Protein Alignment Su(var)3-9 and lin-59

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_491206.1
• Gene: lin-59 / 266825
• WormBaseID: WBGene00003040
• Length: 1312
• Species: Caenorhabditis elegans
• Alignment Length: 634
• Identity: 125/634 - (19%)
• Similarity: 219/634 - (34%)
• Gaps: 230/634 - (36%)

  Fly    71 ELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPA 135
            |:.:.|.:::..||.::.|     |::..:.|:...:.....|   |.:|.|..|...:::|...
 Worm   297 EMAKAIAMRIRELSAEESK-----KKKDMEAEVSSTTPTTPRA---RGTRTRNKCATRSTNSPDV 353

  Fly   136 STSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNS 200
            :||::....   |||...|...|            .||:|:.......|.|:||
 Worm   354 TTSNLPEEP---STSTMGLVKEN------------EDVEKVEGKRRGRKPKKRR----------- 392

  Fly   201 KRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKF 265
                                                     |:|.     ||..::...|:..|.
 Worm   393 -----------------------------------------GFHK-----ESFEDLESDAKKSKA 411

  Fly   266 VERHQQLYEI------------------YIAKITTELEKQLEAL--PLMENITVAEVDAYEPLNL 310
            .:....|.|.                  :..|:...:|::||.|  .:.|::|...:..
 Worm   412 EQHEDHLPEASCSSRPESVIPPPVDPIQFRLKVREMMERKLEQLTQKMSEDMTELRLSH------ 470

  Fly   311 QIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQL----ADLALFEKRMNHVEK- 370
                 |.:.....|.|.:|....:.:...:|.::::...:.||:|    .:..:.|:..::::|
 Worm   471 -----LTSSKMVNGERGKRRESFLRQLNEQSKKLRKGGMLGRKRLRMFMTESDILEENKDNIKKE 530

  Fly   371 -----PSPPIRVENN------------IDLDTIDSNF--MYIHDNIIGKDVPKPE-------AGI 409
                 ..||.::...            ::.:.::..|  .|..   |.|.||..:       |..
 Worm   531 VKEESTPPPTKLRGRLPSRRTREPSEIVNPEPVEKKFNGEYFE---ITKSVPSSDDIIPLWMAPS 592

  Fly   410 VGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCS---CDS------S 465
            :.|.||:..  ||:...|.             .|.||:       :|:|.||   |.:      .
 Worm   593 LTCGCTKGA--CTSDMDCL-------------NRALRV-------QCSSDCSVPYCSNRRFWKED 635

  Fly   466 CSNRL-VQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGR 529
            |.|:| |.:|.:...||           :...|.|.|||:|||.||:||.::|.|: .|.|.:.|
 Worm   636 CGNKLCVSNGPRSKRVL-----------KTKIARRAGEFLCEYAGEVITREQAQEK-FAQDRDPR 688

  Fly   530 -----TYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNV----ALPHLV 585
                 .:||             :||....||:.||.|||.||        ..|.|    ......
 Worm   689 IIAIAAHLF-------------VDATKRSNIARFIKHSCKPN--------SRLEVWSVNGFYRAG 732

  Fly   586 FFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGADNCRKVL 634
            .|.|..:....|::.|    .::.:|::       :.|.|||..|::|:
 Worm   733 VFALSDLNPNAEITVD----KSDLLPFD-------MACNCGATECKRVI 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	2/8 (25%)
		Chromo	219..268	CDD:459793	6/48 (13%)
		SET_SUV39H	388..634	CDD:380940	70/273 (26%)
lin-59	NP_491206.1	AWS	591..636	CDD:197795	14/66 (21%)
		SET	629..772	CDD:394802	50/186 (27%)
		PHD	970..1027	CDD:425785
		BAH_polybromo	1118..1222	CDD:240068