DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14731 and T07G12.3

DIOPT Version :9

Sequence 1:	NP_650130.1	Gene:	CG14731 / 41442	FlyBaseID:	FBgn0037964	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_501945.2	Gene:	T07G12.3 / 188242	WormBaseID:	WBGene00011594	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	167/685 - (24%)
Similarity:	260/685 - (37%)	Gaps:	198/685 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KPDNKMLFVNSSQCQINSMDPFSPTAMYHMTPMPSSACPMIKLMKPQSIDGMNYLYLIASAKELW 111
            |.::|.|:::||:...|                 ..|.|:             |.|...|.|.:.
Worm    31 KIESKFLYLDSSRSAHN-----------------ICALPI-------------YDYWDTSIKNVM 65

  Fly   112 KKLGVRRLSDIFCAYKRFVRFNDFVNIYFESTLFRFSK------LRNFTKV-DSGNITLRVW--- 166
            .:....|     ..||.:|::.:.||     :.:|..|      .|.|:.: .|.|:.:..|
Worm    66 HEYNPAR-----NCYKNYVQWTELVN-----STWRIVKDGANCLARCFSGIGGSKNVKIGPWMKP 120

  Fly   167 -----------CWMD----YGRLVYHDVFIFLPFPNPQKVN----NSAPVKRLSVLILGIDSISH 212
                       ||.|    ||.:  |...|      |:|.:    ..||    :|.|..||:::.
Worm   121 GHVDCEFLETVCWEDNIEVYGHI--HTQII------PRKASPTKFKDAP----NVFIFTIDAMNT 173

  Fly   213 MHYQR-------YFSRVRDLIEGLPHTELWGYNRVGQNSYPNLIPLLSGQSV--------DEVEA 262
            ...:|       ||.....:|| .|..     |:||:||.||.:||..|:|:        |:||.
Worm   174 GMAKRSFPKLLSYFKNEFQMIE-FPFV-----NKVGENSRPNGLPLWFGKSIEGGRRVTGDDVEV 232

  Fly   263 ----KSGCYGASGGTNFDRCHLLWHDFQAAGYATIFGED--SRVAGTF-TYVRPGFKKRPTDFYL 320
                ...|     .|..|....::.||:..||||:..||  ..|..:: |.|  ||::.|||...
Worm   233 DWDWNQYC-----ETYLDNSSHIFKDFKDHGYATMLFEDWEGNVVDSWPTCV--GFEEPPTDHTF 290

  Fly   321 R--SVINEIHMRSTYFARGPLEI---KCSGD--RVYHHVLYDFIYRLLPHMQARMYDRGFFAFFW 378
            |  :.::|.|         .:||   ..||.  |..||.    |..||........||..|::.|
Worm   291 RPFASVSETH---------GMEITKRHLSGKFCRETHHA----IMELLEQGIEAYKDRPIFSWLW 342

  Fly   379 QTMGVHDYFQYGERADWEYYRIMRALKRRKILERTLVLIVSDHGLRYGPFVDTFQGMRETSLPIM 443
            .....||:.....|.|  .|.:....|...:.:.:.|:.|||||||.|..:.|..|..|...|.:
Worm   343 LAWVAHDWIDGAARVD--EYLVNYFKKHNNMFDNSFVMFVSDHGLRTGKHMRTEIGAFERDNPFL 405

  Fly   444 VAIYPRSLR-ERFPLAFANLEANAHRLVTTYDLHETLKDVVDLE-----------NLSDERILNR 496
            ....|:..| .:|.: ...|..::.:|.|.:|:..||.|::..:           |:.||:
Worm   406 SISIPKRFRATKFGI-LETLNFDSKQLQTHFDVRATLLDILKFQPTSKFMDRQQKNIPDEK---- 465

  Fly   497 TLRLRNNHNVSLFLPIPE-ERSCFSARIPLHYCQC--DGY------VKIPWNVRSIQRI-AKLAV 551
                  .|  ||....|: .|:|.:..||..:|.|  |.:      :|.....:.:..: .||..
Worm   466 ------GH--SLIRKQPDFPRTCATLPIPQQWCICQVDKFEIHNETLKNHLGEKLLNHVHRKLKK 522

  Fly   552 ANINRLLAPYPQCEQLELLNV----EDAYLR--KQHKLNKTIIVRLVTQPGNGHFDATVLSKNET 610
            .|::.:      ||...|..|    |..|:|  :.:|::..     .|.....||:..|....||
Worm   523 LNVSEI------CETFRLSKVTSLIEYGYVRTMRTYKISVE-----TTISSYAHFETFVTYDIET 576

  Fly   611 SLQ--GPITRTDQYRHQSFCA---REAPIEIYCYC 640
            .:.  ..:||.|.|...:.|.   |::|:   |||
Worm   577 DIAKFEKVTRLDNYAMTTDCTKPIRQSPL---CYC 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14731	NP_650130.1	DUF229	77..573	CDD:281053	141/579 (24%)
CG14731	NP_650130.1	ALP_like	200..485	CDD:293745	89/314 (28%)
T07G12.3	NP_501945.2	DUF229	67..538	CDD:281053	134/539 (25%)
T07G12.3	NP_501945.2	ALP_like	161..448	CDD:293745	90/319 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.980