DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9588 and htra1b

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_001104652.1	Gene:	htra1b / 565082	ZFINID:	ZDB-GENE-080219-7	Length:	476	Species:	Danio rerio

Alignment Length:	180	Identity:	38/180 - (21%)
Similarity:	67/180 - (37%)	Gaps:	44/180 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NVGMS-GPLVDAEGFPRNDIDVYQVRLARQTIICLQNDHKELMNQIQTLLNQYHSEIA------- 93
            |.|.| ||||:.:|   ..|.:..:::.......:.:|      :|:..|.:.|...|
Zfish   320 NYGNSGGPLVNLDG---EVIGINTLKVTAGISFAIPSD------KIRQFLAESHDRQAKGKTATK 375

  Fly    94 ---------TTDPELVNRASALDLDSDRSPGGANITDLAPARAIVVVNLVSPDSPAERAGLCAGD 149
                     |..|.|.........|......||.:.:            |.|.:|||..||...|
Zfish   376 KKYIGVRMMTLTPTLAKELKQRKNDFPDVTSGAYVIE------------VIPKTPAEVGGLKESD 428

  Fly   150 AILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLILVPK 199
            .|:   ||| |......:.:...::.  .::::..|:||.:.:.|.::|:
Zfish   429 VII---SIN-GQRITSASDVSTAIKT--DESLRAVVRRGNEDIILTIIPE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	15/69 (22%)
htra1b	NP_001104652.1	IGFBP	29..85	CDD:278641
		KAZAL_FS	109..151	CDD:238052
		DegQ	155..476	CDD:223343	38/180 (21%)
		Serine protease. /evidence=ECO:0000250	200..360		11/48 (23%)
		Trypsin_2	200..338	CDD:290102	9/20 (45%)
		PDZ_serine_protease	378..469	CDD:238487	23/108 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900