DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig3 and Lig4

DIOPT Version :9

Sequence 1:	NP_650187.2	Gene:	DNAlig3 / 41518	FlyBaseID:	FBgn0286075	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001099565.1	Gene:	Lig4 / 290907	RGDID:	1304639	Length:	911	Species:	Rattus norvegicus

Alignment Length:	853	Identity:	197/853 - (23%)
Similarity:	333/853 - (39%)	Gaps:	210/853 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQF--------------------- 79
            |..:|..:          ||:|:..::....:.||.....|.:|
  Rat    16 FADLCSTL----------ERIQKGKDRAEKIRHFKEFLDSWRKFHDALHKNKKDVPDSFYPAMRL 70

  Fly    80 LIPAANQR--VYNLQNKALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKH------------FA 130
            ::|...:.  .|.::...|.||:..:.|         |.::|..::.|..:            ||
  Rat    71 ILPQLERERMAYGIKETMLAKLYIELLN---------LPREGKDAQKLLNYRTPSGARSDAGDFA 126

  Fly   131 --ASKKLKPQ--KQSKLYLQEVEEMLLHLVERTKEDEQTDLLQK----LCSKATDLDLRTFIRLV 187
              |...|||:  ::..|.:|:|.| ||.||......::.||::|    |.::.:.|:.:..||::
  Rat   127 TIAYFVLKPRCLQKGSLTIQKVNE-LLDLVASNNSGKRKDLVKKSLLQLITQCSALEQKWLIRMI 190

  Fly   188 KHDLRINARARHILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVM 252
            ..||::......||..|..||...:..:.||..:..|.         ..|   :...|..:|.:.
  Rat   191 IKDLKLGVSQHTILSIFHNDAVELHNVTTDLEKVCRQL---------HDP---SVGLSDISITLF 243

  Fly   253 TPISPMLA--SPCKSVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDH----- 310
            :...||||  :..:.||...|:.  ..|.|.|.||||:|:||.|..:::||||.....|.
  Rat   244 SAFRPMLAAVADVERVEKDMKQQ--SFYIETKLDGERMQMHKDGALYRYFSRNGYNYTDQFGESP 306

  Fly   311 KIRALKKYIPQAFPGGGEM-ILDSEIILVDTDTGALLPFGSLGAHKKQTFANAAV---------- 364
            :..:|..:|..||....:: |||.|::..:..|              |||....|
  Rat   307 QEGSLTPFIHNAFKTDVQVCILDGEMMAYNPTT--------------QTFMQKGVKFDIKRMVED 357

  Fly   365 -----CLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTARVL 424
                 |..|||.::.:.:.|.:...|||.:||.....||:..:::.:....:|.:|:.......:
  Rat   358 SDLQTCYCVFDVLMVNNKKLGRETLRKRYDILSSTFTPIQGRIEIVQKTQAQTKQEVVDALNDAI 422

  Fly   425 HANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLM 487
            ....||:::|.|.|.|:|.||  .|||:|.:|: .|.| |..||:::|.::|.|.:||.:|.||.
  Rat   423 DKREEGIMVKHPLSIYKPDKRGEGWLKIKPEYV-TGLM-DELDLLIVGGYWGKGSRGGMMSHFLC 485

  Fly   488 GCYDA-----FGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPDVLA 547
            ...:.     ...::.|:.:|.||.......::...|.|..:.....:.||.:||... .|:|..
  Rat   486 AVAETPPPGDKPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFQRKSPPSCILCGTE-KPEVYI 549

  Fly   548 KDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNVNV 612
             :|....:.:|..||...||.: .:|.::|||||.:.|.|   ||.:|...|:||
  Rat   550 -EPQNSVIVQIKAAEIVPSDMY-KTGSTLRFPRIEKIRDD---KEWHDCMTLDDL---------- 599

  Fly   613 DLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSKRKESKAIRSL 677
                                   ::|.| :::|....|..:.|.|||
  Rat   600 -----------------------EQLRG-KASGKLATKHLHIGDDDE------------------ 622

  Fly   678 SPSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFE--------GLVAHFAMEKDSSK 734
             |.:|..|...|..|.. .:::.....:..||...|:   :||        ||..:     ....
  Rat   623 -PREKRRKPISKTKKTI-GIIEHLKAPNLSNINKVSN---VFEDVEFCVMSGLDGY-----PKPD 677

  Fly   735 LMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRH--LNVSWLQSCLDTQSRQP 797
            |..:.::.||.....|........|.:...    ::|.:. .|.||  :...||..|..|::..|
  Rat   678 LENKIAEFGGYIVQNPGPDTYCVIAGSENI----RVRNII-SSDRHDVVKPEWLLECFKTKTCVP 737

  Fly   798 ----FPLH 801
                |.:|
  Rat   738 WQPRFMIH 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	DNA_ligase_A_N	36..200	CDD:282522	41/206 (20%)
		dnl1	88..604	CDD:273147	151/565 (27%)
		Adenylation_DNA_ligase_III	242..454	CDD:185712	65/236 (28%)
		OBF_DNA_ligase_III	460..598	CDD:153436	41/142 (29%)
Lig4	NP_001099565.1	DNA_ligase_A_N	15..203	CDD:282522	41/206 (20%)
		dnl1	81..602	CDD:273147	151/599 (25%)
		Adenylation_DNA_ligase_IV	235..455	CDD:185713	65/235 (28%)
		OBF_DNA_ligase_IV	459..596	CDD:153437	41/143 (29%)
		BRCT	654..730	CDD:278934	16/88 (18%)
		DNA_ligase_IV	750..782	CDD:288294
		BRCT	<845..899	CDD:237994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189866at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820