DRSC/TRiP Functional Genomics Resources

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Protein Alignment: DNAlig3 and LIG1

Sequence 1:NP_650187.2 Gene:DNAlig3 FlyBaseID:FBgn0286075 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_000225.1 Gene:LIG1 HGNCID:6598 Length:919 Species:Homo sapiens

Alignment Length:439 Identity:130/440 (30%)
Similarity:195/440 (44%) Gaps:92/440 (21%)


  Fly   254 PISPMLASPCKSVEDAFKKSPTGLYS-EIKYDGERVQIHK-QGNDFKFFSRNLK------PVVDH 310
            |:.||||.|.:.:.:..|:.....:: |.||||:|.|||. :|.:.|.||||.:      |.:..
Human   539 PLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIIS 603

  Fly   311 KIRALKKYIPQAFPGGGEMILDSEIILVDTDTGALLPFGSLGAHKKQ----TFANAAVCLFVFDC 371
            :|..:|      .|.....|||:|.:..|.:...:.||..|...|::    :.....|||:.||.
Human   604 RIPKIK------LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDL 662

  Fly   372 ILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKS- 435
            |..:||.|.:.|..:||::|.:|....:.....:.|...|...::|....:.:..:.||:::|: 
Human   663 IYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTL 727

  Fly   436 -PTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRLW 497
             ..:||:..||  ||||:||||| || :.||.||||:||:.|.||:.|....||:..||......
Human   728 DVDATYEIAKRSHNWLKLKKDYL-DG-VGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEEL 790

  Fly   498 KTVTKVHSGLDDATNAEVHKSLIKLT-------ERADANAIPS-WLLCSKSLVPDVLAKDPMKMP 554
            :.:.|:.:|..|....|.|:||..|.       .|.|...||. ||             ||  ..
Human   791 QAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWL-------------DP--SA 840

  Fly   555 VWEITGAEFTKSDAHTAS--------GISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVN 611
            |||:..|:.:.|..:.|:        |||:||||..|.|.||..::|...|.:..|:        
Human   841 VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLY-------- 897

  Fly   612 VDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDED 660
                                 .|:.::...|...|        |||.||
Human   898 ---------------------RKQSQIQNQQGEDS--------GSDPED 917

Known Domains:


GeneSequenceDomainRegion External IDIdentity
DNAlig3NP_650187.2 DNA_ligase_A_N 36..200 CDD:282522
dnl1 88..604 CDD:273147 122/382 (32%)
Adenylation_DNA_ligase_III 242..454 CDD:185712 66/216 (31%)
OBF_DNA_ligase_III 460..598 CDD:153436 51/154 (33%)
LIG1NP_000225.1 DUF4045 <10..275 CDD:330572
CDC9 164..914 CDD:330238 127/435 (29%)
Interaction with target DNA 449..458
Interaction with target DNA 642..644 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_COG1793
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 D274264at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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