DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sccpdh2 and SCCPDH

DIOPT Version :9

Sequence 1:	NP_650190.1	Gene:	Sccpdh2 / 41521	FlyBaseID:	FBgn0038038	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_057086.2	Gene:	SCCPDH / 51097	HGNCID:	24275	Length:	429	Species:	Homo sapiens

Alignment Length:	433	Identity:	166/433 - (38%)
Similarity:	259/433 - (59%)	Gaps:	28/433 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIFGASGFTGKYTVFEAV------SVLKGLQWGIAGRNQEKLQSVLREMGAK--SKTDLSQTPIV 65
            ::||||||||::...|..      .....|.|.:|||::||||.||.:...|  ..|..|:..|:
Human    11 VVFGASGFTGQFVTEEVAREQVDPERSSRLPWAVAGRSREKLQRVLEKAALKLGRPTLSSEVGII 75

  Fly    66 IADVNNEASLLEMAKRCRILVNTAGPYRFFGERVVRACIEAGTHHVDVSGEPQYMETMQLRYHDL 130
            |.|:.|.|||.||||:..:::|..|||||:||.|::||||.|...:|:|||||::|.|||:||:.
Human    76 ICDIANPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEK 140

  Fly   131 AKERGVYVISACGFDSIPADMGVTFVEKNFDGVVNSVENF--VHLGVKGGTKGTGSAALNTGTWE 193
            |.::|||:|.:.||||||||:||.:.....:|.:.:||:|  :|.|.:|       .:::.|||:
Human   141 AADKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLTIHSGPEG-------LSIHDGTWK 198

  Fly   194 SAIHAIANRSESVAIRRKLFPERLPNFHPALKSRSPLSRAAEVDNKVILPFPETDRSVVMRSQRF 258
            |||:...::|....:|.....:.:|...|.||.|.|:|...|:....| ||..:|.|||.|:||:
Human   199 SAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSI-PFMGSDVSVVRRTQRY 262

  Fly   259 LYELEKKRPVQMQAYMTYPSWFAASVVVLFASIIGI-MAKFSFGRQLLLKYPTVFSGGMASREGP 322
            |||..::.|||..||:|. ....:.:.::||.:..: ..:|..|||||:|:|..||.|..|::||
Human   263 LYENLEESPVQYAAYVTV-GGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGP 326

  Fly   323 SEARMERSFFRMTMKATGWPKSEKLAETTDQYTSPPTKTLTVRVTGPNPGYGSTCVALLSTAKTI 387
            ::.:::.:.|.:|....|:      ::.|....:.|...:..:|.||..||.:|.:|::..|.|:
Human   327 TQKQIDAASFTLTFFGQGY------SQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTL 385

  Fly   388 LNESDKMPGSGGVLPPGAAFRGTSLISELEKHEHGIKFEIVAN 430
            |:::..:|.:|||..|||||..|.||..|.|  |||:|.::::
Human   386 LSDASHLPKAGGVFTPGAAFSKTKLIDRLNK--HGIEFSVISS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sccpdh2	NP_650190.1	COG3268	7..416	CDD:225807	160/417 (38%)
Sccpdh2	NP_650190.1	Sacchrp_dh_NADP	9..139	CDD:281434	64/137 (47%)
SCCPDH	NP_057086.2	COG3268	1..421	CDD:225807	165/426 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155287
Domainoid	1	1.000	176	1.000	Domainoid score	I3623
eggNOG	1	0.900	-	-		E1_COG3268
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9334
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2701
Isobase	1	0.950	-	0	Normalized mean entropy	S4069
OMA	1	1.010	-	-		QHG56565
OrthoDB	1	1.010	-	-		D302978at33208
OrthoFinder	1	1.000	-	-		FOG0002586
OrthoInspector	1	1.000	-	-		otm41518
orthoMCL	1	0.900	-	-		OOG6_101495
Panther	1	1.100	-	-	O	PTHR12286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4081
SonicParanoid	1	1.000	-	-		X1697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750