DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18549 and srw-59

DIOPT Version :9

Sequence 1:	NP_650203.3	Gene:	CG18549 / 41538	FlyBaseID:	FBgn0038053	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_506996.1	Gene:	srw-59 / 186771	WormBaseID:	WBGene00005806	Length:	349	Species:	Caenorhabditis elegans

Alignment Length:	284	Identity:	58/284 - (20%)
Similarity:	105/284 - (36%)	Gaps:	74/284 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FVFTAFQTMCNIEKTILDSISQEDDTFKGEGYTSLAIIYLFFSLSNWLAPSFISFTGPRVAMVVG 81
            |:|..|        |.:..:.|:...:.|.....|.:|.|.:||| ..|.:.||.......:.|.
Worm   110 FLFVHF--------TPIPRVFQDLAVWFGVAMAVLRVIILKYSLS-LKAQNLISSNSGIWILFVV 165

  Fly    82 ALTYTAFMITFMFPSTVLLYVGSAVLGLG-ASITWT--------GQGTYLARCSESSTISRNSGV 137
            .|.:..:.| |.|..|.:...|...:..| |:.|:|        |...|     ::.|:....|:
Worm   166 CLPHIVYWI-FEFQWTEIREYGIWEIPSGCANFTYTSPRIIYSMGPEEY-----QNETLLLVEGI 224

  Fly   138 FWALLQCSMFIGNLFVYYQFQDKTRIDKETRNLVIGVLTVIAVLGIVFLAALRFMADNAEHDNEL 202
            |:.|:.                         ::::.::|::.   |.||..::  ...|.::|
Worm   225 FFTLIP-------------------------SIILPIVTIVL---IYFLKTMK--RSTASNNN-- 257

  Fly   203 EQKHTGCGQAIYALKSAGQLFLTKKMLLLSLAFFYTGLE----LSFFSGVFGSAIGFTTKIAETP 263
              .|......:.||.:...|..|   :.|.:.:.|...:    :|||..:|.....|.:.|..|
Worm   258 --NHNARSTKMVALVTVTFLLAT---VPLGITYLYQHTDFSFGISFFCSMFVIICEFVSLINGT- 316

  Fly   264 KEIVGLVGICIGA------GEVFG 281
              :..|:.:||.:      .|:||
Worm   317 --MHFLLCVCISSQYQRIVREMFG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18549	NP_650203.3	MFS_MFSD11	8..423	CDD:340965	58/284 (20%)
srw-59	NP_506996.1	7TM_GPCR_Srw	31..340	CDD:370978	58/284 (20%)
		TM helix 1	34..53	CDD:320109
		TM helix 2	62..84	CDD:320109
		TM helix 3	113..135	CDD:320109	4/29 (14%)
		TM helix 4	160..176	CDD:320109	3/16 (19%)
		TM helix 5	216..239	CDD:320109	4/47 (9%)
		TM helix 6	261..286	CDD:320109	5/27 (19%)
		TM helix 7	301..326	CDD:320109	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3098
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900