Protein Alignment DNAlig3 and Lig4

DIOPT Version :10

• Sequence 1: NP_650187.2
• Gene: DNAlig3 / 41518
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001099565.1
• Gene: Lig4 / 290907
• RGDID: 1304639
• Length: 911
• Species: Rattus norvegicus
• Alignment Length: 853
• Identity: 197/853 - (23%)
• Similarity: 333/853 - (39%)
• Gaps: 210/853 - (24%)

  Fly    36 FRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQF--------------------- 79
            |..:|..:          ||:|:..::....:.||.....|.:|
  Rat    16 FADLCSTL----------ERIQKGKDRAEKIRHFKEFLDSWRKFHDALHKNKKDVPDSFYPAMRL 70

  Fly    80 LIPAANQR--VYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKH------------FA 130
            ::|...:.  .|.::...|.||:..:.|         |.::|..::.|..:            ||
  Rat    71 ILPQLERERMAYGIKETMLAKLYIELLN---------LPREGKDAQKLLNYRTPSGARSDAGDFA 126

  Fly   131 --ASKKLKPQ--KQSKLYLQEVEEMLLHLVERTKEDEQTDLLQK----LCSKATDLDLRTFIRLV 187
              |...|||:  ::..|.:|:|.| ||.||......::.||::|    |.::.:.|:.:..||::
  Rat   127 TIAYFVLKPRCLQKGSLTIQKVNE-LLDLVASNNSGKRKDLVKKSLLQLITQCSALEQKWLIRMI 190

  Fly   188 KHDLRINARARHILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVM 252
            ..||::......||..|..||...:..:.||..:..|.         ..|   :...|..:|.:.
  Rat   191 IKDLKLGVSQHTILSIFHNDAVELHNVTTDLEKVCRQL---------HDP---SVGLSDISITLF 243

  Fly   253 TPISPMLA--SPCKSVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDH----- 310
            :...||||  :..:.||...|:.  ..|.|.|.||||:|:||.|..:::||||.....|.
  Rat   244 SAFRPMLAAVADVERVEKDMKQQ--SFYIETKLDGERMQMHKDGALYRYFSRNGYNYTDQFGESP 306

  Fly   311 KIRALKKYIPQAFPGGGEM-ILDSEIILVDTDTGALLPFGSLGAHKKQTFANAAV---------- 364
            :..:|..:|..||....:: |||.|::..:..|              |||....|
  Rat   307 QEGSLTPFIHNAFKTDVQVCILDGEMMAYNPTT--------------QTFMQKGVKFDIKRMVED 357

  Fly   365 -----CLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTARVL 424
                 |..|||.::.:.:.|.:...|||.:||.....||:..:::.:....:|.:|:.......:
  Rat   358 SDLQTCYCVFDVLMVNNKKLGRETLRKRYDILSSTFTPIQGRIEIVQKTQAQTKQEVVDALNDAI 422

  Fly   425 HANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLM 487
            ....||:::|.|.|.|:|.||  .|||:|.:|: .|.| |..||:::|.::|.|.:||.:|.||.
  Rat   423 DKREEGIMVKHPLSIYKPDKRGEGWLKIKPEYV-TGLM-DELDLLIVGGYWGKGSRGGMMSHFLC 485

  Fly   488 GCYDA-----FGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPDVLA 547
            ...:.     ...::.|:.:|.||.......::...|.|..:.....:.||.:||... .|:|..
  Rat   486 AVAETPPPGDKPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFQRKSPPSCILCGTE-KPEVYI 549

  Fly   548 KDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVNV 612
             :|....:.:|..||...||.: .:|.::|||||.:.|.|   ||.:|...|:||
  Rat   550 -EPQNSVIVQIKAAEIVPSDMY-KTGSTLRFPRIEKIRDD---KEWHDCMTLDDL---------- 599

  Fly   613 DLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIRSL 677
                                   ::|.| :::|....|..:.|.|||
  Rat   600 -----------------------EQLRG-KASGKLATKHLHIGDDDE------------------ 622

  Fly   678 SPSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFE--------GLVAHFAMEKDSSK 734
             |.:|..|...|..|.. .:::.....:..||...|:   :||        ||..:     ....
  Rat   623 -PREKRRKPISKTKKTI-GIIEHLKAPNLSNINKVSN---VFEDVEFCVMSGLDGY-----PKPD 677

  Fly   735 LMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRH--LNVSWLQSCLDTQSRQP 797
            |..:.::.||.....|........|.:...    ::|.:. .|.||  :...||..|..|::..|
  Rat   678 LENKIAEFGGYIVQNPGPDTYCVIAGSENI----RVRNII-SSDRHDVVKPEWLLECFKTKTCVP 737

  Fly   798 ----FPLH 801
                |.:|
  Rat   738 WQPRFMIH 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	dnl1	88..604	CDD:273147	151/565 (27%)
Lig4	NP_001099565.1	dnl1	81..602	CDD:273147	151/599 (25%)
		BRCT_DNA_ligase_IV_rpt1	658..745	CDD:349354	19/96 (20%)
		DNA_ligase_IV	750..782	CDD:463272
		BRCT_DNA_ligase_IV_rpt2	813..900	CDD:349349