DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and OR7G2

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001005193.2	Gene:	OR7G2 / 390882	HGNCID:	8466	Length:	324	Species:	Homo sapiens

Alignment Length:	331	Identity:	69/331 - (20%)
Similarity:	123/331 - (37%)	Gaps:	67/331 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 ESLTLRTALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELY 166
            |...|:..|...:..:::..:||||:..:.:..::.:||...|:|.||:..|:.|..:.||:.|.
Human    19 EDPELQPVLFSLFLSMYLVTILGNLLILLAVISDSHLHTPMYFFLSNLSFLDICLSTTTIPKMLV 83

  Fly   167 NLWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHT------------- 218
            |:...:. ..|.:.|:.........|......:.|...:||:|||||.|...
Human    84 NIQAQNR-SITYSGCLTQICFVLFFAGLENCLLAAMAYDRYVAICHPLRYTVIMNPRLCGLLILL 147

  Fly   219 -----------MSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNEGYSCTMENDFYAHVFAVS 272
                       :|.:...:.|...:.:..|...|.|.:|.:.       |.|:.|:...:..|.
Human   148 SLLTSVVNALLLSLMVLRLSFCTDLEIPLFFCELAQVIQLTC-------SDTLINNILIYFAAC- 204

  Fly   273 GFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPRRTFDANRGLNAQGRVIRMLVAVAVAFFLCWA 337
              ||.|.|::.|.:.|..|      :..:..:|          :|.|:        ..|...|.:
Human   205 --IFGGVPLSGIILSYTQI------TSCVLRMP----------SASGK--------HKAVSTCGS 243

  Fly   338 PFHAQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKIT 402
              |...::..||..| .:.|| ....|..|.....|.:.......:||.:|::.:    :..|.|
Human   244 --HLSIVLLFYGAGL-GVYIS-SVVTDSPRKTAVASVMYSVFPQMVNPFIYSLRN----KDMKGT 300

  Fly   403 LTRQFG 408
            |.:..|
Human   301 LRKFIG 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	31/151 (21%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	60/287 (21%)
OR7G2	NP_001005193.2	7tmA_OR7-like	25..301	CDD:320362	64/318 (20%)
		TM helix 1	27..51	CDD:320362	5/23 (22%)
		TM helix 2	60..82	CDD:320362	8/21 (38%)
		TM helix 3	98..120	CDD:320362	2/21 (10%)
		TM helix 4	143..159	CDD:320362	0/15 (0%)
		TM helix 5	196..219	CDD:320362	6/25 (24%)
		TM helix 6	238..260	CDD:320362	5/24 (21%)
		TM helix 7	269..294	CDD:320362	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7811
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950