Protein Alignment Su(var)3-9 and Nsd2

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001074571.2
• Gene: Nsd2 / 107823
• MGIID: 1276574
• Length: 1366
• Species: Mus musculus
• Alignment Length: 670
• Identity: 145/670 - (21%)
• Similarity: 217/670 - (32%)
• Gaps: 233/670 - (34%)

  Fly    81 ERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTT 145
            |...|.:.:..::||:..:....|:    .::.:|...:....||..|...:...:...:.||..
Mouse   643 ESADETQTEASVSSKKSERGMAAKK----EYVCQLCEKTGSLLLCEGPCCGAFHLACLGLSRRPE 703

  Fly   146 RRSTSQTSLSPSNSSGYGSVFGCEE-----------------HD--VDKIP----SLNGFAKLKR 187
            .|.|....     :||..|.|.|:|                 |:  |.|.|    ...||   :.
Mouse   704 GRFTCTEC-----ASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGF---RC 760

  Fly   188 RRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWES 252
            ...||:.....|...         .||.||    :.:.||..    ||      .||..:   ..
Mouse   761 PLHSCMSCHASNPSN---------PRPSKG----KMMRCVRC----PV------AYHGGD---AC 799

  Fly   253 LANVADCAEMEK--------FV----ERHQQLYEIYIAKITTELEKQL--EALPLMENITVAEVD 303
            ||  |.|:.:..        |.    :||.....:....:.::....|  ||.|.
Mouse   800 LA--AGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCCEACPA---------- 852

  Fly   304 AYEPLNLQIDL-----------------------ILLAQYR---AAGSRSQREPQKI-------- 334
            |:.|..|.|::                       :.|..||   |.....:..|..|
Mouse   853 AFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIG 917

  Fly   335 -------------------------GERALKSMQIKRAQFVRRKQLADLALFEKRMNHVE----- 369
                                     |:|..:...::....|.:..|.:.   |.|.|.|:
Mouse   918 EFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEA---EARFNEVKLQREA 979

  Fly   370 --------KPSPPIRVENN-----IDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKC-TEDTEE 420
                    ||.|...::.|     :.:.|.|.:           ::||       |.| ..|...
Mouse   980 RETQESERKPPPYKHIKVNKPYGKVQIYTADIS-----------EIPK-------CNCKPTDENP 1026

  Fly   421 CTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSR-CSCDSSCSNRLVQHGRQVPLVLFKT 484
            |.:.::|..|.                    .::||:.: |.....|.|:.... ||.|......
Mouse  1027 CGSDSECLNRM--------------------LMFECHPQVCPAGEYCQNQCFTK-RQYPETKIIK 1070

  Fly   485 ANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDA 549
            .:|.|||:.|...:||||||.||:||:|..:|...|.|...:|..|:.:.|..    |.:..|||
Mouse  1071 TDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI----DKDRIIDA 1131

  Fly   550 ANYGNISHFINHSCDPNLAVFPCWIEH--LNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPY 612
            ...||.|.|:||||.||..... |..:  ..|.|     |.:..|.||.||:|:|
Mouse  1132 GPKGNYSRFMNHSCQPNCETLK-WTVNGDTRVGL-----FAVCDIPAGTELTFNY---------- 1180

  Fly   613 ENLSTA--VRVECRCGADNC 630
             ||...  .:..|||||.||
Mouse  1181 -NLDCLGNEKTVCRCGASNC 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	11/60 (18%)
		SET_SUV39H	388..634	CDD:380940	72/249 (29%)
Nsd2	NP_001074571.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..169
		PWWP_NSD2_rpt1	220..347	CDD:438990
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..455
		HMG-box_NSD2	452..507	CDD:438807
		TNG2	<546..711	CDD:227367	13/71 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..659		4/15 (27%)
		PHD1_NSD1_2	670..712	CDD:277118	8/46 (17%)
		PHD2_NSD2	717..763	CDD:277121	10/48 (21%)
		PHD3_NSD2	764..817	CDD:277124	17/80 (21%)
		PHD_SF	834..874	CDD:473978	8/49 (16%)
		PWWP_NSD2_rpt2	880..975	CDD:438993	14/97 (14%)
		AWS	1013..1063	CDD:197795	14/77 (18%)
		SET_NSD2	1063..1204	CDD:380988	57/158 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1207..1233
		PHD5_NSD2	1242..1284	CDD:277130
		C5HCH	1283..1328	CDD:465605
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1330..1366