DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK2-R1 and CCHa2-R

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	132/518 - (25%)
Similarity:	217/518 - (41%)	Gaps:	115/518 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 GTNASTMAADSP----VDESLTLRTALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFN 148
            |.|||......|    :|...|.  .:||.|.|||:.|||||....|:..|:..|....|.|:.:
  Fly    48 GHNASADGGIVPYVPVLDRPETY--IVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILS 110

  Fly   149 LAVSDLILLVSGIPQELYNLWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHP 213
            ||::||::::..:|.... ::..:.:||...||.:.....:::...:|.|:||.:.|||.||.:|
  Fly   111 LALADLLVILVCVPVATI-VYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNP 174

  Fly   214 FRQHTMSKLSRAIKFIFA---IWLAAFLLALPQAMQFSVVYQNEGYSCT----------MENDFY 265
            .|     ||......:|.   ||:.|.||.:|..: ||.:.....::.|          ..:..|
  Fly   175 LR-----KLQTKPLTVFTAVMIWILAILLGMPSVL-FSDIKSYPVFTATGNMTIEVCSPFRDPEY 233

  Fly   266 AHVFAVSG--FIFFGGPMTAICVLYVLIGVKLKRSRLLQSLP--RRTFDANRGLNAQGRVIRMLV 326
            |. |.|:|  .:::..|::.|..||:::..:|..|  .:::|  :::..:.....|:..|.||:|
  Fly   234 AK-FMVAGKALVYYLLPLSIIGALYIMMAKRLHMS--ARNMPGEQQSMQSRTQARARLHVARMVV 295

  Fly   327 AVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPLLYNIM 391
            |..|.||:|:.|:|      |:.|.......:.:.|::::.:|........||::|:||:....:
  Fly   296 AFVVVFFICFFPYH------VFELWYHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCV 354

  Fly   392 SHKFREAFK-----ITLTRQFGLARNHHHQQSQHHQHNYSALLRQNGSMRLQPASCSVNNNALEP 451
            |..||:.|.     |.:.||..|           .||:.:..:..|.|:.....|..|...|
  Fly   355 SGVFRQHFNRYLCCICVKRQPHL-----------RQHSTATGMMDNTSVMSMRRSTYVGGTA--- 405

  Fly   452 YGSYRVVQFRCRDANHQLSLQDSIRTTTTTTTINSNSMAAGNGVGGGAGGGGGGRRLRKQEL--- 513
             |:.|....  |::||.:.                   .||.|||||.|.|..|...|:..:
  Fly   406 -GNLRASLH--RNSNHGVG-------------------GAGGGVGGGVGSGRVGSFHRQDSMPLQ 448

  Fly   514 ----YGPGPGTAVPHRMLQAQVSQLSSLGDANSLLEAEVVDRHYASGRAKRALLATKSGALLV 572
                :|.|.|            ...|.||               |.||. .|:...: |.|:|
  Fly   449 HGNAHGGGAG------------GGSSGLG---------------AGGRT-AAVSEKRXGTLIV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	42/130 (32%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	72/280 (26%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	84/309 (27%)
		TM helix 1	71..97	CDD:320593	12/25 (48%)
		TM helix 2	104..130	CDD:320593	7/26 (27%)
		TM helix 3	142..172	CDD:320593	9/29 (31%)
		TM helix 4	182..202	CDD:320593	6/19 (32%)
		TM helix 5	234..259	CDD:320593	8/25 (32%)
		TM helix 6	285..315	CDD:320593	14/35 (40%)
		TM helix 7	330..355	CDD:320593	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840