DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and Lig3

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001380964.1	Gene:	Lig3 / 303369	RGDID:	1309875	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	337/790 - (42%)
Similarity:	460/790 - (58%)	Gaps:	58/790 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TRLLCNKMASKGLHNEDNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQ 78
            |.|..:|...|   ::|..|..||::|..:|...||..|.:.:..|.:|||:|.||:||..|.|:
  Rat   249 TSLSASKCDPK---HKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGDGFRGDVYLTVK 310

  Fly    79 FLIPAANQRVYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKL 143
            .|:|...:.||||.:|.::||||||||.:...|..|||| ||||||:|..|..||...|..:|.|
  Rat   311 LLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQ-GDVSETIRVFFEQSKSFPPAAKSLL 374

  Fly   144 YLQEVEEMLLHLVERTKEDEQTDLLQKLCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDA 208
            .:|||:..||||.:.||||||...||.:.|:.|..||:..|||:||||::|:.|:|:|||..|:|
  Rat   375 TIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNA 439

  Fly   209 YPAYQSSRDLVAIVEQFATKENKNYASSPVKK---TKKTSSSAIQVMTPISPMLASPCKSVEDAF 270
            |.|:::||:|..:||:....|.:      |:|   .::..|....:|||:.||||..|||:|.|.
  Rat   440 YEAFKASRNLQDVVERVLHNEQE------VEKDPGRRRALSVQASLMTPVQPMLAEACKSIEYAM 498

  Fly   271 KKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDHKIRALKKYIPQAFPGGGEMILDSEI 335
            ||.|.|::|||||||||||:||:|:.|.:|||:||||:.||:...|.|||:|||||..||||||:
  Rat   499 KKCPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEV 563

  Fly   336 ILVDTDTGALLPFGSLGAHKKQTFANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKS 400
            :|:|.:||..||||:||.|||..|.:|.|||||||||.::...|...|..:||:.|..|:..|::
  Rat   564 LLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRN 628

  Fly   401 HVQLSESEFLKTTRELAAMTARVLHANLEGVVLKSPTSTYQPGKRNWLKVKKDYLFDGKMADTAD 465
            .:..||.:.:....:||.|..||:...|||:|||....||:||||:|||||||||.:|.||||||
  Rat   629 RIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTAD 693

  Fly   466 LVVLGAWYGSGKKGGTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANA 530
            ||||||:||.|.|||.:|||||||||...:.|.||||...|.||||.|.:.|.|..:....|.:.
  Rat   694 LVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELDMVKISKDPSK 758

  Fly   531 IPSWLLCSKSLVPDVLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEAND 595
            |||||..:|...||.:..||.|..|||||||||::|:||||.|||:||||.||.|.||..|.|.:
  Rat   759 IPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATN 823

  Fly   596 LAHLEDLFEASKSNVNVDLLLANCSKDETAMNN--------KTTPEKEKKLNGNQSNGSKKLKRS 652
            |..|::|::.||...:..::..:.....|..:|        .|.|.|..|  |..|..|...|::
  Rat   824 LPQLKELYQLSKDKADFAVVAGDEGSSTTGGSNGENEGTAGSTVPRKGPK--GPPSKSSASAKKT 886

  Fly   653 NTGSDDEDGAPVLSKRKESKAIRSLSPSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQ 717
            ....:|..     |:..|..|::| ||.:.|:|             :|...|..|   .|.:...
  Rat   887 EQKLNDPS-----SRGGEKLAVKS-SPVKVGMK-------------RKAADETPG---LTKALLD 929

  Fly   718 LFEGLVAHF-AMEKDSSKLMQQFSQHGGCCTTEPQKADLV-FYANTNEALDLEKLRTLYRRSCRH 780
            :|.|:..:. ....|..:|.:.|....|....|...|... ...|.::..|.:.:.:
  Rat   930 VFTGVRLYLPPSTPDFRRLKRYFVAFNGDLVQEFDMASATHVLGNRDKNTDAQLVSS-------- 986

  Fly   781 LNVSWLQSCL 790
               .|:.:|:
  Rat   987 ---EWIWACI 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	79/163 (48%)
		dnl1	88..604	CDD:273147	274/518 (53%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	112/211 (53%)
		OBF_DNA_ligase_III	460..598	CDD:153436	81/137 (59%)
Lig3	NP_001380964.1	zf-PARP	97..182	CDD:395520
		dnl1	320..832	CDD:273147	274/518 (53%)
		LIG3_BRCT	927..997	CDD:407027	12/78 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353075
Domainoid	1	1.000	227	1.000	Domainoid score	I2424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32109
Inparanoid	1	1.050	588	1.000	Inparanoid score	I961
OMA	1	1.010	-	-		QHG52366
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	1	1.000	-	-		FOG0009220
OrthoInspector	1	1.000	-	-		oto98799
orthoMCL	1	0.900	-	-		OOG6_106861
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6002
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910