DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34402 and TLL1

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_036596.3	Gene:	TLL1 / 7092	HGNCID:	11843	Length:	1013	Species:	Homo sapiens

Alignment Length:	765	Identity:	137/765 - (17%)
Similarity:	246/765 - (32%)	Gaps:	261/765 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SFTVSHWPLTM-PAASLALGLTVV------------------------LLATGNGQSQQAVTNSK 43
            |:|...|.::: |...:.|..|.:                        ||....|.....|..|.
Human   371 SYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTST 435

  Fly    44 QSHFWLDCSCLHLSERNATQW----------------------------------------GRLA 68
            .|..|::.       |:::.|                                        .::.
Human   436 DSRMWIEF-------RSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIT 493

  Fly    69 INASHSLGAKNNCLMIFIAGMDDELVAFQLEQLQLRAGCLDSVDIFPYL--REPVIENATLAADT 131
            ::.|:.:|                 :.||..:::....|     .:.||  |:...||:.|.. .
Human   494 VSESYHVG-----------------LTFQSFEIERHDNC-----AYDYLEVRDGTSENSPLIG-R 535

  Fly   132 FCQHSRERSATPIYSAGRLLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSF-- 194
            ||.:.:                       |.|:.|.:.||     ::|   |.:||.:....|
Human   536 FCGYDK-----------------------PEDIRSTSNTL-----WMK---FVSDGTVNKAGFAA 569

  Fly   195 ----------------CDFYFFASLSGEEANMGQGY-----------------------FHSPQF 220
                            |:.....:|...:.....||                       ..:|.:
Human   570 NFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGW 634

  Fly   221 PAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGG--CQLDALTLFDAESAHMNSVIDVICS 283
            |..||.:..|.::.:......:.:.||..:|    .|.  |:.|.:.::...|:. :.:....|.
Human   635 PKEYPPNKNCVWQVVAPTQYRISVKFEFFEL----EGNEVCKYDYVEIWSGLSSE-SKLHGKFCG 694

  Fly   284 SRPTRRLVSTGPDLLLEFNASSNRTAKGFRGKYKFVSNDLGVPNASVPPPAVLEAASVVVKQEKL 348
            :.....:.|...::.:||.:.:..:.|||:..: |...|
Human   695 AEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF-FSDKD-------------------------- 732

  Fly   349 QQEQASAAKENSLMSDVELSKPGRSFEQCKQTFDSRVNKSGIFDS--NQLLLAKHALGGVVIG-- 409
                 ..:|:|.......::..|....||:..|....||....::  .|.:   |:..|::..
Human   733 -----ECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKI---HSPSGLITSPN 789

  Fly   410 -----GSRVLQCRYEFEAQAPERVQIRFHDFNVPTEHENSTGCQPGDALHVV---TE---LRGRY 463
                 .|| .:|.:|..|....|:::.|.:|.:....|.:.     |.|.|.   ||   :.||
Human   790 WPDKYPSR-KECTWEISATPGHRIKLAFSEFEIEQHQECAY-----DHLEVFDGETEKSPILGR- 847

  Fly   464 ETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEGCS 528
                 |||..:|.||:::|.::.::||.      ...||..||:|.:.  |..|.....:.:...
Human   848 -----LCGNKIPDPLVATGNKMFVRFVS------DASVQRKGFQATHS--TECGGRLKAESKPRD 899

  Fly   529 FVYNSSERISGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTYFDIEGIGSCDHQTASDYIE 593
             :|:.::     |...|:||    .|.|.:........|:.|.|..|::|....|.:    ||:|
Human   900 -LYSHAQ-----FGDNNYPG----QVDCEWLLVSERGSRLELSFQTFEVEEEADCGY----DYVE 950

  Fly   594 -FSNFMSTDRKFSRYCGKLPDFEMRSDGRFFRVTLHSNDRFVAIGFRALY 642
             |....||.....|:||..|..|:.|.|....:..|::|.....||...|
Human   951 LFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	23/147 (16%)
		CUB	<414..512	CDD:238001	28/103 (27%)
		CUB	527..644	CDD:238001	31/117 (26%)
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808
		Astacin	155..348	CDD:279708
		CUB	349..458	CDD:278839	15/93 (16%)
		CUB	462..571	CDD:278839	23/162 (14%)
		FXa_inhibition	582..614	CDD:291342	4/31 (13%)
		CUB	618..727	CDD:278839	19/113 (17%)
		FXa_inhibition	734..769	CDD:291342	8/34 (24%)
		CUB	774..883	CDD:278839	33/129 (26%)
		CUB	887..1000	CDD:278839	31/126 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910