            :|.|....|..||..|........|:||.    ||.|............
  Rat   640 SPSQ------------LLGLVRAGVHRFFASLRLHGPPGVASASQ----LLTRLSQTSPAGLKAV 688

  Fly   669 LRELVERAL------FYHGHLLGQLEVYQLDELEIPEHEHLILQNLHTSS--GANSNRSVLHSGI 725
            |:.|||.||      .:.|.:.|..|...:....:.....|.:...||::  |.....||.|:|:
  Rat   689 LQLLVEGALHRGNTELFGGEMDGDNETLSIVSTPLASASLLDINRRHTAAVPGPGGIWSVFHAGV 753

  Fly   726 IGRGLRPVLPPSERNCDAEKQALY-----LKALNACCADLEKPNNVEG-----------YSLVSL 774
            |||||:|......||   .::.:|     :..|..||: ....|..||           ...|::
  Rat   754 IGRGLKPPKIVQSRN---HQEVIYNTQSLVNLLVHCCS-ASGSNEREGCWGAPTLSPEAAKAVAV 814

  Fly   775 LLVELVSTDVMYNGLPFPDEEFTRVTMERDMLIRRAFINSPVLWAVLGLIAGHRPALCYSSVLLR 839
            .|||.|..|.....|.:|.|:..|.|:|||:.|.|.|...|:|:.:|.|:|...|||||.|||||
  Rat   815 TLVESVCPDAAGAELAWPPEDHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLR 879

  Fly   840 ALCATCLHHWRGKNVNRFQPTAANDELMLCTKKMLQLLAMSQLIPPPLTNLHLIIEHFESAEIAL 904
            .|.|..|.||   ..:|...|..:...:..:..::.::|...|:||.|.|:|.:.......|:.|
  Rat   880 GLLAALLSHW---EASRHPDTTHSPWHLEASCILVAVMAEGSLLPPALGNMHEVFSQLAPFEVRL 941

  Fly   905 LLRECIWNYLKDHVPSPALF-HVDNNGLHWRNTNTQLAKVPPQYVDPLRHLMQRKLSTLGPHYHQ 968
            ||.. :|.:|::|.|.|..| .....|...|:.:.:.......::..|..::.|.:..||
  Rat   942 LLLS-VWGFLREHGPLPQKFIFQSERGRFIRDFSREGGGEGGPHLSVLHSVLHRNIDRLG----- 1000

  Fly   969 MFIMGELMEGDSEPDPTARL 988
                  |..|..:..|.:.|
  Rat  1001 ------LFSGRFQAPPPSTL 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
omd	NP_001262542.1	INTS5_N	4..221	CDD:291503	66/230 (29%)
omd	NP_001262542.1	INTS5_C	229..962	CDD:291504	188/821 (23%)
Ints5	NP_001101046.1	INTS5_N	29..251	CDD:291503	67/235 (29%)
Ints5	NP_001101046.1	INTS5_C	290..999	CDD:291504	188/822 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348830
Domainoid	1	1.000	87	1.000	Domainoid score	I7870
eggNOG	1	0.900	-	-		E1_28HHP
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3661
OMA	1	1.010	-	-		QHG46681
OrthoDB	1	1.010	-	-		D108880at2759
OrthoFinder	1	1.000	-	-		FOG0009533
OrthoInspector	1	1.000	-	-		oto96367
orthoMCL	1	0.900	-	-		OOG6_108361
Panther	1	1.100	-	-	LDO	PTHR31697
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770