Protein Alignment PK2-R2 and Gpr39

DIOPT Version :10

• Sequence 1: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_001107864.1
• Gene: Gpr39 / 288995
• RGDID: 1306745
• Length: 456
• Species: Rattus norvegicus
• Alignment Length: 456
• Identity: 113/456 - (24%)
• Similarity: 204/456 - (44%)
• Gaps: 75/456 - (16%)

  Fly    68 TLSVGYALIFIAGVLGNLIT---CIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYN-LW 128
            ||::.|.::|:.|:|||.:|   ..|:.:..::......::.:||.||:::...|||.:.|: :|
  Rat    32 TLTLVYLIVFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMISLACSDILVFLIGMPMEFYSIIW 96

  Fly   129 HPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWI 193
            :|...|.....|.|.:.|.||.:.||:|.:...:.|||||||||||...:|...:....|..:|:
  Rat    97 NPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFRYKDVSGPCQVKLLIGFVWV 161

  Fly   194 AALLLALP----QAIQFSV--VMQGMGTSCTMKND-----------------------FFAHVF- 228
            .:.|:|||    ..|::.:  |....|.:|.:...                       |.:.:|
  Rat   162 TSALVALPLLFAMGIEYPLANVPTHKGLNCNLSRTRHHDHPGDSNMSICTNLSSRWEVFQSSIFG 226

  Fly   229 AVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPR---RCYDVNRGISAQTRVIRMLVAVAVA 290
            |.:.:|.....:..:|...:.:.:|.||..|....|:   |..:.....:|:.:.|..|..:.|.
  Rat   227 AFAVYLVVLVSVAFMCWNMMKVLMKSKRGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVT 291

  Fly   291 FFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAF 355
            ..:||.|...:|:||...........:|.....:|.: |...::||:.:||||||:.|.:||:.|
  Rat   292 LAVCWMPNQIRRIMAAAKPKHDWTKSYFKAYMILLPF-SDTFFYLSSVVNPLLYNVSSQQFRKVF 355

  Fly   356 KVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTMTSMATTTTGLNGSANGSGN 420
            ...|.....|...||.:.....:|:.:         :::.|.|:.:..:|:.      .:|.|
  Rat   356 WQVLCCRLTLQHANQEKQQRAYFSSTK---------NSSRSARSPLIFLASR------RSNSS-- 403

  Fly   421 GTTTGQSVRLNRVSLDSVQ-----MQGQNRSRQDLFDNPRRMLQTQISQLSSVGDA--HSLLEED 478
                  |.|.|:|.|.:.|     ::|:::....  ::|    ||. |:....|.|  :||.|::
  Rat   404 ------SRRTNKVFLSTFQAEAKPLEGEHQPLSP--ESP----QTG-SETKPAGSATENSLQEQE 455

  Fly   479 L 479
            :
  Rat   456 V 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	85/322 (26%)
		TM helix 1	69..94	CDD:320262	9/27 (33%)
		TM helix 2	101..127	CDD:320262	8/26 (31%)
		TM helix 3	140..170	CDD:320262	13/29 (45%)
		TM helix 4	182..204	CDD:320262	6/25 (24%)
		TM helix 5	225..253	CDD:320262	4/28 (14%)
		TM helix 6	275..305	CDD:320262	8/29 (28%)
		TM helix 7	323..348	CDD:320262	10/24 (42%)
Gpr39	NP_001107864.1	7tmA_GPR39	31..355	CDD:320263	86/323 (27%)
		TM helix 1	31..58	CDD:320263	9/25 (36%)
		TM helix 2	68..94	CDD:320263	8/25 (32%)
		TM helix 3	108..138	CDD:320263	13/29 (45%)
		TM helix 4	150..172	CDD:320263	6/21 (29%)
		TM helix 5	217..246	CDD:320263	5/28 (18%)
		TM helix 6	276..306	CDD:320263	8/29 (28%)
		TM helix 7	323..348	CDD:320263	10/25 (40%)