Protein Alignment PK2-R2 and Nmur2

DIOPT Version :10

• Sequence 1: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_694719.2
• Gene: Nmur2 / 216749
• MGIID: 2441765
• Length: 395
• Species: Mus musculus
• Alignment Length: 333
• Identity: 120/333 - (36%)
• Similarity: 191/333 - (57%)
• Gaps: 28/333 - (8%)

  Fly    39 DNLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNF 103
            |:|...|.  ..||.|..:.......|...:||.|||||:.||:|||:.|:||:|:..:.|.||:
Mouse    12 DSLMKYLN--STEEYLAYLCGPKRSDLSLPVSVVYALIFVVGVIGNLLVCLVIARHQTLKTPTNY 74

  Fly   104 YLFNLAISDMILLCSGMPQDLYNLWHPDNYP--FSDSICILESVLSETAANATVLTITAFTVERY 166
            |||:||:||:::|..|||.::|.|||  |||  |....|..::.|.||...|::|::|..::|||
Mouse    75 YLFSLAVSDLLVLLLGMPLEVYELWH--NYPFLFGPVGCYFKTALFETVCFASILSVTTVSIERY 137

  Fly   167 IAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALP----QAIQFSVVMQGM----GTSCTMKNDF 223
            :||.||||....|...||::.:..:|..:::.:||    ..|:|.....|.    ..:||:....
Mouse   138 VAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQQFPNGSSVPGSATCTVTKPI 202

  Fly   224 FAHVFAV--SGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNRGISAQTRVIRMLVA 286
            :.:.|.:  :.|||:..|||.|.|||.|:|::|||...|:| .:...:::|  .::..|.:||..
Mouse   203 WVYNFIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEA-DKVTVNIHR--PSRKSVTKMLFV 264

  Fly   287 VAVAFFICWAPFHAQRLMAVYGSTSGIESQWFND---VFSILDYTSGVLYFLSTCINPLLYNIMS 348
            :.:.|.|||.|||..||...:      ..:|...   ||:::...|||.::||:.:||::||::|
Mouse   265 LVLVFAICWTPFHVDRLFFSF------VDEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLS 323

  Fly   349 HKFREAFK 356
            .:||.||:
Mouse   324 RRFRAAFR 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	111/300 (37%)
		TM helix 1	69..94	CDD:320262	15/24 (63%)
		TM helix 2	101..127	CDD:320262	14/25 (56%)
		TM helix 3	140..170	CDD:320262	11/29 (38%)
		TM helix 4	182..204	CDD:320262	5/25 (20%)
		TM helix 5	225..253	CDD:320262	13/29 (45%)
		TM helix 6	275..305	CDD:320262	12/29 (41%)
		TM helix 7	323..348	CDD:320262	9/24 (38%)
Nmur2	NP_694719.2	7tm_GPCRs	38..330	CDD:475119	111/302 (37%)
		TM helix 1	40..64	CDD:320479	15/23 (65%)
		TM helix 2	73..95	CDD:320479	12/21 (57%)
		TM helix 3	112..134	CDD:320479	6/21 (29%)
		TM helix 4	157..173	CDD:320479	2/15 (13%)
		TM helix 5	206..229	CDD:320479	10/22 (45%)
		TM helix 6	259..281	CDD:320479	9/21 (43%)
		TM helix 7	298..323	CDD:320479	9/24 (38%)
		NmU-R2_C_term	323..389	CDD:466027	5/9 (56%)