DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and ATLIG4

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_568851.2	Gene:	ATLIG4 / 835822	AraportID:	AT5G57160	Length:	1219	Species:	Arabidopsis thaliana

Alignment Length:	714	Identity:	180/714 - (25%)
Similarity:	292/714 - (40%)	Gaps:	164/714 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 LYLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPD 207
            |.::|:.::|..|.......|:|.:|..|..|....:::..||::..||::....:.|...|.||
plant   125 LTIKELNDLLDRLASSENRAEKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSEKSIFQEFHPD 189

  Fly   208 AYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLASPCKSVEDAFKK 272
            |...:..:.||..:.|:...:..::            ....|:|...:.|.||.....|..|:||
plant   190 AEDLFNVTCDLKLVCEKLRDRHQRH------------KRQDIEVGKAVRPQLAMRIGDVNAAWKK 242

  Fly   273 -SPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDHK--IRALKKYIPQAFPGGGEMILDSE 334
             ....:.:|.|:||:|:||||.|.|..:||||.   :||.  ..|:...|.|... ..:.|||.|
plant   243 LHGKDVVAECKFDGDRIQIHKNGTDIHYFSRNF---LDHSEYAHAMSDLIVQNIL-VDKCILDGE 303

  Fly   335 IILVDTDTGALLPFGSLGAHKKQTFANAA---------VCLFVFDCILYDGE-DLTQLPFRKRRE 389
            :::.||.......|||     .|..|.||         :|...|| :||.|: .:.....::|.|
plant   304 MLVWDTSLNRFAEFGS-----NQEIAKAAREGLDSHKQLCYVAFD-VLYVGDTSVIHQSLKERHE 362

  Fly   390 ILEQNIQPIKSHVQL----------------SESEFLKTTRELAAMTARVLHANLEGVVLKSPTS 438
            :|::.::|:|..:::                |.|..:....::.......:....||:|||...|
plant   363 LLKKVVKPLKGRLEVLVPEGGLNVHRPSGEPSWSIVVHAAADVERFFKETVENRDEGIVLKDLES 427

  Fly   439 TYQPGKRN--WLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLMGCYD-----AFGRL 496
            .::||.|:  |:|:|.:|:..|  || .|::::|.:||||::||.::.||:...|     .:.|.
plant   428 KWEPGDRSGKWMKLKPEYIRAG--AD-LDVLIIGGYYGSGRRGGEVAQFLVALADRAEANVYPRR 489

  Fly   497 WKTVTKVHSGL-DDATNAEVHKSLIKLTERADAN---AIPSWLLC---SKSLVPDVLAKDPMKMP 554
            :.:..:|.:|| ||..|..|.|  :|...|.:.:   |.||:...   ||.. |||....|.|..
plant   490 FMSFCRVGTGLSDDELNTVVSK--LKPYFRKNEHPKKAPPSFYQVTNHSKER-PDVWIDSPEKSI 551

  Fly   555 VWEITGAEFTKSDAHT------ASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVNVD 613
            :..||      ||..|      .:..|:|||||.:.|.||...|..|:....:|..:|
plant   552 ILSIT------SDIRTIRSEVFVAPYSLRFPRIDKVRYDKPWHECLDVQAFVELVNSS------- 603

  Fly   614 LLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIRSLS 678
                          |.|| :|:|:....|.|  .|:.:|             |||.|.|.: ||.
plant   604 --------------NGTT-QKQKESESTQDN--PKVNKS-------------SKRGEKKNV-SLV 637

  Fly   679 PSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHFAMEKDSSKL---MQQFS 740
            |||     |.                 :.::.....|..:|..::.:|.....|..|   .:...
plant   638 PSQ-----FI-----------------QTDVSDIKGKTSIFSNMIFYFVNVPRSHSLETFHKMVV 680

  Fly   741 QHGGCCTTEPQKADLVFYANTNEA----LDLEKLRTLYRRSCRHLNV---SWLQSCLDTQSRQP 797
            ::||           .|..|.|.:    :..|.....|:.:.|..:|   ||:..|.......|
plant   681 ENGG-----------KFSMNLNNSVTHCIAAESSGIKYQAAKRQRDVIHFSWVLDCCSRNKMLP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	13/56 (23%)
		dnl1	88..604	CDD:273147	141/509 (28%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	67/242 (28%)
		OBF_DNA_ligase_III	460..598	CDD:153436	50/155 (32%)
ATLIG4	NP_568851.2	dnl1	61..600	CDD:273147	140/508 (28%)
		BRCT_DNA_ligase_IV_rpt1	655..741	CDD:349354	17/90 (19%)
		BRCT_DNA_ligase_IV_rpt2	802..898	CDD:349349
		PTZ00121	<909..>1180	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820