Protein Alignment CG5961 and FBXO9

DIOPT Version :10

• Sequence 1: NP_650206.1
• Gene: CG5961 / 41541
• FlyBaseID: FBgn0038056
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_036479.1
• Gene: FBXO9 / 26268
• HGNCID: 13588
• Length: 447
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 163/453 - (35%)
• Similarity: 239/453 - (52%)
• Gaps: 43/453 - (9%)

  Fly     2 SDVDSDGEEPTRKTGTNALDEFRENWQRELQE--HTTNTGSRSHSEAGDRL--TAANSNLSEADL 62
            :|.|.:.|.|........|..||..|..||..  .::|..:|....|...|  |:|::...:...
Human    25 ADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQA 89

  Fly    63 LQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRF-YEQQKQKLSNDVSKKYLNLAND 126
            .:.||..|:..||:.||.|.:|:|:.|||:|.|:||||||:. |.:...  .:.|...|:...:|
Human    90 KEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPD--GDGVGNSYIEDNDD 152

  Fly   127 LAKQLDLGQSDGEEVVDNLYEKFQHDLR-QKNIYNGKMIASSRDANVLTTGLHFADLPPEIVMRI 190
            .:|..|            |...||..|. |:::.  |:.....:    ::.:|.:.||.|::|.|
Human   153 DSKMAD------------LLSYFQQQLTFQESVL--KLCQPELE----SSQIHISVLPMEVLMYI 199

  Fly   191 LRWVVSAQLDMRSLEQCAAVCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFHSWRD 255
            .|||||:.||:|||||.:.||:|||:.|||.|:|||||:||||.:...|..        :.|||:
Human   200 FRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVP--------YTSWRE 256

  Fly   256 MFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADEPAQG 320
            ||:.|.||.|:|.|||||||:|.||.|. |.|||....|||||||||.|||.|:|:||.:||...
Human   257 MFLERPRVRFDGVYISKTTYIRQGEQSL-DGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSI 320

  Fly   321 VSKLKHVNNVRAEMLRGRYRLFGST-----VTLVLQKSQQRGPANVRQRRGSIMPVDEDSSQFLI 380
            |.:|:..|.....:|.|.|||...|     |..|:.|.::..|.:.:.|....:||.|....|.:
Human   321 VPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHV 385

  Fly   381 ELRIAGTTKRRCAQLVWSHYT--LVQKRNKVDISSEFDLTEAKYPALRFSTVKSYHLDADAPL 441
            .|::..:..:|..:|:|.|::  :..|.......|.|:: :..|..|.|:.|:||...::.||
Human   386 GLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVSAFEI-DKMYTPLFFARVRSYTAFSERPL 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5961	NP_650206.1	MIT	74..131	CDD:469712	23/57 (40%)
		F-box_FBXO9	177..230	CDD:438861	32/52 (62%)
		FBO_C	252..>346	CDD:466021	52/98 (53%)
FBXO9	NP_036479.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..36		4/10 (40%)
		MIT	92..>123	CDD:461228	14/30 (47%)
		TPR	94..127		16/32 (50%)
		F-box_FBXO9	186..239	CDD:438861	32/52 (62%)
		FBO_C	253..>345	CDD:466021	51/92 (55%)