DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and nmur1a

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_021325138.1	Gene:	nmur1a / 557276	ZFINID:	ZDB-GENE-081104-220	Length:	428	Species:	Danio rerio

Alignment Length:	435	Identity:	144/435 - (33%)
Similarity:	212/435 - (48%)	Gaps:	105/435 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PSPNQSPSIGVGIGIASSTMANPSESPEML--LLKNDKFLTHVAHLLNIT-----------TENL 79
            |.||           .|||   .|.:|:.:  ||.|    |.||  ||:|           .|.|
Zfish     3 PKPN-----------CSST---DSSTPKCIQDLLCN----TSVA--LNLTEMEIEDFCLDQDEYL 47

  Fly    80 SNLLGSTNGTNASTMAADSPVDESLTLRTALTVC--YALIFVAGVLGNLITCIVISRNNFMHTAT 142
            ...||...          |||        .|.||  |.|||:.|.:||::|||||::|..|.|.|
Zfish    48 EKYLGPRR----------SPV--------FLPVCLTYLLIFLVGAVGNILTCIVIAKNKVMRTPT 94

  Fly   143 NFYLFNLAVSDLILLVSGIPQELYNLWYPDMYPFT--DAMCIMGSVLSEMAANATVLTITAFTVE 205
            |||||:||:|||::|:.|:|.|||.:|  ..|||.  ...|...::|.|....|::|.:||.:||
Zfish    95 NFYLFSLAISDLLVLLLGMPLELYEMW--SNYPFLLGKGGCYFKTLLFETVCFASILNVTALSVE 157

  Fly   206 RYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVV-----------YQNEGYSCT 259
            ||||:.||.|...:...:.|.:.|.::|..:.|.|:|..:...:.           ...:..:|.
Zfish   158 RYIAVIHPLRAKYVVTRTHAKRLILSVWSISVLCAIPNTILHGIFTLPPPKGKAAGVMLDSATCM 222

  Fly   260 MEND--FYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPRRTFDANRGLNAQG--- 319
            :...  .|..:..::..:||..||..|.|||:|||::|||.::||.|..:   |:.||::..
Zfish   223 LVKPRWMYNLIIQITTLLFFLLPMLTISVLYLLIGMQLKREKMLQVLEAK---ASSGLDSSSNVR 284

  Fly   320 ---------RVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFN-DYFRILDYT-- 372
                     :|.:||..:.|.|.:||||||..|||       .:....:|:.: :.|.:.:|.
Zfish   285 SQQQKTRRQQVTKMLFVLVVMFGICWAPFHTDRLM-------WSFMDQKDSEHIEIFEVYEYVHV 342

  Fly   373 -SGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQ 416
             |||.::||:.|||:|||:||.:|||.||..:.         ||:
Zfish   343 ISGVFFYLSSAINPVLYNLMSTRFREMFKEVMC---------HHK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	57/129 (44%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	100/294 (34%)
nmur1a	XP_021325138.1	7tmA_NMU-R1	60..370	CDD:320480	116/321 (36%)
		TM helix 1	60..87	CDD:320480	15/26 (58%)
		TM helix 2	94..120	CDD:320480	17/25 (68%)
		TM helix 3	133..163	CDD:320480	13/29 (45%)
		TM helix 4	175..197	CDD:320480	6/21 (29%)
		TM helix 5	230..259	CDD:320480	12/28 (43%)
		TM helix 6	290..320	CDD:320480	14/36 (39%)
		TM helix 7	338..363	CDD:320480	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578487
Domainoid	1	1.000	184	1.000	Domainoid score	I3341
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6488
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.880