DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and cubn

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	XP_021326049.1	Gene:	cubn / 100144772	ZFINID:	ZDB-GENE-060228-6	Length:	3626	Species:	Danio rerio

Alignment Length:	828	Identity:	173/828 - (20%)
Similarity:	284/828 - (34%)	Gaps:	224/828 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTVSHWPLTMPA---------------ASLALG-----------LTVVLLATGN----------- 32
            ||..::||..||               ..|:.|           ...:::..||
Zfish  1185 FTSPNYPLPYPANAECYWHIKTSAGSRIQLSFGDFHLEDTVDCYFDYLMVYDGNNSNAHQLAKLC 1249

  Fly    33 GQSQQAVTNSKQSHFWLDC---SCLH----LSERNATQWGRLAINAS----HSLGAKN------N 80
            |....|..:|.:.:.::..   |.:|    |:..::|..|.|..|.|    .||...|      :
Zfish  1250 GNQIPAPISSSRENMYVKLRTDSIIHTGGFLANYHSTCNGMLIANRSRGMIESLNYPNDYPSHAD 1314

  Fly    81 CLMIFIAGMDDEL----VAFQLEQLQLRAGC-LDSVDIFPYLREPVIENATLAADTFCQHSRERS 140
            |.....|.|.:.:    :||::||..   || .|.|.::    :...:.|.|.. |||.:....:
Zfish  1315 CSWTIQAYMGNTINYTFIAFEVEQSD---GCGYDHVKLY----DGPNDQANLIG-TFCGNVPPPA 1371

  Fly   141 ATPIYSAGRLLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSFCDFYFFASLSG 205
            .|   ::|..|.:..|..            ::.|||     .|:.|            ::.:..|
Zfish  1372 GT---TSGTSLHIVFRSD------------MSISYR-----GFQMD------------WYQNGCG 1404

  Fly   206 EEANMGQGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGGCQLDALTLF--- 267
            .|.....|.|:||.:|..||.:.:|.:.....|.:.:.|...|..:.  ....|..|.|.::
Zfish  1405 GELFGPVGTFNSPGYPGQYPMNRECVWHIHTSPGSSISITILEFDVE--YHPDCNYDKLEVYGGP 1467

  Fly   268 DAESAHMNSVIDVICSSRPTR---RLVSTGPDLLLEFNASSNRTAKGFRGKYKFVSNDLG----V 325
            |..:..:..    :|::||..   ::.|||..:.:.|.:.:..:.:||...:..|....|    .
Zfish  1468 DLSAPRLAQ----LCTTRPPSNPLQVSSTGNAVTVRFTSDAVVSGRGFNATWVEVPGGCGGSVTA 1528

  Fly   326 PNASVPPP----------------AVLEAASVVVKQEKLQ-QEQASAA-----------KENSLM 362
            |:..:..|                .|.....|......|. :.|.|.:           :.:.|:
Zfish  1529 PSGEIHSPQYPSNYPDNADCSWVITVDAGHRVFFNFTDLDIENQFSCSYDYVAIHDGPHEHSPLL 1593

  Fly   363 SDV-ELSKPGRSFEQCKQTF-----DSRVNKSGIFDSNQLLLAKHALGGVVIG---GSRVLQCRY 418
            :.| ..|:|..........:     |..:|..|.  |.|.   ..|.|..::.   |..:...||
Zfish  1594 AQVCGTSRPPPVTSSTNVIYVCFRSDHSLNHRGF--SAQF---SEACGSFIVTDDVGGEIASPRY 1653

  Fly   419 EF------------EAQAP-ERVQIRFHDFNVPTEHENST--GCQPGDALHVVTELRGRYETQEL 468
            .:            .||.| ..|.:.|.||.:...:.|.|  ..:..|..:|.....|||
Zfish  1654 PYPYPPNQDCSWIIRAQEPFNHVTLSFTDFELEMLNSNCTHDSVEILDGDNVQAPSVGRY----- 1713

  Fly   469 LCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEGCSFVYNS 533
             ||:.||.|:.|....:.::||..:      .|...||||.|...|:          ||..:.|.
Zfish  1714 -CGSNLPHPVTSLSNAMVVKFVSDH------AVGRKGFRATYMASTS----------GCGGLLNM 1761

  Fly   534 SERISGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTYFDIEGIGSCDHQTASDYIEFSNFM 598
            .   ||.|:|||:|..|..||.|.:....:...|:.|.|..|.::....|    ::||:|.....
Zfish  1762 E---SGAFNSPNYPDVYPPNVECVWTLTSSPGNRIQLSFIMFQLQPSSDC----SNDYLEIREGH 1819

  Fly   599 STDRKFSRYCG-KLPDFEMRSDGRFFRVTLHSNDRFVAIGFRALYTFETVSVNNSIT-------- 654
            ||.....|:|| .||.......|....:...|:......||||:::.   ...|.||
Zfish  1820 STGALVGRFCGDSLPTNYTSITGHILWIKFISDSSISGAGFRAVFSH---LYGNDITGSTGLIAS 1881

  Fly   655 -----DLRDNASMQSFVSTASTQPV------ANVNKLIACILCTYKAY 691
                 ...:||..:..|:..|...:      .::..|..|:....|.|
Zfish  1882 PLYPRTYPNNADYRWTVTVDSDSHIQIQFLDIDIEDLFNCLYDKLKIY 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	26/128 (20%)
		CUB	<414..512	CDD:238001	30/112 (27%)
		CUB	527..644	CDD:238001	34/117 (29%)
cubn	XP_021326049.1	EGF_CA	133..164	CDD:238011
		EGF_CA	167..208	CDD:238011
		EGF_CA	260..299	CDD:311536
		EGF_3	308..346	CDD:315598
		EGF_3	352..387	CDD:315598
		EGF_CA	397..430	CDD:238011
		EGF_CA	433..469	CDD:238011
		CUB	475..588	CDD:238001
		CUB	593..704	CDD:238001
		CUB	711..820	CDD:278839
		CUB	824..932	CDD:238001
		CUB	939..1049	CDD:278839
		CUB	1058..1166	CDD:278839
		CUB	1174..1285	CDD:238001	16/99 (16%)
		CUB	1287..1399	CDD:238001	32/151 (21%)
		CUB	1403..1515	CDD:238001	26/117 (22%)
		CUB	1522..1632	CDD:238001	17/114 (15%)
		CUB	1635..1750	CDD:238001	32/126 (25%)
		CUB	1755..1865	CDD:238001	34/116 (29%)
		CUB	1869..1979	CDD:238001	11/61 (18%)
		CUB	1994..2105	CDD:238001
		CUB	2108..2223	CDD:238001
		CUB	2228..2344	CDD:238001
		CUB	2347..2458	CDD:238001
		CUB	2463..2575	CDD:238001
		CUB	2581..2694	CDD:238001
		CUB	2697..2808	CDD:238001
		CUB	2813..2926	CDD:238001
		CUB	2928..3038	CDD:238001
		CUB	3041..3152	CDD:238001
		CUB	3161..3274	CDD:278839
		CUB	3281..3395	CDD:238001
		CUB	3399..3509	CDD:238001
		CUB	3514..3626	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910