Protein Alignment CG14731 and T23E1.1

DIOPT Version :10

• Sequence 1: NP_650130.1
• Gene: CG14731 / 41442
• FlyBaseID: FBgn0037964
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001343691.1
• Gene: T23E1.1 / 188794
• WormBaseID: WBGene00020728
• Length: 603
• Species: Caenorhabditis elegans
• Alignment Length: 1745
• Identity: 316/1745 - (18%)
• Similarity: 542/1745 - (31%)
• Gaps: 683/1745 - (39%)

  Fly  1266 EVKLEGIKLGKEDQLRVVV--LPPANKAIPGANGGPPTEV-----------DTKVKKSSSKYEIS 1317
            |:.|||.   |....|.||  ..|...||.|.||...:.:           :.:..::::..|:.
 Worm     5 EICLEGF---KSYATRTVVPGFDPHFNAITGLNGSGKSNILDSICFVLGITNLQQVRAANLQELV 66

  Fly  1318 FKPTEVGTHKVFAYV--NDMQHPLSPFAVRVYDASEIIV---------------GEI--PNQ-SN 1362
            :|..:.|..:....|  ::.:...||....  |.|||.|               |::  ||| .|
 Worm    67 YKQGQAGITRATVSVTFDNSERNRSPLGHE--DHSEITVTRQIVVGGKNKYLINGKLAQPNQVQN 129

  Fly  1363 LNDTVEFTVDAGRAGFGNLEMAIKDADGVIIPSHVAQLESGSAKFLVTFTPATKGPHTVNITFNK 1427
            |                               .|..||...:..||:.....||
 Worm   130 L-------------------------------FHSVQLNVNNPHFLIMQGRITK----------- 152

  Fly  1428 EVLKNSPFEVNIVDAPLPAPVVLEPASGASAVASPSLSKKE--LKEQEKEKKREEKERAKREKEE 1490
             ||...|.|:         ..:||.|:|.....    :|||  ||..||::.:.::.....||:.
 Worm   153 -VLNMKPMEI---------LSMLEEAAGTRMYE----NKKEAALKTLEKKQTKVDEINKLLEKDI 203

  Fly  1491 RATLKKEKKSKSHRFPAKTTVSKIPSLSRVGQPSSLVVEVSGHDQLEIRVLDSKKSEIGTDIVEI 1555
            ...|:|.::.|                      |..:...:|:.:|: |:   |:..:..:.|:.
 Worm   204 LPALEKLRREK----------------------SQYMQWANGNAELD-RL---KRFCVAFEYVQA 242

  Fly  1556 EPGHMQINFTPAQVGDHEIDVRYGGVPVTGSPFTCRAYDPAKIKVGAIPKGLLDKPVYFTVDASE 1620
            |           ::.|:.|.|                .:..|||:..|.:         ..|.::
 Worm   243 E-----------KIRDNSIHV----------------VEEMKIKMTGIDE---------QTDKTQ 271

  Fly  1621 AGVGNLEVAVCEGRVPSMAHALGHHKYDISFVPKEDVDHTITVRFNNEPVPGSPFLCQLVATAQA 1685
            ..:..||.                                                 |:.|..||
 Worm   272 GEISELEK-------------------------------------------------QIKALTQA 287

  Fly  1686 TATGAGLERIPVDEETEIQILTDEIDSAPEARVRDPQGNDLPVNVTRSRENETLHIATYVPKCVG 1750
            .....|         .|::.|:|::||             |...|||.....|
 Worm   288 REASMG---------GEVKALSDKVDS-------------LSNEVTRELSKLT------------ 318

  Fly  1751 NHLIDIFLQGEPIAGSPFTAKAYDARKTVLVPPANAVVGKPATFVIDAARSGAGNMEIIVSVDNR 1815
             ::.|. ||||............|.:|:|                  ..|:.|.|     ..|
 Worm   319 -NMEDT-LQGEEKNAEKMVHNIEDLKKSV------------------EERASALN-----KCD-- 356

  Fly  1816 NVPNFVQAEGQARFKVSFTPQDAKDHTISVKFNGISVPGSPLICSVSSAGSVPAAVVLPAAAVIG 1880
                    ||.|..|..|............:..||       :...||.............|.|.
 Worm   357 --------EGAAELKQKFQEFSTTLEECEREHQGI-------LAGKSSGDEEKCLEDQLRDAKIS 406

  Fly  1881 AETAVAARERIKHTPQHSSEQIKQTTTTVLQKTPEIRETVEKTGLARELNSAQIGQKKGFTIDNI 1945
            ..||....:::.....|..:::|:..:.::.|..      |...:..||::     :|. .::::
 Worm   407 VGTAETELKQLNTKISHCEKELKEKKSQLMSKQD------EAVAVENELDA-----RKN-DVESV 459

  Fly  1946 NKSSDCNVIITAPDGSMVPVSIQKSSTSAYAEFTPTITGEHLVEIYLDHEIIDEFVIKIKDERHI 2010
            .::.|.   :...:|.|..:...:.|                 |:.:.|        ::||:.|.
 Worm   460 KRAFDS---LPYKEGQMEALEKDRES-----------------ELEIGH--------RLKDKVHE 496

  Fly  2011 LPPVCLAGQKYSF--DVNSDDKNKVRVTIREPSGRMLPVQMEDLPDGGVRVSCRFKEV--GIHSI 2071
            | ...||..::::  .|.:.|::||:..:.:      .:::.|      |.|....||  |....
 Worm   497 L-SAQLANVQFTYRDPVKNFDRSKVKGVVAK------LIKVND------RSSMTALEVTAGGKLF 548

