Protein Alignment Su(var)3-9 and SETD1A

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_055527.1
• Gene: SETD1A / 9739
• HGNCID: 29010
• Length: 1707
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 97/428 - (22%)
• Similarity: 156/428 - (36%)
• Gaps: 124/428 - (28%)

  Fly   278 AKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAG-SRSQREPQKIGERALKS 341
            |..::..::.|||    ..:.|||.:..:|..||       |.|..| ...:.|.::..|.:..|
Human  1326 ALFSSPADEVLEA----PEVVVAEAEEPKPQQLQ-------QQREEGEEEGEEEGEEEEEESSDS 1379

  Fly   342 MQIKRAQ-FVRRKQLADLALFEKRMNHVEKPSPPIRVEN---------------NIDLDTIDSNF 390
            ......: .:||:.|...|  .:|......|.||.|...               |..||:.|.::
Human  1380 SSSSDGEGALRRRSLRSHA--RRRRPPPPPPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSY 1442

  Fly   391 M---------------------YIHDNIIGKDVPK----PEAGIVGCKCTEDTEECTASTKCCAR 430
            :                     ::|..|.....||    |:.|        ..|..|.|    ||
Human  1443 LRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDG--------PREHQTGS----AR 1495

  Fly   431 FAGEL-FAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSG----- 489
            ..|.. .:.:...:.|.:.|.||    ......|:..:||::...|.....|......|.
Human  1496 SEGYYPISKKEKDKYLDVCPVSA----RQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSD 1556

  Fly   490 -----------------------WGVRAATALRKGEFVCEYIGEIITSDEANERGKAY--DDNGR 529
                                   ||:.|...:...|.|.||:|:.|....|:.|.|.|  :..|.
Human  1557 LLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGS 1621

  Fly   530 TYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIK 593
            :|||.:|::|      .|||...||::.||||.|.||     |:.:.:.: :...:|.::.:||.
Human  1622 SYLFRVDHDT------IIDATKCGNLARFINHCCTPN-----CYAKVITIESQKKIVIYSKQPIG 1675

  Fly   594 AGEELSFDYIRADNEDVPYENLSTAVRVECRCGADNCR 631
            ..||:::||      ..|.|:    .::.|.||.::||
Human  1676 VDEEITYDY------KFPLED----NKIPCLCGTESCR 1703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793
		SET_SUV39H	388..634	CDD:380940	68/301 (23%)
SETD1A	NP_055527.1	Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068	60..89
		RRM_Set1A	92..186	CDD:409964
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..308
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..363
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..486
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..655
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..854
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..1251
		PRK12323	<1070..>1130	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1264..1293
		HCFC1-binding motif (HBM)	1299..1303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1307..1417		25/103 (24%)
		Interaction with CFP1	1415..1450		4/34 (12%)
		N-SET	1425..1562	CDD:463344	26/152 (17%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332	1450..1537		19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1472..1499		9/38 (24%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	1492..1497		3/8 (38%)
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1537..1542		1/4 (25%)
		SET_SETD1	1556..1703	CDD:380946	44/167 (26%)