DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and Gpr39

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001107864.1	Gene:	Gpr39 / 288995	RGDID:	1306745	Length:	456	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	113/456 - (24%)
Similarity:	204/456 - (44%)	Gaps:	75/456 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 TLSVGYALIFIAGVLGNLIT---CIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYN-LW 128
            ||::.|.::|:.|:|||.:|   ..|:.:..::......::.:||.||:::...|||.:.|: :|
  Rat    32 TLTLVYLIVFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMISLACSDILVFLIGMPMEFYSIIW 96

  Fly   129 HPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWI 193
            :|...|.....|.|.:.|.||.:.||:|.:...:.|||||||||||...:|...:....|..:|:
  Rat    97 NPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFRYKDVSGPCQVKLLIGFVWV 161

  Fly   194 AALLLALP----QAIQFSV--VMQGMGTSCTMKND-----------------------FFAHVF- 228
            .:.|:|||    ..|::.:  |....|.:|.:...                       |.:.:|
  Rat   162 TSALVALPLLFAMGIEYPLANVPTHKGLNCNLSRTRHHDHPGDSNMSICTNLSSRWEVFQSSIFG 226

  Fly   229 AVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPR---RCYDVNRGISAQTRVIRMLVAVAVA 290
            |.:.:|.....:..:|...:.:.:|.||..|....|:   |..:.....:|:.:.|..|..:.|.
  Rat   227 AFAVYLVVLVSVAFMCWNMMKVLMKSKRGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVT 291

  Fly   291 FFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAF 355
            ..:||.|...:|:||...........:|.....:|.: |...::||:.:||||||:.|.:||:.|
  Rat   292 LAVCWMPNQIRRIMAAAKPKHDWTKSYFKAYMILLPF-SDTFFYLSSVVNPLLYNVSSQQFRKVF 355

  Fly   356 KVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTMTSMATTTTGLNGSANGSGN 420
            ...|.....|...||.:.....:|:.:         :::.|.|:.:..:|:.      .:|.|
  Rat   356 WQVLCCRLTLQHANQEKQQRAYFSSTK---------NSSRSARSPLIFLASR------RSNSS-- 403

  Fly   421 GTTTGQSVRLNRVSLDSVQ-----MQGQNRSRQDLFDNPRRMLQTQISQLSSVGDA--HSLLEED 478
                  |.|.|:|.|.:.|     ::|:::....  ::|    ||. |:....|.|  :||.|::
  Rat   404 ------SRRTNKVFLSTFQAEAKPLEGEHQPLSP--ESP----QTG-SETKPAGSATENSLQEQE 455

  Fly   479 L 479
            :
  Rat   456 V 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	74/297 (25%)
Gpr39	NP_001107864.1	7tm_1	47..344	CDD:278431	74/297 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920