DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and nmur-2

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_493666.2	Gene:	nmur-2 / 173398	WormBaseID:	WBGene00019616	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	125/387 - (32%)
Similarity:	187/387 - (48%)	Gaps:	68/387 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLC 117
            ::|||             :.|..||:.|:.||:.|||||:.|..||..||:|||:||:||:|.|.
Worm    31 VIPTV-------------IIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVSDIIALI 82

  Fly   118 SGMPQDLY-NLWHPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKL 181
            .|:|.:.| :|.:...|.||:.||...:.|.|..:.|:::.|..|:.||::|||||.|....|.|
Worm    83 LGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHPLRSKIFSTL 147

  Fly   182 SRAVKFIFAIWIAALLLALPQA--IQFSVV-------MQGMGTSCTMKNDFFAH----------- 226
            .||...|...|..:.:.|||.|  :|.:.:       .|......:....|..|
Worm   148 WRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLHTEFCAMNQSRP 212

  Fly   227 -------VFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRL----LQALPRRCYDVNRGISAQTRV 280
                   :||.:  :||..|..||.::|..|.|:|:.|.:    .:.:.:|....||      .|
Worm   213 DQQKMIIIFAFT--VFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRNKSNR------TV 269

  Fly   281 IRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILD----YTSGVLYFLSTCINP 341
            ::||::|.:.|||||.|||.|||::||  |:..|:...:.....|.    |.||..|:.::..||
Worm   270 LKMLLSVVITFFICWLPFHIQRLLSVY--TTWSETTTISPPVQFLSMIVFYISGFCYYSNSAANP 332

  Fly   342 LLYNIMSHKFREAF-KVTLARHFG----LGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVR 398
            :||||:|.|:|.|| :..|..|..    .|.:..|:....:.|.....:|    |.|..|||
Worm   333 ILYNILSQKYRSAFCRTILGDHIANFVFKGHQRPGQSKRCSSSTEAEQRT----LMTRGSVR 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	98/296 (33%)
nmur-2	NP_493666.2	7tmA_capaR	32..346	CDD:320262	112/336 (33%)
		TM helix 1	34..58	CDD:320262	13/36 (36%)
		TM helix 2	67..89	CDD:320262	12/21 (57%)
		TM helix 3	107..129	CDD:320262	5/21 (24%)
		TM helix 4	152..168	CDD:320262	4/15 (27%)
		TM helix 5	216..239	CDD:320262	7/24 (29%)
		TM helix 6	267..292	CDD:320262	14/30 (47%)
		TM helix 7	314..339	CDD:320262	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.910