DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and LIG6

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_176845.2	Gene:	LIG6 / 842991	AraportID:	AT1G66730	Length:	1396	Species:	Arabidopsis thaliana

Alignment Length:	674	Identity:	176/674 - (26%)
Similarity:	278/674 - (41%)	Gaps:	168/674 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LQRFFEKGSSGKG-----------FKGDTVLWVQFLIPAANQRVYNLQNK--------------- 94
            |.|.|....|.||           |:....|..:.::||    ||...||
plant   770 LVRTFASVESEKGKIKAMSMLCNMFRSLFALSPEDVLPA----VYLCTNKIAADHENIELNIGGS 830

  Fly    95 ---ALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLYLQEVEEMLLHLV 156
               :.::....|..:..:.|:..|...|||::..|:   ..|.|.|  ...|.:::|...|..:.
plant   831 LISSALEEACGISRSTVRDMYNSLGDLGDVAQLCRQ---TQKLLVP--PPPLLVRDVFSTLRKIS 890

  Fly   157 ERTKEDE---QTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQSSRDL 218
            .:|....   :.:|:.||.....:.:::..:|.:..:|||.|..|.:|.|.|            .
plant   891 VQTGTGSTRLKKNLIVKLMRSCREKEIKFLVRTLARNLRIGAMLRTVLPALG------------R 943

  Fly   219 VAIVEQFATKENKNYASSPVKKTKKTSSSA----------------------IQVMT-------- 253
            ..::..|....||..:.|..::..:..|:|                      |:..|
plant   944 AIVMNSFWNDHNKELSESCFREKLEGVSAAVVEAYNILPSLDVVVPSLMDKDIEFSTSTLSMVPG 1008

  Fly   254 -PISPMLASPCKSVEDAFKKSPTGLYS-EIKYDGERVQIHK-QGNDFKFFSRN-------LKPVV 308
             ||.||||...|.|::.|..|....:: |.||||:|.|||| .......||||       ...:|
plant  1009 IPIKPMLAKIAKGVQEFFNLSQEKAFTCEYKYDGQRAQIHKLLDGTVCIFSRNGDETTSRFPDLV 1073

  Fly   309 DHKIRALKKYIPQAFPGGGEMILDSEIILVDTDTG-ALLPFGSLGAHKKQT--------FANAAV 364
            |    .:|::   :.|.....:||:|::..|...| .|:.|..|...::.:        .....|
plant  1074 D----VIKQF---SCPAAETFMLDAEVVATDRINGNKLMSFQELSTRERGSKDALITTESIKVEV 1131

  Fly   365 CLFVFDCILYDGEDLTQLPFRKRREILEQ--------NIQPIKSHVQLSESEFLK---TTRELAA 418
            |:||||.:..:||.|..||.|:||..|::        .::..|.....:|...|.   |...:.|
plant  1132 CVFVFDIMFVNGEQLLALPLRERRRRLKEVFPETRPGYLEYAKEITVGAEEASLNNHDTLSRINA 1196

  Fly   419 MTARVLHANLEGVVLKS--PTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKG 479
            .......::.||:::||  ..:.|.|.||  :|||||:||: || :.||.|||.:|||||:|:|.
plant  1197 FLEEAFQSSCEGIMVKSLDVNAGYCPTKRSDSWLKVKRDYV-DG-LGDTLDLVPIGAWYGNGRKA 1259

  Fly   480 GTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPD 544
            |..|.|||.|::.....:::|.:|.||..||...|:.:...:                     ..
plant  1260 GWYSPFLMACFNPETEEFQSVCRVMSGFSDAFYIEMKEFYSE---------------------DK 1303

  Fly   545 VLAKDPM-----KMP--------VWEITGAEFTKSDAHTAS--------GISVRFPRITRRRSDK 588
            :|||.|.     :.|        ||||.||:||.|..|:||        ||||||||...:.:|:
plant  1304 ILAKKPPYYRTGETPDMWFSAEVVWEIRGADFTVSPVHSASLGLVHPSRGISVRFPRFISKVTDR 1368

  Fly   589 SAKEANDLAHLEDLFEASKSNVNV 612
            :.:|.:....:.::|.|....:|:
plant  1369 NPEECSTATDIAEMFHAQTRKMNI 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	37/175 (21%)
		dnl1	88..604	CDD:273147	163/621 (26%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	73/275 (27%)
		OBF_DNA_ligase_III	460..598	CDD:153436	52/158 (33%)
LIG6	NP_176845.2	SNM1A-1C-like_MBL-fold	42..204	CDD:293831
		DRMBL	276..380	CDD:284854
		PRK01109	766..1389	CDD:234900	175/669 (26%)
		DNA_ligase_A_N	766..937	CDD:282522	37/175 (21%)
		Adenylation_DNA_ligase_I_Euk	1002..1236	CDD:185710	69/240 (29%)
		OBF_DNA_ligase_I	1241..1385	CDD:153438	53/164 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920