Protein Alignment Su(var)3-9 and ezh1

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001035072.2
• Gene: ezh1 / 664754
• ZFINID: ZDB-GENE-050114-1
• Length: 756
• Species: Danio rerio
• Alignment Length: 593
• Identity: 122/593 - (20%)
• Similarity: 213/593 - (35%)
• Gaps: 155/593 - (26%)

  Fly    67 RFKNELERNITIKLERLSEKKIKNLLTSKQQRQQ-----YEIKQRSMLRHLAEL----------R 116
            ::.:.||.:..:||..|....:........||:|     :.:..|...::...|          :
Zfish   280 KYLDLLEPSNHVKLPPLCTPNMDGPFAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHSSPNVYK 344

  Fly   117 RHSRFRRLCTKP---------------ASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVF 166
            |.|:...:.|:|               |..:|..|..:..||...|.:|....:|.:||..|..
Zfish   345 RKSKEIHMETEPCGLDCFLLQKGAKEFADQNMMRSQRTRRRRRQPRPSSSCGHTPPDSSEKGKE- 408

  Fly   167 GCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQ 231
            |..:|:.......|         |.|   |:|...:........:|.||:.....|.:
Zfish   409 GGSDHETTSSSEGN---------SRC---PSPIKMKPGEEESKESKSPPQWSGAEESL------- 454

  Fly   232 YQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMEN 296
                |.|....|:::..:...|.....|.|:.:|..:                |..::.:||.:
Zfish   455 ----FRVLHGTYYNNFCSIARLIGTKTCREVYEFAVK----------------EVLIDRMPLED- 498

  Fly   297 ITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALF 361
                                      :|...|::.:|  .|....:|:|:
Zfish   499 --------------------------SGISPQKKKRK--HRLWAKIQLKK--------------- 520

  Fly   362 EKRMNHVEKPSPPIRVENNIDLD---TIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEE--- 420
            :...|.|....|....|:..|..   .|..||....                 |:|..:.:.
Zfish   521 DNSSNQVYNYQPCDHPEHPCDSSCPCVITQNFCEKF-----------------CQCDRECQNRFP 568

  Fly   421 -CTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKT 484
             |...|:|..:......|.......|.:..|:|.:..:.:.|| .:||   :|.|.:..|:| ..
Zfish   569 GCRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKQVSC-KNCS---IQRGLKKHLLL-AP 628

  Fly   485 ANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDA 549
            ::.:|||......::|.||:.||.||:|:.|||:.||:.||....::||:|      ::::.:||
Zfish   629 SDVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNL------NNDFVVDA 687

  Fly   550 ANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLV-FFTLRPIKAGEELSFDYIRADNEDVPYE 613
            ...||...|.|||.:||     |:.:.:.|...|.: .|..|.|:.||||.|||..:..:.:.|.
Zfish   688 TRKGNKIRFANHSVNPN-----CYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKYV 747

  Fly   614 NLSTAVRV 621
            .:...:.:
Zfish   748 GIEREIEI 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	2/12 (17%)
		Chromo	219..268	CDD:459793	8/48 (17%)
		SET_SUV39H	388..634	CDD:380940	64/239 (27%)
ezh1	NP_001035072.2	EZH2_WD-Binding	45..74	CDD:463308
		PRC2_HTH_1	164..286	CDD:436286	0/5 (0%)
		SANT	447..489	CDD:238096	8/68 (12%)
		preSET_CXC	569..600	CDD:408079	5/30 (17%)
		SET_EZH1	617..752	CDD:380994	49/146 (34%)