Protein Alignment PK2-R2 and MLNR

DIOPT Version :10

• Sequence 1: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_001498.1
• Gene: MLNR / 2862
• HGNCID: 4495
• Length: 412
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 121/408 - (29%)
• Similarity: 183/408 - (44%)
• Gaps: 88/408 - (21%)

  Fly    62 PLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYN 126
            ||..|..::.....:|:.||.||::|.::|.|...|.|.||.||.::|:||:::|. |:|.|||.
Human    34 PLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILL-GLPFDLYR 97

  Fly   127 LWHPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAI 191
            ||....:.|...:|.|...:.|....||:|.:||.:||||:|||.|.|...:....|....|..:
Human    98 LWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVL 162

  Fly   192 WIAALLLALPQAIQFSV-------VMQGMGTSCTMKNDFFAH----------------------- 226
            |..|||.|.|......|       |:.|:..:..:.:...|.
Human   163 WAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEA 227

  Fly   227 ---------------------VFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDV 270
                                 ::..:.:.|.  |...:.:||.|||.:|..||  :.|
Human   228 AALFSRECRPSPAQLGALRVMLWVTTAYFFL--PFLCLSILYGLIGRELWSSR--RPL------- 281

  Fly   271 NRGISAQTR------VIRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDYTS 329
             ||.:|..|      .:|:|:.|.:||.|||.|||..|:  :|.:|......:|:..|:|:...
Human   282 -RGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRI--IYINTEDSRMMYFSQYFNIVALQ- 342

  Fly   330 GVLYFLSTCINPLLYNIMSHKFR-EAFKVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHT 393
              |::||..|||:|||::|.|:| .|||:.|||      |::.||...:     |:..|.:...|
Human   343 --LFYLSASINPILYNLISKKYRAAAFKLLLAR------KSRPRGFHRS-----RDTAGEVAGDT 394

  Fly   394 -TDSVRTTMTSMATTTTG 410
             .|:|..|.||....|.|
Human   395 GGDTVGYTETSANVKTMG 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	99/343 (29%)
		TM helix 1	69..94	CDD:320262	7/24 (29%)
		TM helix 2	101..127	CDD:320262	13/25 (52%)
		TM helix 3	140..170	CDD:320262	13/29 (45%)
		TM helix 4	182..204	CDD:320262	8/21 (38%)
		TM helix 5	225..253	CDD:320262	8/71 (11%)
		TM helix 6	275..305	CDD:320262	14/35 (40%)
		TM helix 7	323..348	CDD:320262	10/24 (42%)
MLNR	NP_001498.1	7tm_GPCRs	39..366	CDD:475119	99/344 (29%)
		TM helix 1	41..65	CDD:410628	7/23 (30%)
		TM helix 2	74..95	CDD:410628	9/21 (43%)
		TM helix 3	112..134	CDD:410628	7/21 (33%)
		TM helix 4	157..173	CDD:410628	6/15 (40%)
		TM helix 5	245..268	CDD:410628	3/24 (13%)
		TM helix 6	297..319	CDD:410628	11/21 (52%)
		TM helix 7	334..359	CDD:410628	11/27 (41%)