Protein Alignment Su(fu) and Sufu

DIOPT Version :10

• Sequence 1: NP_536750.2
• Gene: Su(fu) / 41565
• FlyBaseID: FBgn0005355
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_056567.2
• Gene: Sufu / 24069
• MGIID: 1345643
• Length: 485
• Species: Mus musculus
• Alignment Length: 514
• Identity: 189/514 - (36%)
• Similarity: 264/514 - (51%)
• Gaps: 92/514 - (17%)

  Fly     1 MAEANLDKKPEVKP--------------------PPGLKAIIDHLGQVYPNQPNPLQVTTLLKYW 45
            |||.    :|.|.|                    ||||.||.....::||:||||||||.::|||
Mouse     1 MAEL----RPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYW 61

  Fly    46 LGGQDPLDYISMYNYPGDVDRNVPPHWHYISFGLSDLHGDERVHLREEGVTRSGMGFELTFRLAK 110
            |||.|||||:|||...|....|:|.||||||||||||:||.|||........||.||||||||.:
Mouse    62 LGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKR 126

  Fly   111 TEIELKQQIENPEKPQRPPTWPANLLQAIGRYCFQTGNGLCFGDNIPWRKSLDGSTTSKLQNLLV 175
            ...|           ..||||||.|:|.:.||.||:.|..|.||::.|...||.| .|::|::|:
Mouse   127 ETGE-----------SAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNS-ESRIQHMLL 179

  Fly   176 AQDPQLGCIDTPTGTVDFCQIVGVFDDELEQASRWNGRGVLNFLRQDMQTGGDWLVTNMDRQMSV 240
            .:|||:..:.||.|.|.|.|||||..:||..|.:|||:|:|..||.....||.||:|:|.|..::
Mouse   180 TEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETI 244

  Fly   241 FELFPETLLNLQDD-----LEKQGSDLAGVNADFTFRELKPTKEVKEEVDFQALSEKCANDENNR 300
            ||:.|    :||.:     :|..||:|:||:|...:.:|....|.:|:      |.........|
Mouse   245 FEIDP----HLQQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEED------SRSICLGTQPR 299

  Fly   301 QLT--DTQMKRE----------EPSFPQSMSMSSNSL-HKSCPL--------DFQAQAPNCI--- 341
            :|:  ||:..||          :|..|...|...|.| |...|.        ...|..|:.:
Mouse   300 RLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRT 364

  Fly   342 -SLDGIEITLAPGVAKYLLLAIKDRIRHGRHFTFKA--QHLALTLVAESVTGSAVTVNEPYGVLG 403
             .|:.:.:.........:.|.::.|:.||||||:|:  ..:|:|.|:..|.|:..|...||...|
Mouse   365 RQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHG 429

  Fly   404 YWIQVLIPDELVPRLMEDFRSAGLDEKCEPKE-RL--ELEWPDKNLK------LIIDQP 453
            .|:|:|:.:|.|.:::||     |::...|:| :|  |..||:|.||      ::.|.|
Mouse   430 PWLQILLTEEFVEKMLED-----LEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSP 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(fu)	NP_536750.2	SUFU	48..237	CDD:461543	92/188 (49%)
		SUFU_C	250..450	CDD:463598	64/240 (27%)
Sufu	NP_056567.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		6/23 (26%)
		SUFU	64..240	CDD:461543	92/187 (49%)
		SUFU_C	254..474	CDD:463598	62/230 (27%)
		Disordered. /evidence=ECO:0000250|UniProtKB:Q9UMX1	280..361		18/86 (21%)