DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment: PK2-R1 and NMUR1

Sequence 1:NP_731790.1 Gene:PK2-R1 FlyBaseID:FBgn0038140 Length:660 Species:Drosophila melanogaster
Sequence 2:NP_006047.3 Gene:NMUR1 HGNCID:4518 Length:426 Species:Homo sapiens

Alignment Length:367 Identity:125/368 (34%)
Similarity:191/368 (52%) Gaps:57/368 (15%)


  Fly   101 DESLTLR--------TALTVC--YALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLI 155
            ||:|.|:        ..:.:|  |.||||.|.:||.:||:||.|:..|.|.||:|||:||||||:
Human    44 DEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLL 108

  Fly   156 LLVSGIPQELYNLWYPDMYPFTDAM--CIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHT 218
            :|:.|:|.|||.:|:  .|||...:  |...::|.||...|:||.:||.:||||:|:.||.:..:
Human   109 VLLVGLPLELYEMWH--NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARS 171

  Fly   219 MSKLSRAIKFIFAIWLAAFLLALPQA-----MQFSVVYQN---EGYSCTM--ENDFYAHVFAVSG 273
            |...:...:.:.|:|..|.|.:||..     .|..|..:.   :...|.:  ....|..|...:.
Human   172 MVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTA 236

  Fly   274 FIFFGGPMTAICVLYVLIGVKLKRSRLL---------QSLPRRTFDANRGLNAQGR--VIRMLVA 327
            .:||..||..:.|||:|||::|:|.|||         .:..|..:......:.:||  |.:||..
Human   237 LLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFV 301

  Fly   328 VAVAFFLCWAPFHAQRLM-AVY-----GLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPL 386
            :.|.|.:|||||||.|:| :|.     ||:|.            |:.:...||:.::|.:..||:
Human   302 LVVVFGICWAPFHADRVMWSVVSQWTDGLHLA------------FQHVHVISGIFFYLGSAANPV 354

  Fly   387 LYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSAL 428
            ||::||.:|||.|:..|.    |....|..:.:|..|:.|.:
Human   355 LYSLMSSRFRETFQEALC----LGACCHRLRPRHSSHSLSRM 392

Known Domains:


GeneSequenceDomainRegion External IDIdentity
PK2-R1NP_731790.1 7tm_4 114..>242 CDD:304433 58/130 (45%)
7tm_1 124..388 CDD:278431 101/293 (34%)
NMUR1NP_006047.3 7tm_1 77..356 CDD:278431 101/293 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 C66678907
eggNOG 1 0.900 E33208_3BGH7
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 D380940at33208
OrthoFinder 1 1.000 FOG0001071
OrthoInspector 1 1.000 T130221
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 O PTHR24243
Phylome 1 0.910 0.800 Consistency score
RoundUp 1 1.030 avgDist Average_Evolutionary_Distance R5416
TreeFam 1 0.960
User_Submission 00.000 Not matched by this tool.
98.840

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