DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and Lig4

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001363971.1	Gene:	Lig4 / 319583	MGIID:	1335098	Length:	911	Species:	Mus musculus

Alignment Length:	857	Identity:	195/857 - (22%)
Similarity:	327/857 - (38%)	Gaps:	218/857 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQF--------------------- 79
            |..:|..:          ||:|:..::....:.||.....|.:|
Mouse    16 FADLCSTL----------ERIQKGKDRAEKIRHFKEFLDSWRKFHDALHKNRKDVTDSFYPAMRL 70

  Fly    80 LIPAANQR--VYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKH------------FA 130
            ::|...:.  .|.::...|.||:..:.|         |.::|..::.|..:            ||
Mouse    71 ILPQLERERMAYGIKETMLAKLYIELLN---------LPREGKDAQKLLNYRTPSGARTDAGDFA 126

  Fly   131 --ASKKLKPQ--KQSKLYLQEVEEMLLHLVERTKEDEQTDLLQK----LCSKATDLDLRTFIRLV 187
              |...|||:  ::..|.:|:|.| ||.||......::.||::|    |.::::.|:.:..||::
Mouse   127 MIAYFVLKPRCLQKGSLTIQQVNE-LLDLVASNNSGKKKDLVKKSLLQLITQSSALEQKWLIRMI 190

  Fly   188 KHDLRINARARHILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVM 252
            ..||::....:.|...|..||...:..:.||..:..|.         ..|   :...|..:|.:.
Mouse   191 IKDLKLGISQQTIFSIFHNDAVELHNVTTDLEKVCRQL---------HDP---SVGLSDISITLF 243

  Fly   253 TPISPMLA--SPCKSVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDH----- 310
            :...||||  :..:.||...|:.  ..|.|.|.||||:|:||.|..:::||||.....|.
Mouse   244 SAFKPMLAAVADVERVEKDMKQQ--SFYIETKLDGERMQMHKDGALYRYFSRNGYNYTDQFGESP 306

  Fly   311 KIRALKKYIPQAFPGGGEM---ILDSEIILVDTDTGALLPFGSLGAHKKQTFANAAV-------- 364
            :..:|..:|..||  |.::   |||.|::..:..|              |||....|
Mouse   307 QEGSLTPFIHNAF--GTDVQACILDGEMMAYNPTT--------------QTFMQKGVKFDIKRMV 355

  Fly   365 -------CLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTAR 422
                   |..|||.::.:.:.|.:...|||.|||.....||:..:::.:.....|.:|:......
Mouse   356 EDSGLQTCYSVFDVLMVNKKKLGRETLRKRYEILSSTFTPIQGRIEIVQKTQAHTKKEVVDALND 420

  Fly   423 VLHANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIF 485
            .:....||:::|.|.|.|:|.||  .|||:|.:|: .|.| |..|::::|.::|.|.:||.:|.|
Mouse   421 AIDKREEGIMVKHPLSIYKPDKRGEGWLKIKPEYV-SGLM-DELDVLIVGGYWGKGSRGGMMSHF 483

  Fly   486 LMGCYDA-----FGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPDV 545
            |....:.     ...::.|:.:|.||.......::...|.|..:.....:.||.:||... .|:|
Mouse   484 LCAVAETPPPGDRPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFHKKSPPSSILCGTE-KPEV 547

  Fly   546 LAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNV 610
            .. :|....:.:|..||...||.: .:|.::|||||.:.|.||...|...|..||.|
Mouse   548 YI-EPQNSVIVQIKAAEIVPSDMY-KTGSTLRFPRIEKIRDDKEWHECMTLGDLEQL-------- 602

  Fly   611 NVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIR 675
                                         ..:::|....|..:.|.|||
Mouse   603 -----------------------------RGKASGKLATKHLHVGDDDE---------------- 622

  Fly   676 SLSPSQKGLKDFFKPSKEFKSVVK-KEPKEDEGNIESTSSKPQLFE--------GLVAHFAMEKD 731
               |.:|..|...|..|..:.:.. |.|     |:.:.:....:||        ||..:     .
Mouse   623 ---PREKRRKPISKTKKAIRIIEHLKAP-----NLSNVNKVSNVFEDVEFCVMSGLDGY-----P 674

  Fly   732 SSKLMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRHLNV---SWLQSCLDTQ 793
            .:.|..:.::.||.....|........|.:      |.:|.....|....:|   .||..|..|:
Mouse   675 KADLENRIAEFGGYIVQNPGPDTYCVIAGS------ENVRVKNIISSDKNDVVKPEWLLECFKTK 733

  Fly   794 SRQP----FPLH 801
            :..|    |.:|
Mouse   734 TCVPWQPRFMIH 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	41/206 (20%)
		dnl1	88..604	CDD:273147	151/567 (27%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	67/238 (28%)
		OBF_DNA_ligase_III	460..598	CDD:153436	40/142 (28%)
Lig4	NP_001363971.1	dnl1	81..602	CDD:273147	150/565 (27%)
		BRCT_DNA_ligase_IV_rpt1	658..745	CDD:349354	19/97 (20%)
		DNA_ligase_IV	750..782	CDD:371515
		BRCT_DNA_ligase_IV_rpt2	813..900	CDD:349349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820