DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14731 and CG18088

DIOPT Version :9

Sequence 1:	NP_650130.1	Gene:	CG14731 / 41442	FlyBaseID:	FBgn0037964	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001260271.1	Gene:	CG18088 / 34219	FlyBaseID:	FBgn0032082	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	169/727 - (23%)
Similarity:	291/727 - (40%)	Gaps:	181/727 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FRLILMCIILYVLI------NFREQVEHKMKEQPP------IEGKPDNKMLFVNSSQCQINSMDP 67
            ::.:.:|..|.:::      |......|.:  .||      :..|.:.:..||.:|:|.|..:||
  Fly    12 YKFLALCCFLTIVLFLIYSSNTSSNTNHDL--YPPTTRFSRVSVKAEPQKFFVKTSKCHIPYVDP 74

  Fly    68 FSPTAMYHMTPMPSSACPMIKLMKPQSIDGMNYLYLIASAKELWKKLGVRRLSDIFCAYKRFVRF 132
            |:..||              :|.|||:        ||..:.|          :|:..     ..:
  Fly    75 FNDEAM--------------ELYKPQT--------LITCSNE----------TDLIS-----TTY 102

  Fly   133 NDFVN---IYFESTLFRFSKLRNFTKVDSGNITLRVWCW---MDYGRL----------------- 174
            |:.:.   ::.:..:.:  ||.|||..|..       |:   :.||::
  Fly   103 NEIIKRHILHIDDEVAQ--KLLNFTDKDYN-------CFYREIKYGKIADTYDNLKAKKYFTSGY 158

  Fly   175 ----------------------VYHDVFIFLPF-PNPQKVNNSAPVKRLSVLILGIDSISHMHYQ 216
                                  :..|.|.|:.. |.|:........::.||::.||||:|.::.:
  Fly   159 EVPVHVEGMIVECQTADDPIVVLQKDAFAFIQHRPLPKDSIRPRAARKPSVIMYGIDSLSRINLR 223

  Fly   217 RYFSRVRDLIEGLPHTELWGYNRVGQNSYPNLIPLLSGQSVDEVEA------KSGCYGASGGTNF 275
            |...:|.:.::|....|:.|||:|..||:||::.:|||.|....:.      |.||        .
  Fly   224 RTMPKVFNFLQGPGWYEMQGYNKVADNSFPNILAILSGYSASTAKENVCDTDKQGC--------L 280

  Fly   276 DRCHLLWHDFQAAGYATIFGEDSRVAGTFTYVRPGFKKRPTDFYLRSVINEIHMRSTYFARGPLE 340
            |...::|..|:.|.|.|.:.||...:..|.|::|||.|:|.|:|.|.::..:......:.....:
  Fly   281 DEMPMIWKYFKNASYLTGYAEDESNSNHFNYLKPGFSKKPMDYYFRPLLRALESEMDVYRLPEHD 345

  Fly   341 IK--CSGDRVYHHVLYDFIYRLLPHMQARMYDRGFFAFFWQTMGVHDYFQYGERADWEYYRIMRA 403
            ..  |.|.|:.:..:||:   .|...:..::||..:..||.....||            ...|.:
  Fly   346 YMRYCLGRRIANRYIYDY---GLQFTKRFVHDRPIWGMFWSNHFSHD------------DPFMPS 395

  Fly   404 LKRRKIL------------ERTLVLIVSDHGLRYGPFVDTFQGMRETSLPIMVAIYPRSLRERFP 456
            ..:.|:|            |..:::..:|||.|:|......:|..|..||:|....|...||.:|
  Fly   396 AMQEKVLGDLIDMHADGQFEEMIMIFFADHGTRFGDLTYLKEGFLEERLPMMFIYLPPWFRETYP 460

  Fly   457 LAFANLEANAHRLVTTYDLHETLKDVVDLENLSDERILNRTLRLRNNHNVSLFLPIPEERSCFSA 521
            .....||.|.|||.:.:|||.|||.::::....|.|.|.::.......  |||.|:||.|:|..|
  Fly   461 SYVRALELNQHRLSSNFDLHNTLKHIIEIGGTPDGRELPKSFDCPTCQ--SLFYPLPEGRTCSEA 523

  Fly   522 RIPLHYCQCDGYVKI---PWNVRSIQRIAKLAVANINRLLAPYPQ------CEQLELLNVEDAYL 577
            .|..|:|.|:.|..|   .|.       ..:|.:.|:|:...:.|      |..|.|..|....:
  Fly   524 GIEEHWCTCEPYKIISGQDWT-------TPIAHSVIDRMNEYFVQKNLTSLCSNLTLNYVHKTEI 581

  Fly   578 RKQHKL--NKTII--------VRLVTQPGNGHFDATVLSKNETSLQ----GPITRTDQYRHQSFC 628
            :....:  ::|::        ::...:..:..|.|||:..|.|...    ..|:||:.|:..|.|
  Fly   582 KTGLNIDWHQTLMESETAVYRIKFKVKQNSADFQATVVYHNSTQNAQVNVEKISRTNSYKEDSTC 646

  Fly   629 AREAPIEIYCYC 640
            ..:...::||.|
  Fly   647 IDDKLAKLYCIC 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14731	NP_650130.1	DUF229	77..573	CDD:281053	135/570 (24%)
CG14731	NP_650130.1	ALP_like	200..485	CDD:293745	86/304 (28%)
CG18088	NP_001260271.1	DUF229	84..577	CDD:281053	134/556 (24%)
CG18088	NP_001260271.1	ALP_like	207..489	CDD:293745	86/304 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31599at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850