DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12213 and RNF214

DIOPT Version :9

Sequence 1:	NP_001097754.1	Gene:	CG12213 / 41447	FlyBaseID:	FBgn0260742	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001070707.1	Gene:	RNF214 / 257160	HGNCID:	25335	Length:	703	Species:	Homo sapiens

Alignment Length:	400	Identity:	91/400 - (22%)
Similarity:	164/400 - (41%)	Gaps:	60/400 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SQHQLDESRAFQEGLSVQMQSLNAEKLTAEKRMSALRSEKMTLQEQYEGQLAEALQKQHDTEH-- 96
            |..:|.::.|.|.........:|.:: ..||.:..:.:|:..|:|:|:    |.|.||...|:
Human   195 SSLKLSQNIAVQTDFKTADSEVNTDQ-DIEKNLDKMMTERTLLKERYQ----EVLDKQRQVENQL 254

  Fly    97 -----ALQEKFDAQVEKYK--LLEIKYTNLEAEFVKSKKKHIEDTNAFDQKLQKVLADLHKDKAS 154
                 .||::.:.:::.::  |..|:...::.|  ::|||..::...|.||.|.:.|::.|....
Human   255 QVQLKQLQQRREEEMKNHQEILKAIQDVTIKRE--ETKKKIEKEKKEFLQKEQDLKAEIEKLCEK 317

  Fly   155 KEREVAAWKEKLDKLQ-RDGEHKIHALEATIAEFKTNC--------NYVPKVQPAEAPVQGHQQQ 210
            ..|||  |:.:||:|: :|||...:.:|.|...:|...        ..|.|::.||...:.|...
Human   318 GRREV--WEMELDRLKNQDGEINRNIMEETERAWKAEILSLESRKELLVLKLEEAEKEAELHLTY 380

  Fly   211 LNKPAEQMPTTHHSNPAQLAHS---IEKPRNEKSFDAQVQVSEGLYRIGGGVNLLATNPKQNL-- 270
            |......:.|.......:...:   |.|......|::.:|    |.|.|..::.|...|...|
Human   381 LKSTPPTLETVRSKQEWETRLNGVRIMKKNVRDQFNSHIQ----LVRNGAKLSSLPQIPTPTLPP 441

  Fly   271 TNASTNFTLKSNGDGTQEQPQL-PLQPFAVSN-NHSLILNSVE----NFQIVPKSVSEKQQQEEP 329
            ..:.|:|.|:.    .|..|.| |..||::.. ...:::.|.:    :|.|:..::|:..|
Human   442 PPSETDFMLQV----FQPSPSLAPRMPFSIGQVTMPMVMPSADPRSLSFPILNPALSQPSQ---- 498

  Fly   330 QLSGGPVSPLSAPRKSSTQASVGSASDKKAGDAPNASVAPK-----VSSSGLPPLAVPPAKTERK 389
                 |.|||......::.......|.......|.||:.|.     |.:|...|...|..|.|:.
Human   499 -----PSSPLPGSHGRNSPGLGSLVSPHGPHMPPAASIPPPPGLGGVKASAETPRPQPVDKLEKI 558

  Fly   390 LPENVAPIPE 399
            |.:.:...|:
Human   559 LEKLLTRFPQ 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12213	NP_001097754.1	CCDC158	<33..>213	CDD:292543	49/196 (25%)
RNF214	NP_001070707.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..197		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..552		16/74 (22%)
		zf-RING_2	654..699	CDD:290367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8005
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950