Protein Alignment Su(var)3-9 and set-25

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_499738.3
• Gene: set-25 / 3565129
• WormBaseID: WBGene00012802
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 724
• Identity: 163/724 - (22%)
• Similarity: 247/724 - (34%)
• Gaps: 243/724 - (33%)

  Fly    57 VKAISGVQTVRFKNELE-RNITIKLERLS-----------EKKIKNLLTSKQQRQQYEIKQRSML 109
            :.|....|:.|..|.:| |...:...|.|           |..:.....||....|...|| |.|
 Worm    85 ISATDATQSSRTMNVIEDRKPRVNRARKSQDAPSTSTCGFETPVGTKRKSKAADSQKPPKQ-SKL 148

  Fly   110 RHLAELRRHSRFRRLCTKPASSSMPASTSSVD-RRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDV 173
            |.:.|              ||:|.....||.| ::||:.:.:|::...|..|            :
 Worm   149 RKIDE--------------ASTSKAVDNSSKDGKKTTKPAVTQSNRRRSGLS------------L 187

  Fly   174 DKIPSLNGFAKLKRRRSSC-----VGAPTPNSKRSKNNMGVIAKRPPKGEYV-VERIECVEMDQY 232
            ..:|....|::...|.||.     |.......|.:||.:.|:......|.|. .|||..|
 Worm   188 RPVPIETIFSESSGRESSTEDEADVSHQQRVEKIAKNPIMVVVLPLGPGNYPNNERITVV----- 247

  Fly   233 QPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENI 297
                           :|::|..| .:|.|..: .:||.......||         ...:| .:..
 Worm   248 ---------------STYKSRVN-KNCNEARR-AQRHGSWSRKGIA---------FPGIP-TKKF 285

  Fly   298 TVAEVDAYEPLNLQIDLILLAQYRAAGSR-----------------------------SQREPQK 333
            |.::               ||:|.|..|.                             |..|..:
 Worm   286 TKSD---------------LAKYGAHASNWPAQAAFRSEEGKILIYYEGWTCLTLHRLSVEECAR 335

  Fly   334 IGERALKSMQIKRAQFVR-----RKQLADLALFEKRMNHVE------------KPSPPIRVENNI 381
            .....|:.|.| |.:|:.     ..:.|.|.:.:.:.|.:|            :|.|....||..
 Worm   336 TAPTILEEMSI-RDKFIETVKSAAAEEAKLVVEKNQENGIELTLDEALKQIFIEPVPQSSPENVF 399

  Fly   382 ----DLD---TIDSN---------------------FMYIHDNIIGKDVPKPEAGIVGCKCTED- 417
                ||.   |:|:.                     :.|...||:..|..|        :|.|.
 Worm   400 WIYQDLSYFHTMDNRDLGLAPVFYISSYTQSVRPPCYAYTAINIVDVDAYK--------RCLESR 456

  Fly   418 ------------------TEECTASTKC-C-ARFAGELFAYE-RSTRRLRLRP------------ 449
                              ::.|...||| | |||   :|.|: .....|...|
 Worm   457 ANMSFADLTGQKIWMPTRSKACENGTKCKCDARF---MFLYDPHDVTNLECTPDGKVDFTDFKID 518

  Fly   450 -GSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEII- 512
             ...:.||:..|.|...|..|.:|.|:|.||.::......|:|||||..::.||.||||.|::.
 Worm   519 NARIVMECSDACGCSLDCPRRSLQRGQQHPLAVYYEGPEKGFGVRAAANIKAGELVCEYTGDVTL 583

  Fly   513 --TSD------------EANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSC 563
              |||            |..|..:|.:....:|  |..:| |.|::..|.|...||||.||||||
 Worm   584 LPTSDPVASSSTKTDDGEEQENPEAPERVDSSY--DAAFN-AMDTKIIISAKKTGNISRFINHSC 645

  Fly   564 DPN---LAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRC 625
            ||:   :.|:....|. :..:|.:..:.::.|..|||::..|.   ...:.::..|    |:|||
 Worm   646 DPSSVFVEVYSRRFEE-DPLIPRVAVYAIKDIALGEEITIAYY---EPGIEWKRSS----VKCRC 702

  Fly   626 GADNCRKVL 634
            .:..|...|
 Worm   703 KSTKCMGTL 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	6/23 (26%)
		Chromo	219..268	CDD:459793	10/49 (20%)
		SET_SUV39H	388..634	CDD:380940	82/319 (26%)
set-25	NP_499738.3	SET	<525..711	CDD:394802	63/196 (32%)