DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and ntsr2

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_017949971.1	Gene:	ntsr2 / 101730337	XenbaseID:	XB-GENE-22068810	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	430	Identity:	115/430 - (26%)
Similarity:	202/430 - (46%)	Gaps:	101/430 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 TPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHT---ATNFYLFNLAISDMILLCSGMPQ 122
            |..|....::|.|.|||:.|.:||::|..::.:.:..|.   ..:::|.::|:||:::|...:|.
Frog    31 THFSSKVFITVFYILIFLVGTIGNVLTIRLVLKKHNRHKLQGTVHYHLVSMALSDILILLISIPI 95

  Fly   123 DLYN-LWHPDNYP--FSDSICILESVLSETAANATVLTITAFTVERYIAICHPF-RQHTMSKLSR 183
            :||| :|  .:||  |.|::|.....|.:..:.||||.||:.:.|||:|||||. .:..|||: |
Frog    96 ELYNFIW--VHYPWIFGDAVCRSYYFLRDICSYATVLNITSLSCERYLAICHPMTAKRIMSKM-R 157

  Fly   184 AVKFIFAIWIAALLLALPQA----IQF------------SVVMQGMGTSCTMKNDFFAHVF-AVS 231
            ..|.:..||.::::.|:|.|    :::            |::...:.::.|:|      || .|:
Frog   158 TKKILSVIWFSSVVFAMPMAFIMGVKYENTTPEGEEDPSSLICTNLVSTATLK------VFIQVN 216

  Fly   232 GFLFFGGPMTAI-CVLYVLIG-VKLKRSRLLQAL------PRRCYDVN---RGISAQTRV----- 280
            .|:.|..|:..| |:..|.:. ::..|||...:|      |:..|..:   :.:|:...|
Frog   217 VFVSFLLPLALISCLNCVTVNQLESLRSRYFLSLHSSSKAPQASYRAHVSLKPVSSSPAVKKLSV 281

  Fly   281 ------------------------IRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDV 321
                                    |.||.|:.:|:.:||.|:||:|||..|..    :..|...:
Frog   282 AGATSKSSLTVSCEPNRIQPIQHSIYMLRAIVIAYVVCWLPYHARRLMFCYIP----DDYWTGFL 342

  Fly   322 FSILDY---TSGVLYFLSTCINPLLYNIMSHKFREAFKVTLARHFGLGGKNQGRGLPHTYSALRR 383
            ::...|   .:..|:::|:.:||:|||::|..|||.|..||.                 :|..|:
Frog   343 YTFYHYFYMLTNTLFYVSSAVNPILYNMVSSSFRELFLETLG-----------------FSRRRK 390

  Fly   384 NQ--TGSLRLHTTDSVRTTMTSMATTTTGLNGSANGSGNG 421
            .|  ..|:.|.|  |:|:...::.|.|.....|...:.||
Frog   391 EQQLNSSVSLQT--SLRSDTCTLHTPTNHRQASREETANG 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	84/327 (26%)
ntsr2	XP_017949971.1	7tm_GPCRs	36..379	CDD:391938	97/355 (27%)
		TM helix 1	38..63	CDD:341315	9/24 (38%)
		TM helix 2	75..97	CDD:341315	6/21 (29%)
		TM helix 3	115..137	CDD:341315	7/21 (33%)
		TM helix 4	160..176	CDD:341315	4/15 (27%)
		TM helix 5	210..233	CDD:341315	9/28 (32%)
		TM helix 6	303..328	CDD:341315	10/24 (42%)
		TM helix 7	347..372	CDD:341315	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020