Protein Alignment aurA and C8orf44-SGK3

DIOPT Version :10

• Sequence 1: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001191102.1
• Gene: C8orf44-SGK3 / 100533105
• HGNCID: 48354
• Length: 496
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 113/453 - (24%)
• Similarity: 185/453 - (40%)
• Gaps: 91/453 - (20%)

  Fly     6 DHVLRPKENAP---------HRMPEKSAAVHNM--------------------QKNLLLGKKPNS 41
            ||.:..||:.|         ||..:|...|:.:                    ..|.|..:.|..
Human     4 DHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAM 68

  Fly    42 ENMAPASKPLPGSSGALIRKPGLGGSNSIASSEGNNFQKPMVPSVKKTTSEFAAPAPVAPIKKPE 106
            ....||.:..                       |:||....:...:...:||....    ::.||
Human    69 ALKIPAKRIF-----------------------GDNFDPDFIKQRRAGLNEFIQNL----VRYPE 106

  Fly   107 ---------SLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQ-----KPKKTWELNNFDIG 157
                     .|....|...|..|..|...:|.............|.     ||      .:||..
Human   107 LYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFL 165

  Fly   158 RLLGRGKFGNVYLAREKESQFVVALKVLFKR-QIGESNVEHQVRREIEIQSHLRHPHILRLYAYF 221
            :::|:|.||.|.||:.|......|:|||.|: .:.....:|.:.....:..:::||.::.|:..|
Human   166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSF 230

  Fly   222 HDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLL 286
            ....::|.:|::...|.||..||.:  :.|.|.::..|...:.|||.|||...|::||:||||:|
Human   231 QTTEKLYFVLDFVNGGELFFHLQRE--RSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENIL 293

  Fly   287 LGHKGVLKIADFGW-----SVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELL 346
            |...|.:.:.|||.     ::.:..:   |.|||.:||.||:::.:|:...||.|.||.:.:|:|
Human   294 LDSVGHVVLTDFGLCKEGIAISDTTT---TFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEML 355

  Fly   347 VGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLD----QVMVHPW 405
            .|..|||.::..|.|..||.....|...:|..|..::.:||..:.|:||...    ::..||:
Human   356 YGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	83/263 (32%)
C8orf44-SGK3	NP_001191102.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		5/16 (31%)
		PX_CISK	12..120	CDD:132780	18/134 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		6/34 (18%)
		STKc_SGK3	165..490	CDD:270755	81/259 (31%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)