Protein Alignment Su(var)3-9 and setd1b

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001072649.1
• Gene: setd1b / 780106
• XenbaseID: XB-GENE-5842344
• Length: 1956
• Species: Xenopus tropicalis
• Alignment Length: 642
• Identity: 129/642 - (20%)
• Similarity: 220/642 - (34%)
• Gaps: 222/642 - (34%)

  Fly   131 SSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGC---------EEHD-------------V 173
            |..|...:|...||..|..:.|...|.::    |:|.|         :|.|             :
 Frog  1398 SQSPGIINSGIPRTPGRDFNFTPTFPESN----SIFPCHPSGKKPSVDEPDEKSFKEPTSASLTM 1458

  Fly   174 DKIPSLNGFA-----------------------------KLKRRRSSC-----------VGAPTP 198
            :.:||...||                             ||....|.|           ..||:|
 Frog  1459 NSVPSPIPFASPPRGLPHMDIRLGADDLESSDTPAYLSDKLLSEESECEFTKVHLTSTDESAPSP 1523

  Fly   199 NSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYH--DSENTWESLANVA---D 258
            ....::...|..:|:|                          |..|  ::|..:|:.:.||   .
 Frog  1524 PLPPAEKRKGDRSKKP--------------------------LSAHEFETEKNYETSSAVAMSEG 1562

  Fly   259 CAEMEKFVERHQQLYEIYIAKITTELEKQLEALPL-MENITVAEVDAYEPLNLQIDLILLAQY-- 320
            ....:.|:.:...:..|          |...|:|| ..|.:::|...:||:..::.|..|...
 Frog  1563 ALGKQMFIGQPDAVSGI----------KDPAAVPLDFRNDSLSENTVHEPIIQKVPLKELENQWN 1617

  Fly   321 ----------RAAGSRSQREPQKIGE-RALKSMQIK--RAQFVRRKQLADLALFEKRMNHVEKPS 372
                      :...||:.|...:..| ..:.|.:..  ||.|..|.:..::.:.....|.
 Frog  1618 EVLKEEEDITKHKKSRNSRHNNRYDEFSTVPSPEFSPPRAMFKPRSEFEEMTILYDIWNG----- 1677

  Fly   373 PPIRVENNIDLDTIDSNFMYI-HDNIIGKD-----------VPKPEAGIVGCKCTEDTEECTAST 425
                     .:|..|..:|.| :|.::.:|           |..|...:...|..:..:......
 Frog  1678 ---------GIDDEDIKYMCITYDRLLQQDNGMDWLNDTLWVYHPSTSVYSPKKKKRDDGLREHV 1733

  Fly   426 KCCARFAGELFAYERSTRRLRLRPGSAIYECNSR------------------------------- 459
            ..|||..|    |.:..::.:|:     |..|:|
 Frog  1734 TGCARSEG----YYKIDKKDKLK-----YLINNRSLTEELPIDTQGKSIPAQPQASTRAGSERRS 1789

  Fly   460 ------CSCDSSCSNRLVQHGR---QVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSD 515
                  .|...||.:.|::..:   :...:.|..::...||:.|...:...|.|.||:|:.|...
 Frog  1790 EQRRLLSSFTGSCDSDLLKFNQLKFRKKKLRFCKSHIHDWGLFAMEPIIADEMVIEYVGQNIRQV 1854

  Fly   516 EANERGKAYDDN--GRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLN 578
            .|:.|.|.|:|.  |.:|:|.:|::|      .|||...||.:.||||||:||     |:.:.:.
 Frog  1855 IADMREKRYEDEGIGSSYMFRVDHDT------IIDATKCGNFARFINHSCNPN-----CYAKVIT 1908

  Fly   579 V-ALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGADNCRKVL 634
            | :...:|.::.:.|...||:::||      ..|.|:    |::.|.|||:|||..|
 Frog  1909 VESQKKIVIYSKQYINVNEEITYDY------KFPIED----VKIPCLCGAENCRGTL 1955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	7/53 (13%)
		SET_SUV39H	388..634	CDD:380940	71/300 (24%)
setd1b	NP_001072649.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		RRM_Set1B	119..211	CDD:409965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..478
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..637
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..696
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..1148
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1341..1386
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1420..1464		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1512..1553		9/66 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1627..1655		5/27 (19%)
		N-SET	1669..1811	CDD:463344	23/164 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1766..1790		0/23 (0%)
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1788..1793		0/4 (0%)
		SET_SETD1	1805..1952	CDD:380946	50/167 (30%)