Protein Alignment Su(var)3-9 and mes-4

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_506333.1
• Gene: mes-4 / 179824
• WormBaseID: WBGene00003222
• Length: 898
• Species: Caenorhabditis elegans
• Alignment Length: 607
• Identity: 135/607 - (22%)
• Similarity: 199/607 - (32%)
• Gaps: 218/607 - (35%)

  Fly    71 ELERNITI--KLERL-------------------SEKKIKNLLTSKQQRQQYEIKQRSMLRHLAE 114
            :|..:|||  |:|:.                   ..||.||.:|...:               |:
 Worm   247 DLNVSITIGGKVEKFEMIICPAHYLPGADVQFYNKHKKRKNAVTVVPK---------------AD 296

  Fly   115 LRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSL 179
            :...|..:..|......|               |.|:|.:..:....:.|  ||.|     :.:|
 Worm   297 VTMKSHIKACCVIGCEKS---------------SNSKTIMCKTCCRSFHS--GCRE-----VETL 339

  Fly   180 NGFAKLKRRRSSCV-GAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGY 243
            ||......:..||| |.|.|      .|..::||......::...::              |..|
 Worm   340 NGKPIPDDQCESCVCGDPIP------QNTLILAKWTDNSFWLALTLD--------------WYKY 384

  Fly   244 HDSEN---TWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDAY 305
            .....   .:|.|.                  |.:....|..|.:|  |..|||..:.|:::
 Worm   385 PTGNRGNINFERLG------------------YTVVQWLIPQENDK--EKQPLMSIVPVSDI--- 426

  Fly   306 EPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEK 370
              ..|..:...||                     |:..::.....:.::.||.||  ||..:|.|
 Worm   427 --ARLTKNYFSLA---------------------KNSTLRNLWEEKYEEQADTAL--KRCPYVCK 466

  Fly   371 PSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEA--GIVGCKCTEDTEECTASTKCCARFAG 433
                          |:   |..:..::..|..||.|.  ....|.| |..:.||..:  |...|.
 Worm   467 --------------TV---FGRLRTSVYYKCEPKLEEYHNNEVCNC-EGADRCTKLS--CQYLAD 511

  Fly   434 ELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATAL 498
            :                   |||...||....|.||.|..|.....:........|:||.|...:
 Worm   512 D-------------------YECPPSCSKKGVCHNRQVSMGIVSEKIKLAATLCKGYGVFAKGQI 557

  Fly   499 RKGEFVCEYIGEIITSDEANER----GKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFI 559
            .|.|::|||:||||...|...|    ..:.|.....|:.:|      ....|:|||.|||||.:|
 Worm   558 EKDEYICEYVGEIIDKAEKKRRLDSVSISRDFQANHYMMEL------HKGLTVDAARYGNISRYI 616

  Fly   560 NHSCDPNLAVFPCWIEHLNVALPHLVFF----------------TLRPIKAGEELSFDYIRADNE 608
            |||||||.|.|..           .||.                .:|.|..|:|::|.|...:.|
 Worm   617 NHSCDPNAASFVT-----------KVFVKKTKEGSLYDTRSYIRAIRTIDDGDEITFSYNMNNEE 670

  Fly   609 DVPYENLSTAVRVECRCGADNC 630
            ::|          :|.|||:||
 Worm   671 NLP----------DCECGAENC 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	4/10 (40%)
		Chromo	219..268	CDD:459793	4/51 (8%)
		SET_SUV39H	388..634	CDD:380940	75/265 (28%)
mes-4	NP_506333.1	SET_SETD2-like	538..683	CDD:380929	53/172 (31%)