Protein Alignment Su(var)3-9 and NSD2

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 143/659 - (21%)
• Similarity: 210/659 - (31%)
• Gaps: 224/659 - (33%)

  Fly    83 LSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRR 147
            :|.||.:..:|:|::             ::.:|........||..|...:...:...:.||...|
Human   686 VSSKKSERGVTAKKE-------------YVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGR 737

  Fly   148 STSQTSLSPSNSSGYGSVFGCEEHDVD-------------------KIP----SLNGFAKLKRRR 189
            .|....     :||..|.|.|:|...|                   |.|    ...||   :...
Human   738 FTCSEC-----ASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGF---RCPL 794

  Fly   190 SSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLA 254
            .|||.....|...         .||.||    :.:.||..    ||      .||..:   ..||
Human   795 HSCVSCHASNPSN---------PRPSKG----KMMRCVRC----PV------AYHSGD---ACLA 833

  Fly   255 NVADCAEMEK--------FVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQ 311
              |.|:.:..        |..|..:.:..::......:..:..:|...|:...    |:.|..|.
Human   834 --AGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPA----AFHPDCLN 892

  Fly   312 IDL-----------------------ILLAQYR----------AAGSRSQREPQKIGE------- 336
            |::                       :.|..||          ......|:...:|||
Human   893 IEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFG 957

  Fly   337 ----------RALKSMQIKRAQ-----------FVRRKQLADLALFE-------KRMNHVEKPSP 373
                      |....|:..|..           |....|.|:....|       :.....|:..|
Human   958 SKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPP 1022

  Fly   374 P---IRVE---NNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKC-TEDTEECTASTKCCARF 431
            |   |:|.   ..:.:.|.|.:           ::||       |.| ..|...|...::|..|.
Human  1023 PYKHIKVNKPYGKVQIYTADIS-----------EIPK-------CNCKPTDENPCGFDSECLNRM 1069

  Fly   432 AGELFAYERSTRRLRLRPGSAIYECNSR-CSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAA 495
                                .::||:.: |.....|.|:.... ||.|.......:|.|||:.|.
Human  1070 --------------------LMFECHPQVCPAGEFCQNQCFTK-RQYPETKIIKTDGKGWGLVAK 1113

  Fly   496 TALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFIN 560
            ..:||||||.||:||:|..:|...|.|...:|..|:.:.|..    |.:..|||...||.|.|:|
Human  1114 RDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI----DKDRIIDAGPKGNYSRFMN 1174

  Fly   561 HSCDPNLAVFPCWIEH--LNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTA--VRV 621
            |||.||..... |..:  ..|.|     |.:..|.||.||:|:|           ||...  .:.
Human  1175 HSCQPNCETLK-WTVNGDTRVGL-----FAVCDIPAGTELTFNY-----------NLDCLGNEKT 1222

  Fly   622 ECRCGADNC 630
            .|||||.||
Human  1223 VCRCGASNC 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	11/56 (20%)
		SET_SUV39H	388..634	CDD:380940	72/249 (29%)
NSD2	NP_001427822.1	None