DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14731 and T23E1.1

DIOPT Version :9

Sequence 1:	NP_650130.1	Gene:	CG14731 / 41442	FlyBaseID:	FBgn0037964	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001343691.1	Gene:	T23E1.1 / 188794	WormBaseID:	WBGene00020728	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	586	Identity:	127/586 - (21%)
Similarity:	202/586 - (34%)	Gaps:	154/586 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILMCIILYVLI-NFREQVEHKMKEQPPIEGKPDNKMLFVNS-SQCQ---INSMDPFSPTAMYHMT 77
            |:.||..::.| |:|  |....:|...:|  |.|...|.|. .|.:   .||..|:    |.|
Worm    13 IIFCIGFWIQISNYR--VRAHRREFESVE--PFNNFKFFNEIGQVEDENENSCYPY----MVH-- 67

  Fly    78 PMPSSACPMIKLMKPQSI-------------DGMNYLYLIASAKELWKKLGVRRLSDIFCAYKRF 129
               |....::.|:.|...             ||     ::..::.:::|....:..:..|.|...
Worm    68 ---SIEADILGLISPMIFSCNSPMGNWANFSDG-----ILTISERIFEKRKAEQNQNFTCVYAEI 124

  Fly   130 VRFNDFVNIYFESTLFRFSKLRN------FTKVDSGNITLRVWCWMDYGRLVYHDVFI-FLPFPN 187
            |...:..|   .:.|...|||..      .||::|....  |:|...:|...|:..|. ||  |.
Worm   125 VPKTELPN---GTILAEASKLETPIEPGIPTKIESEQFV--VFCRDPFGNHFYNKTFFNFL--PR 182

  Fly   188 PQKVNNSAPVKRLSVLILGIDSISHMHYQRYFSRVRDLIEGLPHTELWGYNRVGQNSYPNLIPLL 252
            .:.:.|.:.... |::||.|..:||....|:..|...............:|:..|::..|.:...
Worm   183 SETLTNLSSSDE-SLMILSISGMSHNQAMRHLKRSLKFAADNEFQSFSMFNQRSQDNLENSLKTF 246

  Fly   253 SG-QSVDEVEAKSGC----------YGASGGTNFDRCHLLWHDFQ-----------AAGYATIFG 295
            .| :.|..:...:||          :....|..||....|:..|.           :.|..|:
Worm   247 GGSEKVWNIAKNNGCPTFLNTDSPKFSKMYGYQFDYHSNLYSSFNKQYLGQVDNCISDGSVTV-- 309

  Fly   296 EDSRVAGTFTYVRPGFKKRPTDFYLRSVINEIHMRSTYFAR--GPLEIKCSG-DRVYHHVLYDFI 357
            ||:....             |:|.|....|..|....:|..  ||.:.|... |.|.::.|
Worm   310 EDAITLW-------------TNFSLTFHPNLCHFSLLHFTEVAGPGDGKIVNIDEVLNNSL---- 357

  Fly   358 YRLLPHMQARMYDRGFFAFFWQTMGVHDYFQYGERADWEYYRIMRALKRRKILERTLVLIVSDHG 422
             .:|                 |:.||                          |..|.|:|:||.|
Worm   358 -EIL-----------------QSFGV--------------------------LHNTTVVILSDGG 378

  Fly   423 LRYGPFVDTFQGMRETSLPIMVAIYPRSLRERFPLAFANLEANAHRLVTTYDLHETLKDVVDLEN 487
            .......:|..|..|:...:.:.....|.|:|||.....|:.|..||:|..|:.||||.::..:|
Worm   379 TGNSTIFETETGKLESRYGVFLIRLSDSYRKRFPENAEILKKNVDRLITNQDVAETLKHIIYDQN 443

  Fly   488 LSDERILNRTLRLRNNHNVSLFLPIPEERSCFSARIPLHYCQCD-----GYVKIPWNVRSIQRIA 547
            ..:....|..|...|:          :.|||..|.|...:|.|.     |..|.|..:|::.:|.
Worm   444 QENVTFENSLLSRENS----------KSRSCDIAGIEDEFCICSKLAQIGIDKRPEILRNLLKIV 498

  Fly   548 K 548
            |
Worm   499 K 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14731	NP_650130.1	DUF229	77..573	CDD:281053	108/522 (21%)
CG14731	NP_650130.1	ALP_like	200..485	CDD:293745	65/309 (21%)
T23E1.1	NP_001343691.1	DUF229	108..500	CDD:308570	103/473 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910