Protein Alignment DNAlig3 and lig-4

DIOPT Version :10

• Sequence 1: NP_650187.2
• Gene: DNAlig3 / 41518
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001367462.1
• Gene: lig-4 / 176067
• WormBaseID: WBGene00002986
• Length: 741
• Species: Caenorhabditis elegans
• Alignment Length: 836
• Identity: 171/836 - (20%)
• Similarity: 299/836 - (35%)
• Gaps: 204/836 - (24%)

  Fly    30 DNKLDTFRRICDEIAGESSYLKKAERLQRFFEKGSSGKGFKGDTVLWVQFLIPAANQ-RVYNLQN 93
            |..:|.|    ::|...|:...|....|:.||..........|..:.::|.:....: |.:::..
 Worm     8 DEVVDVF----NKIRRTSNVKSKQATFQKNFESWKEKCSDPSDMFVIIRFFVSDYERFRKFDMGP 68

  Fly    94 KALIKLFSRIFNADQQQMHLDLEQDGDVSETLRKHFAASKKLKPQKQSKLY-----------LQE 147
            ..|....::.|:          :...|...|:.|..:.:.:...:|.|:.|           :.|
 Worm    69 TKLASFMAKTFH----------DVRADYVSTISKDASTAARQLAEKISEEYRTENDESTVVTVSE 123

  Fly   148 VEEMLLHLVERTKED-EQTDLLQKLCSKATDLDLRTFIRLVKHDLR--INARARHILDAFGPDAY 209
            :.|:|..|.....:| .:.|.:.||..:.::.:|.....::..::.  :.|.:..|||...|.|.
 Worm   124 LNEILDFLAAGPMDDGNKRDKMSKLVKRCSEDELEWIFNVILKNVESALGAPSNRILDWISPSAC 188

  Fly   210 PAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAI-QVMTPISPMLASPCK------SVE 267
            ..:..:.||.|:::   .|..:|..::.:.:|.......: ::.|   |||....|      ::|
 Worm   189 AIWDQTHDLKAVLK---GKLVENKGTNELGETNDDDDEHLFKIWT---PMLLQKQKRGDWYANIE 247

  Fly   268 DAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRN----LKPVVDHK--IRALKKYIPQAFPGG 326
               |......:.:.|:|||.|.:||:||::::|:||    .|...|..  |..|...|...|...
 Worm   248 ---KFGGQKFFLQTKFDGENVLLHKKGNEYRWFTRNNNDFSKEYGDSSMAIGKLSSRIHSFFNKE 309

  Fly   327 GE-MILDSEIILVDTDTGALLPFGSLGA----------HKKQTFANAAVCLFVFDCILYDGEDLT 380
            .| .|.:.|::|.|..|..|........          |.|.. .|..:.:.:||.:..:|:...
 Worm   310 CESAIFNCELMLWDKKTKKLCRHNDASTTSDAQVLSFRHVKPD-DNQQLTVVLFDLLYLNGKPFF 373

  Fly   381 QLPFRKRREILEQNIQPIK----------SHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKS 435
            ..|..:|.|:|:  |.|:|          .|.:.|:.|.::...|:|      :..|.||:|:|.
 Worm   374 GAPLHQRLEMLK--IAPLKKEREDTIFVAKHEEGSKKEDIQQFFEIA------MANNEEGIVVKR 430

  Fly   436 PTSTYQPGKRN----WLKVKKDYLFDGKMADTADLVVLGAWYGSGKKGGTLSIFLMGCYDAFGRL 496
            ..|.|..|:|:    |.|:|.....|..:    ||.::....|:|:.|.||  :....:|...:.
 Worm   431 TDSVYVKGQRSASNGWFKLKPSASKDCDL----DLALVAVHPGAGRNGKTL--YRFAAFDEKTQD 489

  Fly   497 WKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSKSLVPDVL---AKDP-------- 550
            :|.......||.|.....:.....:|.|.|                |:.|   .|.|
 Worm   490 YKLCLSCSYGLSDTVREAIRFEYGQLLEEA----------------PEELTFYGKRPKNIARGDG 538

  Fly   551 --MKMPVWEITGAEFTKSDAHTASGI---SVRFPRITRRRSDKSAKEANDLAHLEDLFEASKSNV 610
              :....|::...        |::|:   .:..|.:...|.||..::.|......|.
 Worm   539 GYIDFERWQVIKI--------TSNGVRNGKLVDPVMREWRLDKPVEQVNTWEEFSDY-------- 587

  Fly   611 NVDLLLANCSKDETAMNNKTTPEKEKKLNGNQSNGSKKLKRSNTGSDDEDGAPVLSK--RKESKA 673
                               .|..:|.||..|..:..:         |.||..|...|  |...||
 Worm   588 -------------------ATALQECKLGDNVDSDEE---------DSEDKKPDTLKVERITRKA 624

  Fly   674 IRSLSPSQKGLKDFFKPSKEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHFAME-----KDSS 733
            |...:|.:      .|.:|...|:...|....:|..|:...|   .|.::.||...     ..|:
 Worm   625 IHQSAPVR------LKRAKLESSLTGIEVAVLQGTSETIRRK---CEEILKHFDATVVKGITPST 680

  Fly   734 KLMQQFSQHGGCCTTEPQKADLVFYANTNEALDLEKLRTLYRRSCRHLNVSWLQSC 789
            ||         |..|.|:..    :..|.:|        :...||..|..:||:.|
 Worm   681 KL---------CIATAPKST----HPKTAQA--------IASNSCTVLKPAWLERC 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig3	NP_650187.2	dnl1	88..604	CDD:273147	120/583 (21%)
lig-4	NP_001367462.1	DNA_ligase_A_N	7..167	CDD:461387	29/172 (17%)
		Adenylation_DNA_ligase_IV	218..451	CDD:185713	61/247 (25%)
		OBF_DNA_ligase_family	459..582	CDD:447632	27/152 (18%)
		BRCT	644..731	CDD:469589	21/96 (22%)