  Fly  2072 DVFVDDQPIGERKMQ--------TVIDPLNGAQLVSEPKR---------------EIVGEQTELK 2113
            :|.||.:..|::.:|        |:| |||..|....|.|               .:||...|||
 Worm   549 NVIVDTEDTGKQLLQKGDLRRRVTII-PLNKIQSHLVPPRVQQATVGKGNAELALSLVGYSEELK 612

  Fly  2114 ILIDSGVESQVEVIIEGPDREDNEVFVKKVSETLWSAVWTPKVEGEHELSILVAGEQIPGSPFPI 2178
                    :.:|.:.       ...||.|.::......:..::...   |:.:.|:
 Worm   613 --------NAMEYVF-------GSTFVCKTTDAAKEVAFNREIRTP---SVTLEGD--------- 650

  Fly  2179 HVLDPSAVRVIGLKNAPVGVEQQF------SVDYTNSGASIASVEVRHGDQTIPITVKKMKPGQL 2237
             |..||.:...|.:.....:.:|.      ...:.....|::.:|.         .:|:::|.|
 Worm   651 -VFQPSGLLTGGSRKGGGDLLRQLHDLAEAETKFRAHQKSLSEIEA---------NIKELQPLQ- 704

  Fly  2238 LCTFTPFVDGPHQVEVIIDGVPLSDGPYEVFISHLGTVRAS-------GDALRKAQRARTARFEV 2295
                |.|.|...|:|:            :::...|...||.       |||::|.:.
 Worm   705 ----TKFTDMKAQLEL------------KMYDMSLFLKRAEQNEHHKLGDAVKKLEE-------- 745

  Fly  2296 INVEQNRGELDVMVSDPKGGPLPVRCYKQQDDSYWVEFTPEHLGTHTIEVTFGDVPVPGSPFKTE 2360
             .||:.|.:    :.:.:|      .||...|:           ..|:|.:..|
 Worm   746 -EVEEMRSQ----IKEKEG------LYKSCADT-----------VSTLEKSIKD----------- 777

  Fly  2361 VIDPKNVEIRGLSDQVLLRHATTINVDRRNAGNGELQVEITDPTGSPLRTEMLKSPGGEDRITFL 2425
              ..||.|.| |.|  |.::..|:        ...:|....|..|
 Worm   778 --HDKNREGR-LKD--LEKNIKTL--------KARIQASSKDLKG-------------------- 809

  Fly  2426 PNQTGPHKINVKVAGFQIPGYPQTILVSEQEKPAVYGAAVDQSIKIGEPASLIFDPKKTNGGLKI 2490
                  |: ||:..           ||.|||     ....:||....:..||     :|.  :..
 Worm   810 ------HE-NVRER-----------LVMEQE-----AVTQEQSYLKSQLTSL-----RTQ--IST 844

  Fly  2491 HATGPDGQKVHHNVMRRPNGTSEVVFYPEETGTYNVSIDFNNRPITGSPFTVNVVDPTKVI--VN 2553
            .|:....|:...:.:::.:..|     ..|....:..:...:..|:||     :.:..|.:  ::
 Worm   845 LASDVGNQRAKVDAIQKDHDQS-----LSELKLIHAKMKECDTQISGS-----IAEQEKCLQKIS 899

  Fly  2554 DLDMDR----DGTLLLRLGHSN-SFDVDATAAGPGKLRAEVRDADSSLIGNGPVVEDMGQGKYRV 2613
            |:.:||    :....:.:.|.| |..||........:.:|.|     |.|||....|.
 Worm   900 DMKLDRKKLENEVTRMEMEHKNCSVKVDKLVEKHTWITSEKR-----LFGNGGTDYDF------- 952

  Fly  2614 RFNPDQPGKYSIYLYWNELPVESAFPVRARSSAEDLPTTSRAVREPIPPPVTTTYHTREKSSGSN 2678
                                 ||..|.:||...|.|.|...::.:.:...||..:   ||
 Worm   953 ---------------------ESRDPHKAREELERLQTDQSSLEKRVNKKVTAMF---EK----- 988

  Fly  2679 ADDEISRIMVRGDGLH------RAVLKEHNE-----FIIDGSDINKE-GRITATLLGSKADIPVR 2731
            |:||.:.:|.:.:.:.      :.|::|.:|     ..:....:|:: |.|.:|||      |..
 Worm   989 AEDEYNALMTKKNIIETDKSKIKKVIEELDEKKKETLKVTWVKVNQDFGSIFSTLL------PGT 1047

  Fly  2732 IQQLGHNVYKATYTPLTGGTYELHILWNGKHVK---GSPFAVSADTSAHLADLIDVDASTLKIGI 2793
            :.:|         .|..|||:     .:|..|:   |..:..|      |::|.....|.|.:.:
 Worm  1048 MSKL---------EPPEGGTF-----LDGLEVRVAFGDVWKQS------LSELSGGQRSLLALSL 1092

  Fly  2794 INENIKTLIDTRRAGSGQLSALCMGPNKPAYCELYDHRDGTYALCVRPAEIGKHTLVIKYDDEHV 2858
            |                 |:.|..   |||...:.|..|....|. ....||:   :||   .|.
 Worm  1093 I-----------------LALLLF---KPAPIYILDEVDAALDLS-HTQNIGR---MIK---SHF 1130

  Fly  2859 KGSPFVVHVSLPPDPSKVRVYGPGVEHGILS----LFKSNFVVETRGAGAGQLTV 2909
            ..|.|:| |||              :.|:.|    ||::.||   .|....|.||
 Worm  1131 PHSQFIV-VSL--------------KEGMFSNADVLFRTKFV---DGVSTVQRTV 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14731	NP_650130.1	DUF229	77..573	CDD:397236
T23E1.1	NP_001343691.1	DUF229	108..500	CDD:397236	107/675 (16%)