Protein Alignment 2mit and PODN

DIOPT Version :10

• Sequence 1: NP_001262529.1
• Gene: 2mit / 41616
• FlyBaseID: FBgn0260793
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_714914.3
• Gene: PODN / 127435
• HGNCID: 23174
• Length: 613
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 138/508 - (27%)
• Similarity: 217/508 - (42%)
• Gaps: 104/508 - (20%)

  Fly    33 DIPT-SSRLAAEREE-QQLSRQDVGRLSYQSIHRM--LRDENEPDSFRGELRYQQKRHKRELE-L 92
            |:|. ::.|:.:..: :::..:::.||     ||:  |..:|...:.|| |..:...|...|. |
Human    93 DLPEHTNHLSLQNNQLEKIYPEELSRL-----HRLETLNLQNNRLTSRG-LPEKAFEHLTNLNYL 151

  Fly    93 NAPANKLNLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLESLSLDNFNQ---LRQLDLGNNSL 154
            ....|||.|..|.|.             ..:.::|.::|.|..:....|.|   ||.:.|.||
Human   152 YLANNKLTLAPRFLP-------------NALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNN-- 201

  Fly   155 EVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQ-----LKNLNLAHNELLNISRESFY 214
                 .|||.  .||....:.|.|....|.:|.|.:.:|:     |..|:|.:|:|..|...:|.
Human   202 -----KLADA--GLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFS 259

  Fly   215 NLLELQTLVLSHNNISD--IDYETFLALPNLQYLDLSHNRLSGSAIRALQGIP-DLVSLSIAYNP 276
            .|..|:.|.|.:|.::|  :|.|||..|.:|:|||||.|.||    |...|:| .||.|.:..|.
Human   260 ELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLS----RVPAGLPRSLVLLHLEKNA 320

  Fly   277 --------------------------DVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTL 315
                                      :.|:....|.....|..:......|.:||:.|.:.||||
Human   321 IRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTL 385

  Fly   316 KLSDNWLKAINCGDMDSYPLLQYLDLSHSRIA--QVEDDALGRLELLESLFLDRNLLMRVPSSLP 378
            .:..|.:..|...|..:...|:.|:||::||.  ||..||..:|.||.||.|..|.|..:|..||
Human   386 MILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLP 450

  Fly   379 ------------------------PSLEHLFLQHNQIME--LPPQAFVGLVNLQTLDLSNNRLIF 417
                                    ..|..|:|..|::..  |.|:|:|.|.:||.||::.|:|..
Human   451 RNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTE 515

  Fly   418 LPPLSLPKLLT-LNLESSGVESVSQSIVHTLPQLRDLLLEDNPIKCSDLLGIA 469
            :|. .||:.|. |.|:::.:.:|..:...:.|.|:.:.|..|.:....::..|
Human   516 IPE-GLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSA 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR	<106..458	CDD:443914	116/417 (28%)
		leucine-rich repeat	124..143	CDD:275380	4/18 (22%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..194	CDD:275380	5/21 (24%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	10/24 (42%)
		leucine-rich repeat	243..311	CDD:275380	23/94 (24%)
		leucine-rich repeat	312..335	CDD:275380	7/22 (32%)
		leucine-rich repeat	336..359	CDD:275380	11/24 (46%)
		leucine-rich repeat	360..380	CDD:275380	9/43 (21%)
		leucine-rich repeat	381..404	CDD:275380	9/24 (38%)
		leucine-rich repeat	405..449	CDD:275380	13/44 (30%)
PODN	NP_714914.3	LRRNT	68..98	CDD:214470	2/4 (50%)
		leucine-rich repeat	79..96	CDD:275380	1/2 (50%)
		LRR 1	97..118		1/20 (5%)
		leucine-rich repeat	100..121	CDD:275380	3/25 (12%)
		LRR	<107..372	CDD:443914	76/296 (26%)
		LRR 2	121..141		6/20 (30%)
		leucine-rich repeat	122..147	CDD:275380	6/25 (24%)
		LRR 3	147..168		8/33 (24%)
		leucine-rich repeat	148..192	CDD:275380	13/56 (23%)
		LRR 4	169..189		4/19 (21%)
		PLN00113	181..>588	CDD:215061	114/401 (28%)
		LRR 5	192..212		10/28 (36%)
		leucine-rich repeat	193..218	CDD:275380	11/33 (33%)
		LRR 6	218..238		5/19 (26%)
		leucine-rich repeat	219..239	CDD:275380	4/19 (21%)
		LRR 7	239..260		7/20 (35%)
		leucine-rich repeat	240..263	CDD:275380	8/22 (36%)
		LRR 8	263..283		6/19 (32%)
		leucine-rich repeat	264..289	CDD:275380	10/24 (42%)
		LRR 9	289..310		12/24 (50%)
		leucine-rich repeat	290..310	CDD:275380	12/23 (52%)
		leucine-rich repeat	311..334	CDD:275380	4/22 (18%)
		LRR 10	311..331		4/19 (21%)
		LRR 11	334..357		2/22 (9%)
		leucine-rich repeat	335..360	CDD:275380	2/24 (8%)
		LRR 12	360..380		5/19 (26%)
		LRR 13	381..402		7/20 (35%)
		leucine-rich repeat	385..405	CDD:275380	4/19 (21%)
		LRR 14	405..426		9/20 (45%)
		leucine-rich repeat	406..476	CDD:275380	21/69 (30%)
		LRR 15	431..452		10/20 (50%)
		LRR 16	476..489		4/12 (33%)
		leucine-rich repeat	477..502	CDD:275380	9/24 (38%)
		LRR 17	502..522		8/20 (40%)
		leucine-rich repeat	503..523	CDD:275380	9/20 (45%)
		LRR 18	523..544		4/20 (20%)
		leucine-rich repeat	524..547	CDD:275380	4/22 (18%)
		LRR 19	547..568		4/21 (19%)
		leucine-rich repeat	548..571	CDD:275380	4/20 (20%)
		LRR 20	573..595
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	588..613