Protein Alignment Su(var)3-9 and NSD1

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 85/301 - (28%)
• Similarity: 128/301 - (42%)
• Gaps: 69/301 - (22%)

  Fly   340 KSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENN-----IDLDTIDSNFMYIHDNIIG 399
            |::|...|:|...|...:|...::...:.:||.|...::.|     :.:.|.|.:
Human  1836 KALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLS---------- 1890

  Fly   400 KDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECN-SRCSCD 463
             ::|:     ..||.| |...|...::|..|.                    .:|||: :.|...
Human  1891 -EIPR-----CNCKAT-DENPCGIDSECINRM--------------------LLYECHPTVCPAG 1928

  Fly   464 SSCSNRLVQHGRQVPLV-LFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDN 527
            ..|.|:.... ||.|.| :|:|.. .|||:|..|.::|||||.||:||:|..:|...|.:...::
Human  1929 GRCQNQCFSK-RQYPEVEIFRTLQ-RGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEH 1991

  Fly   528 GRT--YLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTL 589
            ..|  |:..|      |.:..|||...||.:.|:||.|.||     |..:..:| ....:..|.|
Human  1992 DITNFYMLTL------DKDRIIDAGPKGNYARFMNHCCQPN-----CETQKWSVNGDTRVGLFAL 2045

  Fly   590 RPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGADNC 630
            ..||||.||:|:|        ..|.|.....| |:|||.||
Human  2046 SDIKAGTELTFNY--------NLECLGNGKTV-CKCGAPNC 2077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793
		SET_SUV39H	388..634	CDD:380940	73/248 (29%)
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311
		PWWP_NSD1_rpt1	318..433	CDD:438989
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428
		TNG2	<1431..1587	CDD:227367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		PWWP_NSD1_rpt2	1755..1850	CDD:438992	4/13 (31%)
		AWS	1901..1939	CDD:465559	10/58 (17%)
		SET_NSD1	1941..2082	CDD:380987	57/158 (36%)
		Inhibits enzyme activity in the absence of bound histone	2060..2066		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111
		PHD5_NSD1	2120..2162	CDD:277129
		C5HCH	2161..2210	CDD:465605
		PHA03247	<2208..2574	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696