Protein Alignment PK2-R1 and GPR39

DIOPT Version :10

• Sequence 1: NP_731790.1
• Gene: PK2-R1 / 41639
• FlyBaseID: FBgn0038140
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_001499.1
• Gene: GPR39 / 2863
• HGNCID: 4496
• Length: 453
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 117/471 - (24%)
• Similarity: 190/471 - (40%)
• Gaps: 89/471 - (18%)

  Fly    85 STNGTNASTMAADSPVDE---SLTLRTALTVCYALIFVAGVLGNLIT---CIVISRNNFMHTATN 143
            |..|::.|.:...|.|.|   :..::..|.:.|.:|||.|:|||..|   ..|:.:..::.....
Human     5 SLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVT 69

  Fly   144 FYLFNLAVSDLILLVSGIPQELYN-LWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERY 207
            .::.:||.||:::.:.|:|.|.|: :|.|.........|.:.:.|.|..:.||:|.:...:.|||
Human    70 DHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERY 134

  Fly   208 IAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVY------QNEGYSCTMENDFYA 266
            ||||||||...:|...:....|..:|:.:.|:|||........|      .:.|.:|...:..:.
Human   135 IAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHH 199

  Fly   267 H------------------VFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPR------- 306
            .                  ||..|.|..|      :..|.||:.|......::|.|.:
Human   200 EQPETSNMSICTNLSSRWTVFQSSIFGAF------VVYLVVLLSVAFMCWNMMQVLMKSQKGSLA 258

  Fly   307 --------RTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFN 363
                    |..::.....|:.:.|..|..:.|...:||.|...:|:||.       .....|...
Human   259 GGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAA-------AKPKHDWTR 316

  Fly   364 DYFR---ILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNY 425
            .|||   ||...|...::||:.||||||.:.|.:||..|...|..:..|...:|.::.:.|.|:.
Human   317 SYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHST 381

  Fly   426 S------------ALLRQNGSMRLQPASCSVNNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTT 478
            :            |..||:.:.|.:....|...:..||           :..:..||| :|:...
Human   382 TDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEP-----------QSKSQSLSL-ESLEPN 434

  Fly   479 TTTTTINSNSMAAGNG 494
            :.....||   ||.||
Human   435 SGAKPANS---AAENG 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tmA_capaR	108..399	CDD:320262	88/336 (26%)
		TM helix 1	108..135	CDD:320262	11/29 (38%)
		TM helix 2	142..168	CDD:320262	8/26 (31%)
		TM helix 3	181..211	CDD:320262	11/29 (38%)
		TM helix 4	223..245	CDD:320262	6/21 (29%)
		TM helix 5	265..294	CDD:320262	8/46 (17%)
		TM helix 6	316..346	CDD:320262	8/29 (28%)
		TM helix 7	367..392	CDD:320262	12/27 (44%)
GPR39	NP_001499.1	7tmA_GPR39	31..355	CDD:320263	88/336 (26%)
		TM helix 1	31..58	CDD:320263	10/26 (38%)
		TM helix 2	68..94	CDD:320263	8/25 (32%)
		TM helix 3	108..138	CDD:320263	11/29 (38%)
		TM helix 4	150..172	CDD:320263	6/21 (29%)
		TM helix 5	217..246	CDD:320263	9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..274		1/18 (6%)
		TM helix 6	276..306	CDD:320263	8/29 (28%)
		TM helix 7	323..348	CDD:320263	11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..453		12/48 (25%)