DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and Nmur2

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_071611.3	Gene:	Nmur2 / 64042	RGDID:	621155	Length:	395	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	121/342 - (35%)
Similarity:	193/342 - (56%)	Gaps:	39/342 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LTQVLNISADNLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRN 94
            |.:.||.:.:.|..|......:..||             :||.|||||:.||:|||:.|:||.|:
  Rat    14 LMKYLNSTEEYLAHLCGPKRSDLSLP-------------VSVAYALIFLVGVMGNLLVCMVIVRH 65

  Fly    95 NFMHTATNFYLFNLAISDMILLCSGMPQDLYNLWHPDNYP--FSDSICILESVLSETAANATVLT 157
            ..:.|.||:|||:||:||:::|..|||.::|.:||  |||  |....|..::.|.||...|::|:
  Rat    66 QTLKTPTNYYLFSLAVSDLLVLLLGMPLEIYEMWH--NYPFLFGPVGCYFKTALFETVCFASILS 128

  Fly   158 ITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALP----QAIQFSVVMQGM----G 214
            :|..:||||:||.||||....|...||::.:..:|..:::.:||    ..|:|.....|.    .
  Rat   129 VTTVSVERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQHFPNGSSVPGS 193

  Fly   215 TSCTMKNDFFAH--VFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNRGISAQ 277
            .:||:....:.:  :...:.|||:..|||.|.|||.|:|::|||...|:| .:...:::|  .::
  Rat   194 ATCTVTKPMWVYNLIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEA-NKVAVNIHR--PSR 255

  Fly   278 TRVIRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFND---VFSILDYTSGVLYFLSTCI 339
            ..|.:||..:.:.|.|||.|||..||.     .|.:| :|...   ||:::...|||.::||:.:
  Rat   256 KSVTKMLFVLVLVFAICWTPFHVDRLF-----FSFVE-EWTESLAAVFNLIHVVSGVFFYLSSAV 314

  Fly   340 NPLLYNIMSHKFREAFK 356
            ||::||::|.:||.||:
  Rat   315 NPIIYNLLSRRFRAAFR 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	98/275 (36%)
Nmur2	NP_071611.3	7tm_4	48..333	CDD:304433	108/295 (37%)
		7tm_1	54..319	CDD:278431	98/275 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338876
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8974
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810