DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)3-9 and Ezh2

DIOPT Version :10

Sequence 1:NP_524357.2 Gene:Su(var)3-9 / 41483 FlyBaseID:FBgn0263755 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_001396739.1 Gene:Ezh2 / 14056 MGIID:107940 Length:751 Species:Mus musculus


Alignment Length:541 Identity:114/541 - (21%)
Similarity:193/541 - (35%) Gaps:183/541 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 RRHSRFRRLCTKPASSSMPASTS-----SVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDK 175
            ||..|.      |.:||.|::.:     |.|..:.|.:.::|              |.|.:|.::
Mouse   358 RRRGRL------PNNSSRPSTPTISVLESKDTDSDREAGTET--------------GGENNDKEE 402

  Fly   176 IPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKW 240
                      :.::.....:...||:         .:.|.|.:..:|..|.||....:...|...
Mouse   403 ----------EEKKDETSSSSEANSR---------CQTPIKMKPNIEPPENVEWSGAEASMFRVL 448

  Fly   241 LG-YHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDA 304
            :| |:|:......|.....|.::.:|..:...:    ||.:.||                 :|| 
Mouse   449 IGTYYDNFCAIARLIGTKTCRQVYEFRVKESSI----IAPVPTE-----------------DVD- 491

  Fly   305 YEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVE 369
                              ...|.::...::.....:.:|:|:               :...|||.
Mouse   492 ------------------TPPRKKKRKHRLWAAHCRKIQLKK---------------DGSSNHVY 523

  Fly   370 KPSPPIRVENNIDLD---TIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARF 431
            ...|........|..   .|..||                     |:     :.|..|::|..||
Mouse   524 NYQPCDHPRQPCDSSCPCVIAQNF---------------------CE-----KFCQCSSECQNRF 562

  Fly   432 AGELFAYERSTRRLRLRPGSAIYECNSR-CSC---------------------DS---SCSNRLV 471
            .|           .|.:.     :||:: |.|                     ||   ||.|..:
Mouse   563 PG-----------CRCKA-----QCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 611

  Fly   472 QHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLD 536
            |.|.:..|:| ..::.:|||:.....::|.||:.||.||||:.|||:.|||.||....::||:| 
Mouse   612 QRGSKKHLLL-APSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNL- 674

  Fly   537 YNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLV-FFTLRPIKAGEELSF 600
                 ::::.:||...||...|.|||.:||     |:.:.:.|...|.: .|..|.|:.||||.|
Mouse   675 -----NNDFVVDATRKGNKIRFANHSVNPN-----CYAKVMMVNGDHRIGIFAKRAIQTGEELFF 729

  Fly   601 DYIRADNEDVPYENLSTAVRV 621
            ||..:..:.:.|..:...:.:
Mouse   730 DYRYSQADALKYVGIEREMEI 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)3-9NP_524357.2 PTZ00327 11..>80 CDD:240362
Chromo 219..268 CDD:459793 11/49 (22%)
SET_SUV39H 388..634 CDD:380940 70/260 (27%)
Ezh2NP_001396739.1 Interaction with EED 39..68
EZH2_WD-Binding 39..68 CDD:463308
PRC2_HTH_1 158..249 CDD:436286
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..217
Interaction with CDYL. /evidence=ECO:0000250 334..527 41/262 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..431 18/111 (16%)
preSET_CXC 564..595 CDD:408079 6/46 (13%)
SET_EZH2 614..733 CDD:380995 49/130 (38%)
Blue background indicates that the domain is not in the aligned region.

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