Protein Alignment Su(var)3-9 and SETD1B

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001340274.1
• Gene: SETD1B / 23067
• HGNCID: 29187
• Length: 1966
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 72/255 - (28%)
• Similarity: 115/255 - (45%)
• Gaps: 48/255 - (18%)

  Fly   385 TID--SNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRL 447
            |||  ....|::.:....|  :|.|...|........   |||:     ||.    ||.:.:.||
Human  1754 TIDKKDKLRYLNSSRASTD--EPPADTQGMSIPAQPH---ASTR-----AGS----ERRSEQRRL 1804

  Fly   448 RPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEII 512
                 :......|..|....|:|....:::.   |..::...||:.|...:...|.|.||:|:.|
Human  1805 -----LSSFTGSCDSDLLKFNQLKFRKKKLK---FCKSHIHDWGLFAMEPIAADEMVIEYVGQNI 1861

  Fly   513 TSDEANERGKAYDDN--GRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIE 575
            ....|:.|.|.|:|.  |.:|:|.:|::|      .|||...||.:.||||||:||     |:.:
Human  1862 RQVIADMREKRYEDEGIGSSYMFRVDHDT------IIDATKCGNFARFINHSCNPN-----CYAK 1915

  Fly   576 HLNV-ALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGADNCRKVL 634
            .:.| :...:|.::.:.|...||:::||      ..|.|:    |::.|.||::|||..|
Human  1916 VITVESQKKIVIYSKQHINVNEEITYDY------KFPIED----VKIPCLCGSENCRGTL 1965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793
		SET_SUV39H	388..634	CDD:380940	68/248 (27%)
SETD1B	NP_001340274.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068	68..98
		RRM_Set1B	101..193	CDD:409965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..719
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1462
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1501..1541
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1606
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1668
		N-SET	1679..1821	CDD:463344	19/85 (22%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	1745..1750
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1767..1800		11/46 (24%)
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1798..1803		0/4 (0%)
		SET_SETD1	1815..1962	CDD:380946	51/170 (30%)