Protein Alignment CG31211 and PNISR

DIOPT Version :10

• Sequence 1: NP_788641.1
• Gene: CG31211 / 41443
• FlyBaseID: FBgn0051211
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001309339.1
• Gene: PNISR / 25957
• HGNCID: 21222
• Length: 814
• Species: Homo sapiens
• Alignment Length: 886
• Identity: 232/886 - (26%)
• Similarity: 324/886 - (36%)
• Gaps: 271/886 - (30%)

  Fly    76 IDWAQLAQQWIHMRDATPVPMPLAPPPPIISNLREYHQQTLAMPVPSVVRAGFPQLEEHGEADMD 140
            ||||.|||.||..|:|:.....:..||.::.|.::.          |.:.:| |  ..||
Human    32 IDWAALAQAWIAQREASGQQSMVEQPPGMMPNGQDM----------STMESG-P--NNHG----- 78

  Fly   141 MDDENDRGHST------------ETPPPPAPLVTQSQWLAGTEVAGQIPDASNGAAVTLGKQPWT 193
                |.:|.|.            :.||.|.|   ...|:..|.....|...|..:
Human    79 ----NFQGDSNFNRMWQPEWGMHQQPPHPPP---DQPWMPPTPGPMDIVPPSEDS---------- 126

  Fly   194 GWQMQTDKSGN---STAHIPSLLKLNVSNPNEPHQQLQLQLQAHQQQQQQHAP---QPTHPHHPP 252
                .:..||.   ...||     .|.:|.|.........:....|...||..   .|....|||
Human   127 ----NSQDSGEFAPDNRHI-----FNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFHPP 182

  Fly   253 AHQPHAHPHHLTPHTHLPPQHTQQTHAESGSSGAS----------SEIDANKRKMLPAWIREGLE 307
            ..||.      .|....|||:.::..:.......|          .:|||.||:.||||||||||
Human   183 YWQPG------PPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLE 241

  Fly   308 KMEREKQRQLERQQSSMTTPDVEVNHVKQVSSKTLTTPGNLLNIANVASDSEDSIDVPVEARGEL 372
            |||||||::||:::.......:.....|............|...:...||.|:.....|||....
Human   242 KMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSG 306

  Fly   373 KVQQIGNELISKDDDRSSSSSEEPESELHGAIETGNRTVAEHVRMATVNDVNGKNYEERLADLML 437
            ||              :.|.|..|:.| |...|                    ...||:...:||
Human   307 KV--------------TRSPSPVPQEE-HSDPE--------------------MTEEEKEYQMML 336

  Fly   438 VVRRTLTEILLETTNEEIAAIAGETLKAHR--AKASSAQVIRKSALSSITGNLGLAAYGDSSSET 500
            :.:..||||||:.|:|||..:|.:   |||  .||.:.|:.:.|||:|:||..||..||..
Human   337 LTKMLLTEILLDVTDEEIYYVAKD---AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSG---- 394

  Fly   501 EDDEDDEDERQAGAGKDAEKSAQLSAEELKARIRRSKRSFEKVIDDIEDRVAKQELLDEQTLLRH 565
             |.||:..:|       ..:|:....|||:.|||:.:.:|.:          |::   ||.||..
Human   395 -DSEDERSDR-------GSESSDTDDEELRHRIRQKQEAFWR----------KEK---EQQLLHD 438

  Fly   566 RKRELERSVTGGGEHRRPAANPEPPSESASQATQEKHQQSNGIGDAHKSKELLSIHCHHLGKRLS 630
            ::.|.|:..|                   .:.|:|.::      ..||.:..||:        |.
Human   439 KQMEEEKQQT-------------------ERVTKEMNE------FIHKEQNSLSL--------LE 470

  Fly   631 RKERTTRFSDNKDGKQQSQSFVQQVVATAVVPPPGSLSNSSPQKLKPVPNPATNLLQMPESVATM 695
            .:|                             ..|.:.|..    |..||..|::|: |:
Human   471 ARE-----------------------------ADGDVVNEK----KRTPNETTSVLE-PK----- 496

  Fly   696 LTAADKALHKANKSSHKKSKRRHSSPSSSSSSSGSSSSSDSDDSSSTSSGSKTSGSR-SKRSSRH 759
                     |.:|...|:.:.|..|.||.||||.|.:||.|...||:|..|.:..|| |.|||..
Human   497 ---------KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP 552

  Fly   760 GHRSHHSSSRSK--YERRDRDR--------ERERARERERDRDRSHRQHRSSQLSGSHHQKQRRH 814
            ..:..||.|||.  ..||.|.|        |..|||.:.|||.||:|        .|..:::||:
Human   553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNR--------NSIERERRRN 609

  Fly   815 RESSHSGEDAGGSSSYHRSSRQSSSRSHDHG---------SNRSHDHGSSSSGRKRHRTRSRS-- 868
            |..|.....:...|...|::|.|.|||.|..         |..||.|...:..::|.:.||||
Human   610 RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSID 674

  Fly   869 -------KSRSTHHSSSK----------AYSSTSASHPRKR 892
                   |.|.......|          .:||......|||
Human   675 KDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31211	NP_788641.1	PNISR	290..493	CDD:464963	69/204 (34%)
PNISR	NP_001309339.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..331		77/330 (23%)
		PNISR	223..380	CDD:464963	63/194 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..805		116/448 (26%)