Protein Alignment 2mit and lrrc4b

DIOPT Version :10

• Sequence 1: NP_001262529.1
• Gene: 2mit / 41616
• FlyBaseID: FBgn0260793
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001096358.1
• Gene: lrrc4b / 100124949
• XenbaseID: XB-GENE-5945982
• Length: 641
• Species: Xenopus tropicalis
• Alignment Length: 522
• Identity: 131/522 - (25%)
• Similarity: 204/522 - (39%)
• Gaps: 101/522 - (19%)

  Fly   198 LNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQ 262
            |||..|.:..|..::|.:|..|:.|.||.|.|..|:...|..||||..|:|..|||:....:|.:
 Frog    76 LNLQENIIQVIKTDTFKHLRHLEILQLSKNLIRKIEVGAFNGLPNLSTLELFDNRLTTVPTQAFE 140

  Fly   263 GIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSD-NWLKAIN 326
            .:..|..|.:..||      .|.:.|::..          :||     |:|.|.|.: ..|:.|:
 Frog   141 YLSKLRELWLRNNP------IESIPSYAFN----------RVP-----SLRRLDLGELKKLEYIS 184

  Fly   327 CGDMDSYPLLQYLDLSHSRIAQVED-DALGRLELLESLFLDRNLLMRV-PSSLP--PSLEHLFLQ 387
            ....:....|:||:|....:..:.: .||.|||.||   |..|.|..: |.|..  .||..|:|.
 Frog   185 EAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELE---LSGNRLEMIRPGSFQGLTSLRKLWLM 246

  Fly   388 HNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPLSLPKLLTLNLESSGVESVSQSIVHTLPQLRD 452
            |..:..:...||..|.:|:.|:||:|.|:.||                     ..:...|.:|..
 Frog   247 HAHVTIIERNAFDDLKSLEELNLSHNNLMSLP---------------------HDLFTPLHRLER 290

  Fly   453 LLLEDNPIKCS-DLLGIAEWASPCRSVDAGQSNGASVSGRVDLKTEYL----QFHNFYENFSSRE 512
            :.|..||..|: |:|.::.|..  .:|....:..|......:||..|:    |.|     |:...
 Frog   291 VHLNHNPWHCNCDVLWLSWWLK--ETVPNNTTCCARCHSPPNLKMRYIGELDQSH-----FTCYA 348

  Fly   513 CGIRKPEND---TKPPSCSL-TRASATLTT----TPRSMSKVEKSQEAQATATSVEVAAATAATS 569
            ..|.:|..|   |:..:..| .|...::|:    ||........|..       |.::.....|.
 Frog   349 PVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYR-------VRISVLHDGTL 406

  Fly   570 EKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQSAGNIPAQLTTKTLRPTET 634
            ..|.:......|.|         .:.|.::.:||||.||..:||...|.......||.|:. |..
 Frog   407 NFTNVTVQDTGQYT---------CMVTNSAGNTTATATLNVSAAADPATTDYTYFTTVTVE-TMD 461

  Fly   635 TSLAQLQRRQQMPGMPAKTT------ETPAKNLPSLAQTKATTALP-------ILATRDAATATT 686
            :::.:.:...:.|| |..|.      .|.:....|...|:.|..:|       |:...|....||
 Frog   462 SNVEETKPTDKEPG-PTPTVRWGITYSTTSLTPRSTRSTEKTFTIPITDVTGNIMKDLDDVMKTT 525

  Fly   687 EI 688
            :|
 Frog   526 KI 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR	<106..458	CDD:443914	74/264 (28%)
		leucine-rich repeat	124..143	CDD:275380
		leucine-rich repeat	144..167	CDD:275380
		leucine-rich repeat	172..194	CDD:275380
		leucine-rich repeat	195..218	CDD:275380	7/19 (37%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		leucine-rich repeat	243..311	CDD:275380	15/67 (22%)
		leucine-rich repeat	312..335	CDD:275380	5/23 (22%)
		leucine-rich repeat	336..359	CDD:275380	8/23 (35%)
		leucine-rich repeat	360..380	CDD:275380	7/22 (32%)
		leucine-rich repeat	381..404	CDD:275380	7/22 (32%)
		leucine-rich repeat	405..449	CDD:275380	9/43 (21%)
lrrc4b	NP_001096358.1	LRRNT	42..75	CDD:214470
		LRR	<72..319	CDD:443914	81/289 (28%)
		leucine-rich repeat	73..96	CDD:275380	7/19 (37%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	8/43 (19%)
		leucine-rich repeat	169..193	CDD:275380	5/23 (22%)
		leucine-rich repeat	194..215	CDD:275380	6/20 (30%)
		leucine-rich repeat	216..239	CDD:275380	9/25 (36%)
		leucine-rich repeat	240..263	CDD:275380	7/22 (32%)
		leucine-rich repeat	264..285	CDD:275380	8/41 (20%)
		LRRCT	296..346	CDD:214507	14/56 (25%)
		I-set	349..438	CDD:400151	22/104 (21%)
		Ig strand B	366..370	CDD:409353	1/3 (33%)
		Ig strand C	378..382	CDD:409353	0/3 (0%)
		Ig strand E	404..408	CDD:409353	1/3 (33%)
		Ig strand F	418..423	CDD:409353	2/13 (15%)
		Ig strand G	431..434	CDD:409353	2/2 (100%)