Protein Alignment Su(fu) and SUFU

DIOPT Version :10

• Sequence 1: NP_536750.2
• Gene: Su(fu) / 41565
• FlyBaseID: FBgn0005355
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: XP_011538160.1
• Gene: SUFU / 51684
• HGNCID: 16466
• Length: 527
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 180/531 - (33%)
• Similarity: 255/531 - (48%)
• Gaps: 128/531 - (24%)

  Fly    15 PPGLKAIIDHLGQVYPNQPNPLQVTTLLKYWLGGQDPLDYISMYNYPGDVDRNVPPHWHYISFGL 79
            ||||.||.....::||:||||||||.::||||||.|||||:|||...|....|:|.|||||||||
Human    31 PPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGL 95

  Fly    80 SDLHGDERVHLREEGVTRSGMGFELTFRLAKTEIELKQQIENPEKPQRPPTWPANLLQAIGRYCF 144
            |||:||.|||........||.||||||||.:...|           ..||||||.|:|.:.||.|
Human    96 SDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGE-----------SAPPTWPAELMQGLARYVF 149

  Fly   145 QTGNGLCFGDNIPWRKSLDGSTTSKLQNLLVAQDPQLGCIDTPTGTVDFCQIVGVFDDELEQASR 209
            |:.|..|.||::.|...||.| .|::|::|:.:|||:..:.||.|.|.|.|||||..:||..|.:
Human   150 QSENTFCSGDHVSWHSPLDNS-ESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQ 213

  Fly   210 WNGRGVLNFLRQDMQTGGDWLVTNMDRQMSVFELFPETLLNLQDD-----LEKQGSDLAGVNADF 269
            |||:|:|..||.....||.||:|:|.|..::||:.|    :||.:     :|..||:|:||:|..
Human   214 WNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDP----HLQQERVDKGIETDGSNLSGVSAKC 274

  Fly   270 TFRELKPTKEVKEEVDFQALSEKCANDENNRQL-----------TDTQMKRE----------EPS 313
            .:.:|....|               :||::|.:           .||:..||          :|.
Human   275 AWDDLSRPPE---------------DDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPV 324

  Fly   314 FPQSMSMSSNSL-HKSCPL---DFQAQAPNCI---------SLDGIEITLAPGVAKYLLLAIKDR 365
            .|.......|.| |...|.   ..::.:...|         .|:.:.:.........:.|.::.|
Human   325 LPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGR 389

  Fly   366 IRHGRHFTFKA--QHLALTLVAESVTGSAVTVNEPYGVLGYWIQ--------------------- 407
            :.||||||:|:  ..:|:|.|:..|.|:..|...||...|.|:|
Human   390 LLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQRPPSCELPSRPVCSPSCVHSF 454

  Fly   408 ---------------------VLIPDELVPRLMEDFRSAGLDEKCEPKE-RL--ELEWPDKNLK- 447
                                 :|:.:|.|.:::||     |::...|:| :|  |..||:|.||
Human   455 LVISQRGNFCSWQLTIPRGNLILLTEEFVEKMLED-----LEDLTSPEEFKLPKEYSWPEKKLKV 514

  Fly   448 -----LIIDQP 453
                 ::.|.|
Human   515 SILPDVVFDSP 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(fu)	NP_536750.2	SUFU	48..237	CDD:461543	92/188 (49%)
		SUFU_C	250..450	CDD:463598	61/291 (21%)
SUFU	XP_011538160.1	SUFU	64..240	CDD:461543	92/187 (49%)
		SUFU_C	254..516	CDD:463598	59/281 (21%)