DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34402 and Tll1

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_033416.2	Gene:	Tll1 / 21892	MGIID:	106923	Length:	1013	Species:	Mus musculus

Alignment Length:	760	Identity:	140/760 - (18%)
Similarity:	251/760 - (33%)	Gaps:	229/760 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SFTVSHWPLTM-PAASLALGLTVV------------------------LLATGNGQSQQAVTNSK 43
            |:|...|.::: |...:.|..|.:                        ||....|.....|..|.
Mouse   371 SYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTST 435

  Fly    44 QSHFWLDCSCLHLSERNATQW---GRLAI-------------------NASHSLGAKNNCL-MIF 85
            .|..|::.       |:::.|   |..|:                   |..........|: .|.
Mouse   436 DSRMWIEF-------RSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIM 493

  Fly    86 IAGMDDELVAFQLEQLQLRAGC-LDSVDIFPYLREPVIENATLAADTFCQHSRERSATPIYSAGR 149
            ::......:.||..:::....| .|.:::    |:...||:.|.. .||.:.:
Mouse   494 VSEGYHVGLTFQAFEIERHDSCAYDHLEV----RDGASENSPLIG-RFCGYDK------------ 541

  Fly   150 LLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSF------------------CD 196
                       |.|:.|.:.||     ::|   |.:||.:....|                  |:
Mouse   542 -----------PEDIRSTSNTL-----WMK---FVSDGTVNKAGFAANFFKEEDECAKPDRGGCE 587

  Fly   197 FYFFASLSGEEANMGQGY-----------------------FHSPQFPAHYPAHIKCAYKFIGRP 238
            .....:|...:.....||                       ..:|.:|..||.:..|.::.|...
Mouse   588 QRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVIAPS 652

  Fly   239 DTHVEILFEELQLPPVVSGG--CQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEF 301
            ...:.:.||..:|    .|.  |:.|.:.::...|:. :.:....|.:.....:.|...::.:||
Mouse   653 QYRISVKFEFFEL----EGNEVCKYDYVEIWSGLSSE-SKLHGKFCGADIPEVMTSHFNNMRIEF 712

  Fly   302 NASSNRTAKGFRGKYKFVSNDLGVPNASVPPPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVE 366
            .:.:..:.|||:..: |...|                               ..:|:|.......
Mouse   713 KSDNTVSKKGFKAHF-FSDKD-------------------------------ECSKDNGGCQHEC 745

  Fly   367 LSKPGRSFEQCKQTFDSRVNKSGIFDS--NQLLLAKHALGGVVIG-------GSRVLQCRYEFEA 422
            ::..|....||:..|....||....::  .|.:   |:..|::..       .|| .:|.:...|
Mouse   746 VNTMGSYTCQCRNGFVLHENKHDCKEAECEQKI---HSPSGLITSPNWPDKYPSR-KECTWVISA 806

  Fly   423 QAPERVQIRFHDFNVPTEHENSTGCQPGDALHVV---TE---LRGRYETQELLCGAFLPKPLMSS 481
            ....|:.:.|::|.|....|.:.     |.|.:.   ||   :.||      |||:.:|.|||::
Mouse   807 IPGHRITLAFNEFEVEQHQECAY-----DHLEIFDGETEKSPILGR------LCGSKIPDPLMAT 860

  Fly   482 GQQLHLQFVGKYPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEGCSFVYNSSERISGLFHSPNF 546
            |.::.::|:.      ...||..||:|.:.  |..|.....:.:... :|:.::     |...|:
Mouse   861 GNEMFIRFIS------DASVQRKGFQATHS--TECGGRLKAESKPRD-LYSHAQ-----FGDNNY 911

  Fly   547 PGYYLENVVCNYYFYGASDERVVLHFTYFDIEGIGSCDHQTASDYIE-FSNFMSTDRKFSRYCGK 610
            ||    .:.|.:........|:.|.|..|::|....|.:    ||:| |....|......|:||.
Mouse   912 PG----QLDCEWLLVSERGSRLELSFQTFEVEEEADCGY----DYVEVFDGLSSKAVGLGRFCGS 968

  Fly   611 LPDFEMRSDGRFFRVTLHSNDRFVAIGFRALYTF----ETVSVNN 651
            .|..|:.|.|....:..|::|.....||...|..    ||:...|
Mouse   969 GPPEEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAKN 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	24/147 (16%)
		CUB	<414..512	CDD:238001	27/103 (26%)
		CUB	527..644	CDD:238001	29/117 (25%)
Tll1	NP_033416.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..150
		ZnMc_BMP1_TLD	148..347	CDD:239808
		Astacin	155..348	CDD:279708
		CUB	349..458	CDD:278839	17/93 (18%)
		CUB	462..571	CDD:278839	23/144 (16%)
		FXa_inhibition	582..614	CDD:291342	4/31 (13%)
		CUB	618..727	CDD:278839	20/113 (18%)
		FXa_inhibition	734..769	CDD:291342	8/34 (24%)
		CUB	774..883	CDD:278839	32/129 (25%)
		CUB	887..1000	CDD:278839	29/126 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910