Protein Alignment: DNAlig3 and LIG3

• Sequence 1: NP_650187.2
• Gene: DNAlig3
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_005258027.1
• Gene: LIG3
• HGNCID: 6600
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 776
• Identity: 334/777 (43%)
• Similarity: 454/777 (58%)
• Gaps: 46/777 (6%)

  Fly    28 NEDNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQFLIPAANQRVYNLQ 92
            ::|..|..||::|..:|...||..|.:.:|.|..|||:|.||.||..|.|:.|:|...:.||||.
Human   267 HKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLN 331

  Fly    93 NKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLYLQEVEEMLLHLVE 157
            :|.::||||||||.:...|..|||| ||||||:|..|..||...|..:|.|.:|||:|.||.|.:
Human   332 DKQIVKLFSRIFNCNPDDMARDLEQ-GDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSK 395

  Fly   158 RTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQSSRDLVAIV 222
            .||||||...||.:.|:.|..||:..|||:||||::|:.|:|:|||..|:||.|:::||:|..:|
Human   396 LTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVV 460

  Fly   223 EQFATKENKNYASSPVKK---TKKTSSSAIQVMTPISPMLASPCKSVEDAFKKSPTGLYSEIKYD 284
            |:..      :.:..|:|   .::..|....:|||:.||||..|||||.|.||.|.|::||||||
Human   461 ERVL------HNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYD 519

  Fly   285 GERVQIHKQGNDFKFFSRNLKPVVDHKIRALKKYIPQAFPGGGEMILDSEIILVDTDTGALLPFG 349
            |||||:||.|:.|.:|||:||||:.||:...|.|||||||||..||||||::|:|..||..||||
Human   520 GERVQVHKNGDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKPLPFG 584

  Fly   350 SLGAHKKQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTR 414
            :||.|||..|.:|.|||||||||.::...|...|..:||:.|..|:..|.:.:..||.:.:....
Human   585 TLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKAL 649

  Fly   415 ELAAMTARVLHANLEGVVLKSPTSTYQPGKRNWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKG 479
            :||.|..||:...|||:|||....||:||||:|||||||||.:|.||||||||||||:||.|.||
Human   650 DLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG 714

  Fly   480 GTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPD 544
            |.:|||||||||...:.|.||||...|.||||.|.:...|..:....|.:.|||||..:|...||
Human   715 GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPD 779

  Fly   545 VLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSN 609
            .:..||.|..|||||||||:||:||||.|||:||||.||.|.||..|.|.:|..|::|::.||..
Human   780 FIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEK 844

  Fly   610 VNVDLLLANCSKDETAMNNKTTPEKEKKLNGN---------QSNGSKKLKRSNTGSDDEDGAPVL 665
            .:..::    :.||.:.....:.|:.|..:|:         .|..:||.:...:.|:.:||....
Human   845 ADFTVV----AGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQT 905

  Fly   666 SKRKESKAIRSLSPSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHF-AME 729
            :|....|....|:.....:|           |.:|....|| .:..|.....:|.|:..:. ...
Human   906 AKPSAMKVGEKLATKSSPVK-----------VGEKRKAADE-TLCQTKVLLDIFTGVRLYLPPST 958

  Fly   730 KDSSKLMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRHLNVSWLQSCL 790
            .|.|:|.:.|....|         |||...:...|..:...|. ...:.:.::..|:.:|:
Human   959 PDFSRLRRYFVAFDG---------DLVQEFDMTSATHVLGSRD-KNPAAQQVSPEWIWACI 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	81/164 (49%)
		dnl1	88..604	CDD:273147	275/519 (53%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	115/212 (54%)
		OBF_DNA_ligase_III	460..598	CDD:153436	81/138 (59%)
LIG3	XP_005258027.1	zf-PARP	106..188	CDD:279039
		DNA_ligase_A_N	273..438	CDD:282522	81/166 (49%)
		dnl1	327..839	CDD:273147	275/519 (53%)
		Adenylation_DNA_ligase_III	477..689	CDD:185712	115/212 (54%)
		OBF_DNA_ligase_III	695..833	CDD:153436	81/138 (59%)
		LIG3_BRCT	942..1013	CDD:293364	14/79 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C322368381
eggNOG	1	0.900				E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H32109
Inparanoid	1	1.050	584	1.000	Inparanoid score	I998
Isobase	1	0.950		0	Normalized mean entropy	S3614
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D189866at33208
OrthoFinder	1	1.000				FOG0007850
OrthoInspector	1	1.000				T1074063
orthoMCL	1	0.900				OOG5_134498
Panther	1	1.100			LDO	PTHR45674
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3850
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	13	12.740